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- W2595581354 endingPage "11" @default.
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- W2595581354 abstract "Worms have co-evolved with humans over millions of years. To survive, they manipulate host systems by modulating immune responses so that they cause (in the majority of hosts) relatively subtle harm. Anthelminthic treatment has been promoted as a measure for averting worm specific pathology and to mitigate subtle morbidities which may include effects on anaemia, growth, cognitive function and economic activity. With our changing environment marked by rapid population growth, urbanisation, better hygiene practices and anthelminthic treatment, there has been a decline in worm infections and other infectious diseases and a rise in non-communicable diseases such as allergy, diabetes and cardiovascular disease. This review reflects upon our age-old interaction with worms, and the broader ramifications of life without worms for vaccine responses and susceptibility to other infections, and for allergy-related and metabolic disease. We touch upon the controversy around the benefits of mass drug administration for the more-subtle morbidities that have been associated with worm infections and then focus our attention on broader, additional aspects of life without worms, which may be either beneficial or detrimental." @default.
- W2595581354 created "2017-03-23" @default.
- W2595581354 creator A5017313491 @default.
- W2595581354 creator A5028523609 @default.
- W2595581354 creator A5033090746 @default.
- W2595581354 creator A5047582817 @default.
- W2595581354 creator A5075679477 @default.
- W2595581354 date "2017-01-01" @default.
- W2595581354 modified "2023-09-27" @default.
- W2595581354 title "A life without worms" @default.
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