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- W2595526360 abstract "Research of the opioid system and its composite receptors and ligands has revealed its promise as a potential therapy for neurodegenerative diseases such as stroke and Parkinson's Disease. In particular, delta opioid receptors (DORs) have been elucidated as a therapeutically distinguished subset of opioid receptors and a compelling target for novel intervention techniques. Research is progressively shedding light on the underlying mechanism of DORs and has revealed two mechanisms of DOR neuroprotection; DORs function to maintain ionic homeostasis and also to trigger endogenous neuroprotective pathways. Delta opioid agonists such as (D-Ala2, D-Leu5) enkephalin (DADLE) have been shown to promote neuronal survival and decrease apoptosis, resulting in a substantial amount of research for its application as a neurological therapeutic. Most notably, DADLE has demonstrated significant potential to reduce cell death following ischemic events. Current research is working to reveal the complex mechanisms of DADLE's neuroprotective properties. Ultimately, our knowledge of the DOR receptors and agonists has made the opioid system a promising target for therapeutic intervention in many neurological disorders." @default.
- W2595526360 created "2017-03-23" @default.
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- W2595526360 date "2017-01-01" @default.
- W2595526360 modified "2023-10-06" @default.
- W2595526360 title "Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders" @default.
- W2595526360 cites W1483108783 @default.
- W2595526360 cites W1508857702 @default.
- W2595526360 cites W1516736832 @default.
- W2595526360 cites W1521003613 @default.
- W2595526360 cites W1549338235 @default.
- W2595526360 cites W1631527540 @default.
- W2595526360 cites W1827049966 @default.
- W2595526360 cites W1893839706 @default.
- W2595526360 cites W1954347758 @default.
- W2595526360 cites W1964158979 @default.
- W2595526360 cites W1965394539 @default.
- W2595526360 cites W1966183236 @default.
- W2595526360 cites W1968283159 @default.
- W2595526360 cites W1970628154 @default.
- W2595526360 cites W1972503578 @default.
- W2595526360 cites W1972968801 @default.
- W2595526360 cites W1982117704 @default.
- W2595526360 cites W1984934908 @default.
- W2595526360 cites W1988951836 @default.
- W2595526360 cites W1989687092 @default.
- W2595526360 cites W1992672476 @default.
- W2595526360 cites W1997398295 @default.
- W2595526360 cites W2003382287 @default.
- W2595526360 cites W2005509576 @default.
- W2595526360 cites W2008899742 @default.
- W2595526360 cites W2013543516 @default.
- W2595526360 cites W2016138343 @default.
- W2595526360 cites W2019607920 @default.
- W2595526360 cites W2020333978 @default.
- W2595526360 cites W2021704800 @default.
- W2595526360 cites W2021737943 @default.
- W2595526360 cites W2023851153 @default.
- W2595526360 cites W2026412461 @default.
- W2595526360 cites W2027829677 @default.
- W2595526360 cites W2027946127 @default.
- W2595526360 cites W2029910984 @default.
- W2595526360 cites W2039183571 @default.
- W2595526360 cites W2040440615 @default.
- W2595526360 cites W2040911324 @default.
- W2595526360 cites W2045639123 @default.
- W2595526360 cites W2051490174 @default.
- W2595526360 cites W2052246500 @default.
- W2595526360 cites W2053073047 @default.
- W2595526360 cites W2054987524 @default.
- W2595526360 cites W2055082208 @default.
- W2595526360 cites W2055988887 @default.
- W2595526360 cites W2056494317 @default.
- W2595526360 cites W2058342631 @default.
- W2595526360 cites W2060255428 @default.
- W2595526360 cites W2060389245 @default.
- W2595526360 cites W2061134295 @default.
- W2595526360 cites W2061469109 @default.
- W2595526360 cites W2064300184 @default.
- W2595526360 cites W2068739576 @default.
- W2595526360 cites W2071742508 @default.
- W2595526360 cites W2072955770 @default.
- W2595526360 cites W2076052474 @default.
- W2595526360 cites W2076101724 @default.
- W2595526360 cites W2076493123 @default.
- W2595526360 cites W2079439105 @default.
- W2595526360 cites W2081466847 @default.
- W2595526360 cites W2081894019 @default.
- W2595526360 cites W2082420976 @default.
- W2595526360 cites W2082490296 @default.
- W2595526360 cites W2083114813 @default.
- W2595526360 cites W2083136363 @default.
- W2595526360 cites W2084888009 @default.
- W2595526360 cites W2087362900 @default.
- W2595526360 cites W2088738768 @default.
- W2595526360 cites W2089696270 @default.
- W2595526360 cites W2090276138 @default.
- W2595526360 cites W2093309825 @default.
- W2595526360 cites W2102696048 @default.
- W2595526360 cites W2106628227 @default.
- W2595526360 cites W2111171996 @default.
- W2595526360 cites W2119922145 @default.
- W2595526360 cites W2131946963 @default.
- W2595526360 cites W2145645917 @default.
- W2595526360 cites W2147243399 @default.
- W2595526360 cites W2149522871 @default.
- W2595526360 cites W2153276387 @default.
- W2595526360 cites W2154390677 @default.
- W2595526360 cites W2156488055 @default.
- W2595526360 cites W2160038308 @default.
- W2595526360 cites W2162813640 @default.
- W2595526360 cites W2311955063 @default.
- W2595526360 cites W2334628654 @default.
- W2595526360 cites W2367812079 @default.