Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595961818> ?p ?o ?g. }
- W2595961818 endingPage "949" @default.
- W2595961818 startingPage "936" @default.
- W2595961818 abstract "With the rapidly growing number of sequenced microbial (meta)genomes, enormous cryptic natural product (NP) biosynthetic gene clusters (BGCs) have been identified, which are regarded as a rich reservoir for novel drug discovery. A series of powerful tools for engineering BGCs has accelerated the discovery and development of pharmaceutically active NPs. Here, we describe recent advances in the strategies for BGCs manipulation, which are driven by emerging technologies, including efficient DNA recombination systems, versatile CRISPR/Cas9 genome editing tools and diverse DNA assembly methods. We further discuss how these approaches could be used for genome mining studies and industrial strain improvement." @default.
- W2595961818 created "2017-03-23" @default.
- W2595961818 creator A5007492684 @default.
- W2595961818 creator A5077718901 @default.
- W2595961818 creator A5086980325 @default.
- W2595961818 date "2017-12-01" @default.
- W2595961818 modified "2023-10-17" @default.
- W2595961818 title "New strategies and approaches for engineering biosynthetic gene clusters of microbial natural products" @default.
- W2595961818 cites W1202680985 @default.
- W2595961818 cites W1213974439 @default.
- W2595961818 cites W1495243007 @default.
- W2595961818 cites W1501067566 @default.
- W2595961818 cites W1555471169 @default.
- W2595961818 cites W1598992418 @default.
- W2595961818 cites W1769058900 @default.
- W2595961818 cites W1787875571 @default.
- W2595961818 cites W1827213771 @default.
- W2595961818 cites W1908709110 @default.
- W2595961818 cites W1943821519 @default.
- W2595961818 cites W1948947423 @default.
- W2595961818 cites W1950503156 @default.
- W2595961818 cites W1955991317 @default.
- W2595961818 cites W1967210731 @default.
- W2595961818 cites W1967382476 @default.
- W2595961818 cites W1967940125 @default.
- W2595961818 cites W1968867727 @default.
- W2595961818 cites W1971439989 @default.
- W2595961818 cites W1977463604 @default.
- W2595961818 cites W1979049096 @default.
- W2595961818 cites W1979320224 @default.
- W2595961818 cites W1982784580 @default.
- W2595961818 cites W1990935073 @default.
- W2595961818 cites W1993330603 @default.
- W2595961818 cites W1994028898 @default.
- W2595961818 cites W1997061512 @default.
- W2595961818 cites W1998348841 @default.
- W2595961818 cites W2004809474 @default.
- W2595961818 cites W2009257824 @default.
- W2595961818 cites W2012960603 @default.
- W2595961818 cites W2013583230 @default.
- W2595961818 cites W2014185755 @default.
- W2595961818 cites W2014637330 @default.
- W2595961818 cites W2018371219 @default.
- W2595961818 cites W2023950913 @default.
- W2595961818 cites W2024828771 @default.
- W2595961818 cites W2026971762 @default.
- W2595961818 cites W2028367976 @default.
- W2595961818 cites W2029583307 @default.
- W2595961818 cites W2031052993 @default.
- W2595961818 cites W2036456980 @default.
- W2595961818 cites W2041537722 @default.
- W2595961818 cites W2044608678 @default.
- W2595961818 cites W2045435533 @default.
- W2595961818 cites W2045785445 @default.
- W2595961818 cites W2046976964 @default.
- W2595961818 cites W2051013972 @default.
- W2595961818 cites W2063266152 @default.
- W2595961818 cites W2064466082 @default.
- W2595961818 cites W2066550363 @default.
- W2595961818 cites W2068815648 @default.
- W2595961818 cites W2078628363 @default.
- W2595961818 cites W2084447564 @default.
- W2595961818 cites W2086232077 @default.
- W2595961818 cites W2088629793 @default.
- W2595961818 cites W2092485142 @default.
- W2595961818 cites W2096261947 @default.
- W2595961818 cites W2102440675 @default.
- W2595961818 cites W2107879606 @default.
- W2595961818 cites W2109881867 @default.
- W2595961818 cites W2113000430 @default.
- W2595961818 cites W2113868159 @default.
- W2595961818 cites W2115015715 @default.
- W2595961818 cites W2116137883 @default.
- W2595961818 cites W2118532777 @default.
- W2595961818 cites W2119829779 @default.
- W2595961818 cites W2119933619 @default.
- W2595961818 cites W2124658399 @default.
- W2595961818 cites W2129203537 @default.
- W2595961818 cites W2129687158 @default.
- W2595961818 cites W2130083654 @default.
- W2595961818 cites W2136670217 @default.
- W2595961818 cites W2140786937 @default.
- W2595961818 cites W2141946944 @default.
- W2595961818 cites W2142663960 @default.
- W2595961818 cites W2143999510 @default.
- W2595961818 cites W2144579030 @default.
- W2595961818 cites W2145741131 @default.
- W2595961818 cites W2149220857 @default.
- W2595961818 cites W2150665661 @default.
- W2595961818 cites W2160253662 @default.
- W2595961818 cites W2165497812 @default.
- W2595961818 cites W2166907286 @default.
- W2595961818 cites W2173236730 @default.
- W2595961818 cites W2178324140 @default.
- W2595961818 cites W2181255358 @default.
- W2595961818 cites W2187341651 @default.
- W2595961818 cites W2188223075 @default.
- W2595961818 cites W2190116331 @default.