FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595688691> ?p ?o ?g. }

• W2595688691 endingPage "20" @default.
• W2595688691 startingPage "16" @default.
• W2595688691 abstract "Abstract Many hold that the so‐called golden era of antibiotic discovery has passed, leaving only a limited clinical pipeline for new antibiotics. A logical conclusion of such arguments is that we need to reform the current system of antibiotic drug research—including clinical trials and regulatory requirements—to spur activity in discovery and development. The United States Congress in the past few years has debated a number of bills to address this crisis, including the 2012 Generating Antibiotic Incentives Now Act and the 2016 21st Century Cures Act. Experts have also sought to advance antibiotic development by encouraging greater use of trials with noninferiority hypotheses, which are thought to be easier to conduct. The goal underlying these proposals is to stave off the post‐antibiotic era by expanding the pharmaceutical armamentarium as quickly as possible. But although new antibiotic agents are necessary to combat the long‐term threat of drug‐resistant disease, we argue that these research policies, which effectively lower the bar for antibiotic approval, are ethically problematic. Rather, given broader public health considerations related to the full lifecycle of antibiotic use—including development of resistance—we should reject an overly permissive approach to new antibiotic approval and instead set the bar for regulatory approval at a point that will naturally direct research resources toward the most transformative chemical or social interventions." @default.
• W2595688691 created "2017-03-23" @default.
• W2595688691 creator A5008017533 @default.
• W2595688691 creator A5074257304 @default.
• W2595688691 date "2017-03-01" @default.
• W2595688691 modified "2023-09-23" @default.
• W2595688691 title "Reprioritizing Research Activity for the Post‐Antibiotic Era: <i>Ethical, Legal, and Social Considerations</i>" @default.
• W2595688691 cites W1964628019 @default.
• W2595688691 cites W1969818546 @default.
• W2595688691 cites W1971491551 @default.
• W2595688691 cites W1997362383 @default.
• W2595688691 cites W2007331931 @default.
• W2595688691 cites W2009696117 @default.
• W2595688691 cites W2021702829 @default.
• W2595688691 cites W2040094585 @default.
• W2595688691 cites W2044591801 @default.
• W2595688691 cites W2045701919 @default.
• W2595688691 cites W2048703052 @default.
• W2595688691 cites W2056830352 @default.
• W2595688691 cites W2074593787 @default.
• W2595688691 cites W2081747790 @default.
• W2595688691 cites W2086509129 @default.
• W2595688691 cites W2101571099 @default.
• W2595688691 cites W2105703901 @default.
• W2595688691 cites W2109028417 @default.
• W2595688691 cites W2115196817 @default.
• W2595688691 cites W2115486016 @default.
• W2595688691 cites W2127689004 @default.
• W2595688691 cites W2134529369 @default.
• W2595688691 cites W2135497046 @default.
• W2595688691 cites W2137766299 @default.
• W2595688691 cites W2138939303 @default.
• W2595688691 cites W2140353364 @default.
• W2595688691 cites W2256121991 @default.
• W2595688691 cites W2418190818 @default.
• W2595688691 cites W3124144403 @default.
• W2595688691 cites W4253898901 @default.
• W2595688691 doi "https://doi.org/10.1002/hast.685" @default.
• W2595688691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28301705" @default.
• W2595688691 hasPublicationYear "2017" @default.
• W2595688691 type Work @default.
• W2595688691 sameAs 2595688691 @default.
• W2595688691 citedByCount "7" @default.
• W2595688691 countsByYear W25956886912017 @default.
• W2595688691 countsByYear W25956886912018 @default.
• W2595688691 countsByYear W25956886912019 @default.
• W2595688691 countsByYear W25956886912021 @default.
• W2595688691 countsByYear W25956886912022 @default.
• W2595688691 crossrefType "journal-article" @default.
• W2595688691 hasAuthorship W2595688691A5008017533 @default.
• W2595688691 hasAuthorship W2595688691A5074257304 @default.
• W2595688691 hasConcept C142724271 @default.
• W2595688691 hasConcept C144024400 @default.
• W2595688691 hasConcept C162324750 @default.
• W2595688691 hasConcept C175444787 @default.
• W2595688691 hasConcept C17744445 @default.
• W2595688691 hasConcept C190253527 @default.
• W2595688691 hasConcept C2780035454 @default.
• W2595688691 hasConcept C29122968 @default.
• W2595688691 hasConcept C39549134 @default.
• W2595688691 hasConcept C501593827 @default.
• W2595688691 hasConcept C535046627 @default.
• W2595688691 hasConcept C64903051 @default.
• W2595688691 hasConcept C71924100 @default.
• W2595688691 hasConcept C86803240 @default.
• W2595688691 hasConcept C89423630 @default.
• W2595688691 hasConcept C94665300 @default.
• W2595688691 hasConcept C98274493 @default.
• W2595688691 hasConceptScore W2595688691C142724271 @default.
• W2595688691 hasConceptScore W2595688691C144024400 @default.
• W2595688691 hasConceptScore W2595688691C162324750 @default.
• W2595688691 hasConceptScore W2595688691C175444787 @default.
• W2595688691 hasConceptScore W2595688691C17744445 @default.
• W2595688691 hasConceptScore W2595688691C190253527 @default.
• W2595688691 hasConceptScore W2595688691C2780035454 @default.
• W2595688691 hasConceptScore W2595688691C29122968 @default.
• W2595688691 hasConceptScore W2595688691C39549134 @default.
• W2595688691 hasConceptScore W2595688691C501593827 @default.
• W2595688691 hasConceptScore W2595688691C535046627 @default.
• W2595688691 hasConceptScore W2595688691C64903051 @default.
• W2595688691 hasConceptScore W2595688691C71924100 @default.
• W2595688691 hasConceptScore W2595688691C86803240 @default.
• W2595688691 hasConceptScore W2595688691C89423630 @default.
• W2595688691 hasConceptScore W2595688691C94665300 @default.
• W2595688691 hasConceptScore W2595688691C98274493 @default.
• W2595688691 hasIssue "2" @default.
• W2595688691 hasLocation W25956886911 @default.
• W2595688691 hasLocation W25956886912 @default.
• W2595688691 hasOpenAccess W2595688691 @default.
• W2595688691 hasPrimaryLocation W25956886911 @default.
• W2595688691 hasRelatedWork W2029063045 @default.
• W2595688691 hasRelatedWork W2076505260 @default.
• W2595688691 hasRelatedWork W2507683919 @default.
• W2595688691 hasRelatedWork W2748952813 @default.
• W2595688691 hasRelatedWork W2899084033 @default.
• W2595688691 hasRelatedWork W2955020749 @default.
• W2595688691 hasRelatedWork W4205293155 @default.
• W2595688691 hasRelatedWork W4226193097 @default.

• next