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- W2596079142 abstract "The cells at the human maternal-fetal interface that engage in the placental-immune dialog have been studied extensively, where HLA-G-expressing trophoblasts and putative targets (natural killer (NK) cells, macrophages, T cells) are readily available for in vitro studies. However, the significance of MHC-leukocyte interactions for pregnancy success is exceedingly difficult to interrogate with human in vivo studies. We have developed two approaches for studying the trophoblast-leukocyte dialog in vivo in the rhesus monkey, where the primary trophoblast MHC class I molecule, Mamu-AG, is considered homologous to HLA-G. Recent passive immunization studies with anti-Mamu-AG antibodies have demonstrated disruption of placental villous growth, decidual differentiation, and spiral arteriole remodelling by endovascular trophoblasts, in vivo evidence of a physiological role in early pregnancy. Taking a cue from success with this approach, we have adapted immunodepletion of peripheral blood leukocytes with rhesus monkeys as an approach to modulate the endometrial and decidual populations. Successful paradigms for depleting peripheral blood NK cells have been established, and although studies are in the early stages, changes in endometrial/decidual leukocyte populations, vascularization, and glandular and stromal differentiation with immunodepletion support the hypothesis that leukocytes play an important role in implantation and the establishment of a successful pregnancy. In addition, initial results suggest that nonhuman primate implantation is sensitive to immune manipulation and could provide a model for early pregnancy loss. (platform)" @default.
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- W2596079142 date "2010-11-01" @default.
- W2596079142 modified "2023-09-26" @default.
- W2596079142 title "Maternal-Fetal Immune Dialog in Nonhuman Primates." @default.
- W2596079142 doi "https://doi.org/10.1093/biolreprod/83.s1.112" @default.
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