Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595584585> ?p ?o ?g. }
- W2595584585 abstract "Significance Post-traumatic sterile inflammation is the first necessary step of wound healing. In addition, sterile inflammation underlies the pathogenesis of a multitude of common diseases, such as allergies and autoimmune diseases. The molecular mechanisms underlying sterile inflammation are still not fully understood. Here, we show that the receptor Mincle (Clec4e), the expression of which is highly induced in the skin in response to damage, recognizes cholesterol sulfate, a molecule that is abundant in the epidermal layer of the skin, subsequently inducing a pro-inflammatory response. We also identify a role for Mincle as a driving component in the pathogenesis of allergic skin inflammation. The results demonstrate a previously unconsidered important role of Mincle in mediating sterile inflammation." @default.
- W2595584585 created "2017-03-23" @default.
- W2595584585 creator A5001013377 @default.
- W2595584585 creator A5002983121 @default.
- W2595584585 creator A5005826194 @default.
- W2595584585 creator A5006403221 @default.
- W2595584585 creator A5009981810 @default.
- W2595584585 creator A5013692816 @default.
- W2595584585 creator A5020728152 @default.
- W2595584585 creator A5027867374 @default.
- W2595584585 creator A5034856930 @default.
- W2595584585 creator A5035008126 @default.
- W2595584585 creator A5036628717 @default.
- W2595584585 creator A5046395158 @default.
- W2595584585 creator A5056056811 @default.
- W2595584585 creator A5060510338 @default.
- W2595584585 creator A5061808420 @default.
- W2595584585 creator A5068710750 @default.
- W2595584585 creator A5070967582 @default.
- W2595584585 creator A5073677681 @default.
- W2595584585 creator A5078851169 @default.
- W2595584585 creator A5084556413 @default.
- W2595584585 creator A5085732220 @default.
- W2595584585 date "2017-03-14" @default.
- W2595584585 modified "2023-10-14" @default.
- W2595584585 title "Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate" @default.
- W2595584585 cites W1169101687 @default.
- W2595584585 cites W1498111709 @default.
- W2595584585 cites W1615432648 @default.
- W2595584585 cites W1735091417 @default.
- W2595584585 cites W1758479260 @default.
- W2595584585 cites W1768230857 @default.
- W2595584585 cites W1812613913 @default.
- W2595584585 cites W1932984089 @default.
- W2595584585 cites W1965536984 @default.
- W2595584585 cites W1968052811 @default.
- W2595584585 cites W1972483153 @default.
- W2595584585 cites W1979688234 @default.
- W2595584585 cites W1994190235 @default.
- W2595584585 cites W1998511061 @default.
- W2595584585 cites W2005183346 @default.
- W2595584585 cites W2012706589 @default.
- W2595584585 cites W2024272840 @default.
- W2595584585 cites W2029827552 @default.
- W2595584585 cites W2031558559 @default.
- W2595584585 cites W2033883349 @default.
- W2595584585 cites W2035096151 @default.
- W2595584585 cites W2041064429 @default.
- W2595584585 cites W2041971745 @default.
- W2595584585 cites W2042851093 @default.
- W2595584585 cites W2065429310 @default.
- W2595584585 cites W2074296560 @default.
- W2595584585 cites W2085137882 @default.
- W2595584585 cites W2093041047 @default.
- W2595584585 cites W2114737175 @default.
- W2595584585 cites W2116767253 @default.
- W2595584585 cites W2125651775 @default.
- W2595584585 cites W2132822330 @default.
- W2595584585 cites W2135354472 @default.
- W2595584585 cites W2135817296 @default.
- W2595584585 cites W2138258126 @default.
- W2595584585 cites W2145168389 @default.
- W2595584585 cites W2145736817 @default.
- W2595584585 cites W2150594596 @default.
- W2595584585 cites W2158500407 @default.
- W2595584585 cites W2159421887 @default.
- W2595584585 cites W2166676682 @default.
- W2595584585 cites W2239399748 @default.
- W2595584585 cites W2287887328 @default.
- W2595584585 cites W2299393419 @default.
- W2595584585 cites W2303771534 @default.
- W2595584585 cites W2324467793 @default.
- W2595584585 cites W2327515900 @default.
- W2595584585 cites W2423259930 @default.
- W2595584585 cites W4251713028 @default.
- W2595584585 cites W48578805 @default.
- W2595584585 cites W965872770 @default.
- W2595584585 doi "https://doi.org/10.1073/pnas.1611665114" @default.
- W2595584585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5380039" @default.
- W2595584585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28292894" @default.
- W2595584585 hasPublicationYear "2017" @default.
- W2595584585 type Work @default.
- W2595584585 sameAs 2595584585 @default.
- W2595584585 citedByCount "61" @default.
- W2595584585 countsByYear W25955845852017 @default.
- W2595584585 countsByYear W25955845852018 @default.
- W2595584585 countsByYear W25955845852019 @default.
- W2595584585 countsByYear W25955845852020 @default.
- W2595584585 countsByYear W25955845852021 @default.
- W2595584585 countsByYear W25955845852022 @default.
- W2595584585 countsByYear W25955845852023 @default.
- W2595584585 crossrefType "journal-article" @default.
- W2595584585 hasAuthorship W2595584585A5001013377 @default.
- W2595584585 hasAuthorship W2595584585A5002983121 @default.
- W2595584585 hasAuthorship W2595584585A5005826194 @default.
- W2595584585 hasAuthorship W2595584585A5006403221 @default.
- W2595584585 hasAuthorship W2595584585A5009981810 @default.
- W2595584585 hasAuthorship W2595584585A5013692816 @default.
- W2595584585 hasAuthorship W2595584585A5020728152 @default.
- W2595584585 hasAuthorship W2595584585A5027867374 @default.