FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595963844> ?p ?o ?g. }

• W2595963844 abstract "10558 Background: HER-2 overexpression is associated to a poor prognosis in high-risk and MBC patients treated with HDC. HER-2 status is also a predictive factor of response to trastuzumab: when trastuzumab is administered in combination with or sequentially to chemotherapy, a significant DFS and/or survival improvement has been observed in HER2+ early and MBC. Unfortunately, in both settings, trastuzumab was associated with an increased risk of cardiac dysfunctions (CD). Patients and Methods: In order to evaluate the cardiac safety of trastuzumab after HDC, we have reviewed the clinical charts of HER2-overexpressing MBC patients treated with HDC and trastuzumab at 11 centres of the GITMO group. Age, baseline LVEF, radiation therapy on cardiac area, exposure to anthracycline, single or multiple transplant, high-dose agents, trastuzumab treatment duration were recorded as potential risk factors. Cardiac dysfunction (CD) was defined as: 1) decline of LVEF ≥ 10% to below 50%, 2) decline of LVEF between 5 and 9% to below 50% with symptomatic (NYHA class III-IV) congestive heart failure (CHF), 3) any symptomatic CHF event. Results: Fifty-three patients treated between 1999 and 2005 have been included in the analysis. Median age was 47 years (range 29–66). Median interval between HDC and trastuzumab was 6 months. Median LVEF at baseline was 60.5%; at the end of trastuzumab (data available for 28 patients only) it was 55% (p = 0.01). Five out of the 28 (17.9%) pts experienced CD. Two out of 53 (3.8%) pts developed a symptomatic (NYHA class III) CHF. Age ≥ 50 years was the only factor significantly associated with CD. However age ≥ 50 years and multiple transplant procedure were associated with a significant decline of LVEF (p: 0.02). Conclusion: The incidence of CD is not superior to that reported with trastuzumab after standard chemotherapy. However pts with age ≥ 50 years or receiving multiple course of HDC, should be considered at risk for CD. No significant financial relationships to disclose." @default.
• W2595963844 created "2017-03-23" @default.
• W2595963844 creator A5018118709 @default.
• W2595963844 creator A5018743880 @default.
• W2595963844 creator A5025848846 @default.
• W2595963844 creator A5063562719 @default.
• W2595963844 creator A5065961744 @default.
• W2595963844 creator A5075911054 @default.
• W2595963844 creator A5078260568 @default.
• W2595963844 creator A5085501918 @default.
• W2595963844 creator A5086116060 @default.
• W2595963844 creator A5089288192 @default.
• W2595963844 creator A5089884124 @default.
• W2595963844 date "2006-06-20" @default.
• W2595963844 modified "2023-09-27" @default.
• W2595963844 title "Cardiac tolerability of trastuzumab in metastatic breast cancer (MBC) patients previously treated with high-dose chemotherapy (HDC) with autologous hemopoietic support: Retrospective analysis from Gruppo Italiano Trapianto Midollo Osseo (GITMO) Solid Tumor Working Party" @default.
• W2595963844 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.10558" @default.
• W2595963844 hasPublicationYear "2006" @default.
• W2595963844 type Work @default.
• W2595963844 sameAs 2595963844 @default.
• W2595963844 citedByCount "1" @default.
• W2595963844 countsByYear W25959638442013 @default.
• W2595963844 crossrefType "journal-article" @default.
• W2595963844 hasAuthorship W2595963844A5018118709 @default.
• W2595963844 hasAuthorship W2595963844A5018743880 @default.
• W2595963844 hasAuthorship W2595963844A5025848846 @default.
• W2595963844 hasAuthorship W2595963844A5063562719 @default.
• W2595963844 hasAuthorship W2595963844A5065961744 @default.
• W2595963844 hasAuthorship W2595963844A5075911054 @default.
• W2595963844 hasAuthorship W2595963844A5078260568 @default.
• W2595963844 hasAuthorship W2595963844A5085501918 @default.
• W2595963844 hasAuthorship W2595963844A5086116060 @default.
• W2595963844 hasAuthorship W2595963844A5089288192 @default.
• W2595963844 hasAuthorship W2595963844A5089884124 @default.
• W2595963844 hasConcept C121608353 @default.
• W2595963844 hasConcept C126322002 @default.
• W2595963844 hasConcept C141071460 @default.
• W2595963844 hasConcept C143998085 @default.
• W2595963844 hasConcept C197934379 @default.
• W2595963844 hasConcept C2775930923 @default.
• W2595963844 hasConcept C2776694085 @default.
• W2595963844 hasConcept C2776802502 @default.
• W2595963844 hasConcept C2778198053 @default.
• W2595963844 hasConcept C2778375690 @default.
• W2595963844 hasConcept C2779786085 @default.
• W2595963844 hasConcept C530470458 @default.
• W2595963844 hasConcept C71924100 @default.
• W2595963844 hasConcept C78085059 @default.
• W2595963844 hasConceptScore W2595963844C121608353 @default.
• W2595963844 hasConceptScore W2595963844C126322002 @default.
• W2595963844 hasConceptScore W2595963844C141071460 @default.
• W2595963844 hasConceptScore W2595963844C143998085 @default.
• W2595963844 hasConceptScore W2595963844C197934379 @default.
• W2595963844 hasConceptScore W2595963844C2775930923 @default.
• W2595963844 hasConceptScore W2595963844C2776694085 @default.
• W2595963844 hasConceptScore W2595963844C2776802502 @default.
• W2595963844 hasConceptScore W2595963844C2778198053 @default.
• W2595963844 hasConceptScore W2595963844C2778375690 @default.
• W2595963844 hasConceptScore W2595963844C2779786085 @default.
• W2595963844 hasConceptScore W2595963844C530470458 @default.
• W2595963844 hasConceptScore W2595963844C71924100 @default.
• W2595963844 hasConceptScore W2595963844C78085059 @default.
• W2595963844 hasLocation W25959638441 @default.
• W2595963844 hasOpenAccess W2595963844 @default.
• W2595963844 hasPrimaryLocation W25959638441 @default.
• W2595963844 hasRelatedWork W1937628254 @default.
• W2595963844 hasRelatedWork W1971716849 @default.
• W2595963844 hasRelatedWork W1976609613 @default.
• W2595963844 hasRelatedWork W2013223170 @default.
• W2595963844 hasRelatedWork W2030434439 @default.
• W2595963844 hasRelatedWork W2050439103 @default.
• W2595963844 hasRelatedWork W2082219531 @default.
• W2595963844 hasRelatedWork W2218005127 @default.
• W2595963844 hasRelatedWork W2591616149 @default.
• W2595963844 hasRelatedWork W4212973790 @default.
• W2595963844 isParatext "false" @default.
• W2595963844 isRetracted "false" @default.
• W2595963844 magId "2595963844" @default.
• W2595963844 workType "article" @default.