Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595891294> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2595891294 abstract "Pentose phosphate pathway (PPP) belongs to the potentialtargets for the treatment of diabetic microvascularcomplications. Activation of transketolase (TKT), the keyenzyme of non-oxidative branch of PPP, using thiaminesupplementation prevents development and progression ofdiabetic nephropathy in animal model of diabetes. Thiaminewhich serves as a cofactor for TKT is delivered to the cell viaspecific thiamine transporters 1 (THTR 1 encoded by the geneSLC19A2) and 2 (THTR 2 encoded by SLC19A3). Plasma thiaminelevels in diabetics are decreased due to increased thiaminerenal clearance. We have recently demonstrated rise of plasmathiamine in subjects with decreased renal function, however, wedid not show parallel increase of intracellular active cofactor[Pacal et al. Nephrol Dial Transplant 2011]. Therefore wepropose that major abnormalities in thiamine metabolism mostlikely take place on the level of thiamine transport into thecell. SNPs in the genes for the thiamine transporters maypotentially affect activity of thiamine transport and thuscontribute to the progression of DN. The aim of our study wasto analyze relationship between genetic variability in SLC19A2and SLC19A3 loci and diabetes-related morbidity and mortality." @default.
- W2595891294 created "2017-03-23" @default.
- W2595891294 creator A5016505714 @default.
- W2595891294 creator A5025130031 @default.
- W2595891294 creator A5038317007 @default.
- W2595891294 creator A5045796840 @default.
- W2595891294 creator A5047885441 @default.
- W2595891294 creator A5054252836 @default.
- W2595891294 creator A5059820536 @default.
- W2595891294 creator A5071640431 @default.
- W2595891294 creator A5080242241 @default.
- W2595891294 creator A5090402035 @default.
- W2595891294 date "2013-01-01" @default.
- W2595891294 modified "2023-10-18" @default.
- W2595891294 title "Variation in the genes for thiamine transporters is not a riskfactor for diabetes-related morbidity and mortality" @default.
- W2595891294 hasPublicationYear "2013" @default.
- W2595891294 type Work @default.
- W2595891294 sameAs 2595891294 @default.
- W2595891294 citedByCount "0" @default.
- W2595891294 crossrefType "journal-article" @default.
- W2595891294 hasAuthorship W2595891294A5016505714 @default.
- W2595891294 hasAuthorship W2595891294A5025130031 @default.
- W2595891294 hasAuthorship W2595891294A5038317007 @default.
- W2595891294 hasAuthorship W2595891294A5045796840 @default.
- W2595891294 hasAuthorship W2595891294A5047885441 @default.
- W2595891294 hasAuthorship W2595891294A5054252836 @default.
- W2595891294 hasAuthorship W2595891294A5059820536 @default.
- W2595891294 hasAuthorship W2595891294A5071640431 @default.
- W2595891294 hasAuthorship W2595891294A5080242241 @default.
- W2595891294 hasAuthorship W2595891294A5090402035 @default.
- W2595891294 hasConcept C103432212 @default.
- W2595891294 hasConcept C126322002 @default.
- W2595891294 hasConcept C134018914 @default.
- W2595891294 hasConcept C181199279 @default.
- W2595891294 hasConcept C197957613 @default.
- W2595891294 hasConcept C20251656 @default.
- W2595891294 hasConcept C2776203871 @default.
- W2595891294 hasConcept C2780047943 @default.
- W2595891294 hasConcept C3409486 @default.
- W2595891294 hasConcept C55493867 @default.
- W2595891294 hasConcept C555293320 @default.
- W2595891294 hasConcept C62231903 @default.
- W2595891294 hasConcept C71924100 @default.
- W2595891294 hasConcept C86803240 @default.
- W2595891294 hasConceptScore W2595891294C103432212 @default.
- W2595891294 hasConceptScore W2595891294C126322002 @default.
- W2595891294 hasConceptScore W2595891294C134018914 @default.
- W2595891294 hasConceptScore W2595891294C181199279 @default.
- W2595891294 hasConceptScore W2595891294C197957613 @default.
- W2595891294 hasConceptScore W2595891294C20251656 @default.
- W2595891294 hasConceptScore W2595891294C2776203871 @default.
- W2595891294 hasConceptScore W2595891294C2780047943 @default.
- W2595891294 hasConceptScore W2595891294C3409486 @default.
- W2595891294 hasConceptScore W2595891294C55493867 @default.
- W2595891294 hasConceptScore W2595891294C555293320 @default.
- W2595891294 hasConceptScore W2595891294C62231903 @default.
- W2595891294 hasConceptScore W2595891294C71924100 @default.
- W2595891294 hasConceptScore W2595891294C86803240 @default.
- W2595891294 hasLocation W25958912941 @default.
- W2595891294 hasOpenAccess W2595891294 @default.
- W2595891294 hasPrimaryLocation W25958912941 @default.
- W2595891294 hasRelatedWork W198472986 @default.
- W2595891294 hasRelatedWork W2025817795 @default.
- W2595891294 hasRelatedWork W2040023013 @default.
- W2595891294 hasRelatedWork W2055990009 @default.
- W2595891294 hasRelatedWork W2058026968 @default.
- W2595891294 hasRelatedWork W2073783015 @default.
- W2595891294 hasRelatedWork W2170904194 @default.
- W2595891294 hasRelatedWork W2237050689 @default.
- W2595891294 hasRelatedWork W2362653257 @default.
- W2595891294 hasRelatedWork W2578762276 @default.
- W2595891294 isParatext "false" @default.
- W2595891294 isRetracted "false" @default.
- W2595891294 magId "2595891294" @default.
- W2595891294 workType "article" @default.