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- W2596054013 endingPage "436" @default.
- W2596054013 startingPage "428" @default.
- W2596054013 abstract "Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source of energy and biosynthetic molecules. The transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment and signaling via HIF-1α and AHR regulate the metabolism of gliomas and immune cells, modulating tumor-specific immunity and, consequently, tumor growth. Here, we review the roles of HIF-1α and AHR in cancer and immune cell metabolism in GBM." @default.
- W2596054013 created "2017-03-23" @default.
- W2596054013 creator A5001353818 @default.
- W2596054013 creator A5021075992 @default.
- W2596054013 creator A5035185964 @default.
- W2596054013 creator A5045949543 @default.
- W2596054013 date "2017-06-01" @default.
- W2596054013 modified "2023-10-17" @default.
- W2596054013 title "Role of AHR and HIF-1α in Glioblastoma Metabolism" @default.
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