FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595815769> ?p ?o ?g. }

• W2595815769 endingPage "1324" @default.
• W2595815769 startingPage "1317" @default.
• W2595815769 abstract "BACKGROUND:The role that nc886, a non-coding microRNA, plays in human endometrial cancer is unknown. The present study aimed to describe the functional role of nc886 in human endometrial cancer-1A (HEC-1A) cell line, which may provide another target for human endometrial cancer treatment. MATERIAL AND METHODS:The expression levels of nv886 in normal human endometrial tissue and the early phase and late phase of human endometrial cancer tissues were determined and compared by fluorescence in situ hybridization (FISH). Small interference RNA (siRNA) was used to inhibit nc886, and cell proliferation was evaluated with the MTT test. mRNA levels of PKR, NF-κB, vascular endothelial growth factor (VEGF), and caspase-3 were determined against glyceraldehyde 3-phosphate dehydrogenase (GAPDH between the HEC-1A control group and the silenced group (nc886 silenced with siRNA) by real-time reverse transcription polymerase chain reaction (RT-PCR). The protein levels of PKR (total and phosphorylated form), NF-κB, VEGF, and caspase-3 were determined against GAPDH by Western blotting, and cell apoptosis was determined by flow cytometry. RESULTS:Our results indicated that a higher level of nc886 was expressed in the late phase of human endometrial cancer tissue, less than in the early phase but still higher than in normal human endometrial tissue. After nc886 was silenced, protein levels of p-PKR (phosphorylated PKR) and caspase-3 were increased, whereas NF-κB and VEGF were decreased. CONCLUSIONS:The rate of apoptosis in the silenced group was increased and the rate of cell proliferation was slower in comparison to the control." @default.
• W2595815769 created "2017-03-23" @default.
• W2595815769 creator A5056014255 @default.
• W2595815769 creator A5058691896 @default.
• W2595815769 creator A5079242766 @default.
• W2595815769 creator A5089455733 @default.
• W2595815769 creator A5091454180 @default.
• W2595815769 date "2017-03-16" @default.
• W2595815769 modified "2023-10-14" @default.
• W2595815769 title "Silencing nc886, a Non-Coding RNA, Induces Apoptosis of Human Endometrial Cancer Cells-1A In Vitro" @default.
• W2595815769 cites W1608176614 @default.
• W2595815769 cites W1669088940 @default.
• W2595815769 cites W1841811394 @default.
• W2595815769 cites W1970749368 @default.
• W2595815769 cites W1999341805 @default.
• W2595815769 cites W2000842673 @default.
• W2595815769 cites W2005698941 @default.
• W2595815769 cites W2008447167 @default.
• W2595815769 cites W2022969546 @default.
• W2595815769 cites W2053609448 @default.
• W2595815769 cites W2065831401 @default.
• W2595815769 cites W2076440683 @default.
• W2595815769 cites W2077112895 @default.
• W2595815769 cites W2077808289 @default.
• W2595815769 cites W2094373867 @default.
• W2595815769 cites W2118115617 @default.
• W2595815769 cites W2126706454 @default.
• W2595815769 cites W2144149602 @default.
• W2595815769 cites W2147764514 @default.
• W2595815769 cites W2151073330 @default.
• W2595815769 cites W2152296048 @default.
• W2595815769 cites W2164194749 @default.
• W2595815769 cites W2164349269 @default.
• W2595815769 cites W2171156915 @default.
• W2595815769 cites W2345600927 @default.
• W2595815769 cites W4247592462 @default.
• W2595815769 doi "https://doi.org/10.12659/msm.900320" @default.
• W2595815769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5365049" @default.
• W2595815769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28298621" @default.
• W2595815769 hasPublicationYear "2017" @default.
• W2595815769 type Work @default.
• W2595815769 sameAs 2595815769 @default.
• W2595815769 citedByCount "19" @default.
• W2595815769 countsByYear W25958157692017 @default.
• W2595815769 countsByYear W25958157692018 @default.
• W2595815769 countsByYear W25958157692019 @default.
• W2595815769 countsByYear W25958157692020 @default.
• W2595815769 countsByYear W25958157692021 @default.
• W2595815769 countsByYear W25958157692022 @default.
• W2595815769 countsByYear W25958157692023 @default.
• W2595815769 crossrefType "journal-article" @default.
• W2595815769 hasAuthorship W2595815769A5056014255 @default.
• W2595815769 hasAuthorship W2595815769A5058691896 @default.
• W2595815769 hasAuthorship W2595815769A5079242766 @default.
• W2595815769 hasAuthorship W2595815769A5089455733 @default.
• W2595815769 hasAuthorship W2595815769A5091454180 @default.
• W2595815769 hasBestOaLocation W25958157692 @default.
• W2595815769 hasConcept C104317684 @default.
• W2595815769 hasConcept C119056186 @default.
• W2595815769 hasConcept C121608353 @default.
• W2595815769 hasConcept C153911025 @default.
• W2595815769 hasConcept C167734588 @default.
• W2595815769 hasConcept C190283241 @default.
• W2595815769 hasConcept C22615655 @default.
• W2595815769 hasConcept C2777025900 @default.
• W2595815769 hasConcept C2777088508 @default.
• W2595815769 hasConcept C502942594 @default.
• W2595815769 hasConcept C54009773 @default.
• W2595815769 hasConcept C54355233 @default.
• W2595815769 hasConcept C55493867 @default.
• W2595815769 hasConcept C62112901 @default.
• W2595815769 hasConcept C81885089 @default.
• W2595815769 hasConcept C86803240 @default.
• W2595815769 hasConceptScore W2595815769C104317684 @default.
• W2595815769 hasConceptScore W2595815769C119056186 @default.
• W2595815769 hasConceptScore W2595815769C121608353 @default.
• W2595815769 hasConceptScore W2595815769C153911025 @default.
• W2595815769 hasConceptScore W2595815769C167734588 @default.
• W2595815769 hasConceptScore W2595815769C190283241 @default.
• W2595815769 hasConceptScore W2595815769C22615655 @default.
• W2595815769 hasConceptScore W2595815769C2777025900 @default.
• W2595815769 hasConceptScore W2595815769C2777088508 @default.
• W2595815769 hasConceptScore W2595815769C502942594 @default.
• W2595815769 hasConceptScore W2595815769C54009773 @default.
• W2595815769 hasConceptScore W2595815769C54355233 @default.
• W2595815769 hasConceptScore W2595815769C55493867 @default.
• W2595815769 hasConceptScore W2595815769C62112901 @default.
• W2595815769 hasConceptScore W2595815769C81885089 @default.
• W2595815769 hasConceptScore W2595815769C86803240 @default.
• W2595815769 hasLocation W25958157691 @default.
• W2595815769 hasLocation W25958157692 @default.
• W2595815769 hasLocation W25958157693 @default.
• W2595815769 hasLocation W25958157694 @default.
• W2595815769 hasOpenAccess W2595815769 @default.
• W2595815769 hasPrimaryLocation W25958157691 @default.
• W2595815769 hasRelatedWork W1973423407 @default.
• W2595815769 hasRelatedWork W1975676036 @default.
• W2595815769 hasRelatedWork W2060407805 @default.

• next