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- W2595794674 abstract "Background and aim: The diagnosis of small fibre neuropathy(SFN) is currently based on the clinical picture, quantitativesensory testing (QST), and autonomic function assessment. Adecreased density of intraepidermal innervation seem to bemorphological correlates of small-fibre dysfunction. The aim ofthis study was to compare intraepidermal nerve fibre (IENF)density in skin punch biopsy samples from a group of SFNpatients and from healthy volunteers, then to assess theinfluence of simultaneous large nerve-fibre involvement on IENFcounts. Methods: PGP 9.5-immunoreactive intraepidermal nervefibre (IENF) density was measured in 67 patients with painfulsensory neuropathy and in 25 healthy controls. All the patientssuffered from burning feet, and showed abnormal thermalthresholds on QST. Of the patients, 29 also revealedabnormities in nerve conduction studies and EMG examination,signs of large fibre involvement. Results: The mean IENF countper mm of epidermis was 5.8+-4.3 in the patients with largenerve fibre involvement, and 6.4+-3.3 in the patients withoutit (p=0.56). In the healthy volunteers, the mean IENF count wassignificantly higher (11.5+-2.9, p<0.001). Using a lower limitfor normal, at a level of 6.69 fibres per mm derived from thisgroup, an abnormal IENF count was present in 65% of patientswith pure SFN and in 69% of patients with involvement of bothsmall and large nerve fibres. Conclusions: IENF counts seem toparticularly reflect small nerve fibre status. Our findingstherefore corroborate the usefulness of IENF examination in SFNpatients." @default.
- W2595794674 created "2017-03-23" @default.
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- W2595794674 date "2005-01-01" @default.
- W2595794674 modified "2023-09-26" @default.
- W2595794674 title "Intra-epidermal nerve fibre density in patients with smallfibre polyneuropathy with and without simultaneous large fibreinvolvement" @default.
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