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• W2595847358 startingPage "352" @default.
• W2595847358 abstract "A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality in vitro, in vivo ecotoxicological and in vivo mammalian toxicological studies. Epidemiological studies were also considered. Toxicokinetic data provided the basis for determining rational cutoffs above which exposures were considered irrelevant to humans based on exceeding thresholds for saturation of renal clearance (TSRC); extensive human exposure and biomonitoring data support that these boundaries far exceed human exposures and provide ample margins of exposure. 2,4-D showed no evidence of interacting with the estrogen or androgen pathways. 2,4-D interacts with the thyroid axis in rats through displacement of thyroxine from plasma binding sites only at high doses exceeding the TSRC in mammals. 2,4-D effects on steroidogenesis parameters are likely related to high-dose specific systemic toxicity at doses exceeding the TSRC and are not likely to be endocrine mediated. No studies, including high quality studies in the published literature, predict significant endocrine-related toxicity or functional decrements in any species at environmentally relevant concentrations, or, in mammals, at doses below the TSRC that are relevant for human hazard and risk assessment. Overall, there is no basis for concern regarding potential interactions of 2,4-D with endocrine pathways or axes (estrogen, androgen, steroidogenesis or thyroid), and thus 2,4-D is unlikely to pose a threat from endocrine disruption to wildlife or humans under conditions of real-world exposures." @default.
• W2595847358 created "2017-03-23" @default.
• W2595847358 creator A5069529593 @default.
• W2595847358 creator A5071853821 @default.
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• W2595847358 creator A5079542999 @default.
• W2595847358 creator A5082374746 @default.
• W2595847358 creator A5086673323 @default.
• W2595847358 date "2017-03-02" @default.
• W2595847358 modified "2023-10-17" @default.
• W2595847358 title "Weight-of-the-evidence evaluation of 2,4-D potential for interactions with the estrogen, androgen and thyroid pathways and steroidogenesis" @default.
• W2595847358 cites W1416869628 @default.
• W2595847358 cites W1513550542 @default.
• W2595847358 cites W1535188141 @default.
• W2595847358 cites W1605584477 @default.
• W2595847358 cites W1874712752 @default.
• W2595847358 cites W1964804675 @default.
• W2595847358 cites W1965100241 @default.
• W2595847358 cites W1966446943 @default.
• W2595847358 cites W1968785692 @default.
• W2595847358 cites W1969190878 @default.
• W2595847358 cites W1970197319 @default.
• W2595847358 cites W1971454422 @default.
• W2595847358 cites W1972632058 @default.
• W2595847358 cites W1976807914 @default.
• W2595847358 cites W1978246465 @default.
• W2595847358 cites W1982026267 @default.
• W2595847358 cites W1982784217 @default.
• W2595847358 cites W1984159923 @default.
• W2595847358 cites W1985934336 @default.
• W2595847358 cites W1986497254 @default.
• W2595847358 cites W1988784069 @default.
• W2595847358 cites W1988876627 @default.
• W2595847358 cites W1990202828 @default.
• W2595847358 cites W1992983589 @default.
• W2595847358 cites W1995085526 @default.
• W2595847358 cites W1997506012 @default.
• W2595847358 cites W1999897132 @default.
• W2595847358 cites W2001508640 @default.
• W2595847358 cites W2001800469 @default.
• W2595847358 cites W2002553752 @default.
• W2595847358 cites W2002886022 @default.
• W2595847358 cites W2004595929 @default.
• W2595847358 cites W2006217040 @default.
• W2595847358 cites W2006532904 @default.
• W2595847358 cites W2006896521 @default.
• W2595847358 cites W2007004876 @default.
• W2595847358 cites W2009930090 @default.
• W2595847358 cites W2010902079 @default.
• W2595847358 cites W2011002725 @default.
• W2595847358 cites W2011188574 @default.
• W2595847358 cites W2017300930 @default.
• W2595847358 cites W2018088183 @default.
• W2595847358 cites W2019148051 @default.
• W2595847358 cites W2020215852 @default.
• W2595847358 cites W2022024669 @default.
• W2595847358 cites W2022925851 @default.
• W2595847358 cites W2023592880 @default.
• W2595847358 cites W2027119624 @default.
• W2595847358 cites W2031742072 @default.
• W2595847358 cites W2033115653 @default.
• W2595847358 cites W2034761114 @default.
• W2595847358 cites W2034849428 @default.
• W2595847358 cites W2035479896 @default.
• W2595847358 cites W2036641359 @default.
• W2595847358 cites W2046249604 @default.
• W2595847358 cites W2046800609 @default.
• W2595847358 cites W2047846515 @default.
• W2595847358 cites W2048192376 @default.
• W2595847358 cites W2051917964 @default.
• W2595847358 cites W2053362766 @default.
• W2595847358 cites W2053969183 @default.
• W2595847358 cites W2058235057 @default.
• W2595847358 cites W2060888149 @default.
• W2595847358 cites W2061611346 @default.
• W2595847358 cites W2065714069 @default.
• W2595847358 cites W2065921259 @default.
• W2595847358 cites W2066625940 @default.
• W2595847358 cites W2068279775 @default.
• W2595847358 cites W2070228542 @default.
• W2595847358 cites W2076423263 @default.
• W2595847358 cites W2076904650 @default.
• W2595847358 cites W2078034047 @default.
• W2595847358 cites W2079379867 @default.
• W2595847358 cites W2079712252 @default.
• W2595847358 cites W2079918321 @default.
• W2595847358 cites W2080961461 @default.
• W2595847358 cites W2082054968 @default.
• W2595847358 cites W2083246945 @default.
• W2595847358 cites W2083462441 @default.
• W2595847358 cites W2085740934 @default.
• W2595847358 cites W2090582095 @default.
• W2595847358 cites W2091571490 @default.
• W2595847358 cites W2094654319 @default.
• W2595847358 cites W2095624294 @default.
• W2595847358 cites W2097461167 @default.
• W2595847358 cites W2103299597 @default.
• W2595847358 cites W2105053821 @default.

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