Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595683637> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2595683637 endingPage "432" @default.
- W2595683637 startingPage "432" @default.
- W2595683637 abstract "During pregnancy and lactation, corticosterone secretory responses of adrenal gland are attenuated in the rats, and this has been explained by reduced responsiveness of corticotropin-releasing hormone and vasopressin neurons in the parvocellular paraventricular nucleus. To further clarify the hyporesponsiveness of the hypothalamo-pituitary-adrenal axis in pregnancy and lactation, the secretory ability of adrenocortical cell for corticosterone and progesterone in response to adrenocorticotropin (ACTH) were compared among cyclic, pregnant day (PD5, 10, 15 and 20) and lactating (LD5 and 15) rats using the primary adrenal cell culture system. The absolute weight of adrenal gland was not different among cyclic, pregnant and lactating rats. The basal secretion of corticosterone in culture adrenal cells was significantly high in PD10, but low in PD20, whereas the basal secretion of progesterone was significantly high in PD 20 as compared with cyclic rats. During lactation period, however, the basal progesterone was significantly high in LD5 than LD 15. Administration of ACTH (10-15 to 10-10M) resulted in a clear dose-dependent increase in corticosterone and progesterone secretion in cyclic rats. On the other hand, no responses of ACTH stimulation was observed in corticosterone and progesterone secretion by cultured adrenal cells from pregnant rats (PD5 to 20) and early lactating rats (LD5). Both the secretion of corticosterone and progesterone from adrenocortical cells in response to ACTH started to recover from LD15, while sensitivity was lower in progesterone compared with corticosterone. These results clearly demonstrated that adrenocortical cells showed a dramatic change in secretion of corticosterone and progesterone during pregnancy and lactation in the rats. These results also demonstrated at the first time that not only the hypothalamus and pituitary gland, but also corticosterone and progesterone secretion is reduced from adrenocortical cells of pregnant and early lactating rats, indicating an important mechanism responsible for minimizing excess amounts of glucocorticoid exposure to fetus and neonates in the peripartum period. (poster)" @default.
- W2595683637 created "2017-03-23" @default.
- W2595683637 creator A5022881238 @default.
- W2595683637 creator A5047684890 @default.
- W2595683637 creator A5054159681 @default.
- W2595683637 creator A5068663785 @default.
- W2595683637 date "2010-11-01" @default.
- W2595683637 modified "2023-09-23" @default.
- W2595683637 title "Dynamic Changes in Secretory Activity of Adrenocortical Cell During the Reproductive Cycle in Female Rats." @default.
- W2595683637 doi "https://doi.org/10.1093/biolreprod/83.s1.432" @default.
- W2595683637 hasPublicationYear "2010" @default.
- W2595683637 type Work @default.
- W2595683637 sameAs 2595683637 @default.
- W2595683637 citedByCount "0" @default.
- W2595683637 crossrefType "journal-article" @default.
- W2595683637 hasAuthorship W2595683637A5022881238 @default.
- W2595683637 hasAuthorship W2595683637A5047684890 @default.
- W2595683637 hasAuthorship W2595683637A5054159681 @default.
- W2595683637 hasAuthorship W2595683637A5068663785 @default.
- W2595683637 hasConcept C126322002 @default.
- W2595683637 hasConcept C134018914 @default.
- W2595683637 hasConcept C2776370428 @default.
- W2595683637 hasConcept C2776659692 @default.
- W2595683637 hasConcept C2778024521 @default.
- W2595683637 hasConcept C2779234561 @default.
- W2595683637 hasConcept C2779306644 @default.
- W2595683637 hasConcept C2780352252 @default.
- W2595683637 hasConcept C2780546910 @default.
- W2595683637 hasConcept C2780694816 @default.
- W2595683637 hasConcept C49039625 @default.
- W2595683637 hasConcept C54355233 @default.
- W2595683637 hasConcept C71315377 @default.
- W2595683637 hasConcept C71924100 @default.
- W2595683637 hasConcept C86803240 @default.
- W2595683637 hasConceptScore W2595683637C126322002 @default.
- W2595683637 hasConceptScore W2595683637C134018914 @default.
- W2595683637 hasConceptScore W2595683637C2776370428 @default.
- W2595683637 hasConceptScore W2595683637C2776659692 @default.
- W2595683637 hasConceptScore W2595683637C2778024521 @default.
- W2595683637 hasConceptScore W2595683637C2779234561 @default.
- W2595683637 hasConceptScore W2595683637C2779306644 @default.
- W2595683637 hasConceptScore W2595683637C2780352252 @default.
- W2595683637 hasConceptScore W2595683637C2780546910 @default.
- W2595683637 hasConceptScore W2595683637C2780694816 @default.
- W2595683637 hasConceptScore W2595683637C49039625 @default.
- W2595683637 hasConceptScore W2595683637C54355233 @default.
- W2595683637 hasConceptScore W2595683637C71315377 @default.
- W2595683637 hasConceptScore W2595683637C71924100 @default.
- W2595683637 hasConceptScore W2595683637C86803240 @default.
- W2595683637 hasIssue "Suppl_1" @default.
- W2595683637 hasLocation W25956836371 @default.
- W2595683637 hasOpenAccess W2595683637 @default.
- W2595683637 hasPrimaryLocation W25956836371 @default.
- W2595683637 hasRelatedWork W1591295047 @default.
- W2595683637 hasRelatedWork W1964318160 @default.
- W2595683637 hasRelatedWork W1966654712 @default.
- W2595683637 hasRelatedWork W2032245308 @default.
- W2595683637 hasRelatedWork W2035704182 @default.
- W2595683637 hasRelatedWork W2062252989 @default.
- W2595683637 hasRelatedWork W2078632969 @default.
- W2595683637 hasRelatedWork W2085366988 @default.
- W2595683637 hasRelatedWork W2104452243 @default.
- W2595683637 hasRelatedWork W4247950900 @default.
- W2595683637 hasVolume "83" @default.
- W2595683637 isParatext "false" @default.
- W2595683637 isRetracted "false" @default.
- W2595683637 magId "2595683637" @default.
- W2595683637 workType "article" @default.