Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596103622> ?p ?o ?g. }
- W2596103622 endingPage "551" @default.
- W2596103622 startingPage "541" @default.
- W2596103622 abstract "Inflammatory bowel diseases involve the dynamic interaction of host genetics, the microbiome and inflammatory responses. Here we found lower expression of NLRP12 (which encodes a negative regulator of innate immunity) in human ulcerative colitis, by comparing monozygotic twins and other patient cohorts. In parallel, Nlrp12 deficiency in mice caused increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective gut commensal strains (of the family Lachnospiraceae) and a greater abundance of colitogenic strains (of the family Erysipelotrichaceae). Dysbiosis and susceptibility to colitis associated with Nlrp12 deficency were reversed equally by treatment with antibodies targeting inflammatory cytokines and by the administration of beneficial commensal Lachnospiraceae isolates. Fecal transplants from mice reared in specific-pathogen-free conditions into germ-free Nlrp12-deficient mice showed that NLRP12 and the microbiome each contributed to immunological signaling that culminated in colon inflammation. These findings reveal a feed-forward loop in which NLRP12 promotes specific commensals that can reverse gut inflammation, while cytokine blockade during NLRP12 deficiency can reverse dysbiosis." @default.
- W2596103622 created "2017-03-23" @default.
- W2596103622 creator A5018851197 @default.
- W2596103622 creator A5031730435 @default.
- W2596103622 creator A5040446707 @default.
- W2596103622 creator A5049294221 @default.
- W2596103622 creator A5049586381 @default.
- W2596103622 creator A5049638009 @default.
- W2596103622 creator A5061095526 @default.
- W2596103622 creator A5062608685 @default.
- W2596103622 creator A5074209018 @default.
- W2596103622 creator A5074446092 @default.
- W2596103622 creator A5078183836 @default.
- W2596103622 creator A5079252184 @default.
- W2596103622 creator A5079488262 @default.
- W2596103622 creator A5081912711 @default.
- W2596103622 date "2017-03-13" @default.
- W2596103622 modified "2023-10-14" @default.
- W2596103622 title "NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth" @default.
- W2596103622 cites W1642457845 @default.
- W2596103622 cites W1670573097 @default.
- W2596103622 cites W1970287311 @default.
- W2596103622 cites W1971308765 @default.
- W2596103622 cites W1981197190 @default.
- W2596103622 cites W1982600957 @default.
- W2596103622 cites W1990590570 @default.
- W2596103622 cites W1993399595 @default.
- W2596103622 cites W1994348473 @default.
- W2596103622 cites W1995924556 @default.
- W2596103622 cites W1996148181 @default.
- W2596103622 cites W1998990856 @default.
- W2596103622 cites W2003342633 @default.
- W2596103622 cites W2004549986 @default.
- W2596103622 cites W2009170813 @default.
- W2596103622 cites W2024192805 @default.
- W2596103622 cites W2025371570 @default.
- W2596103622 cites W2028145763 @default.
- W2596103622 cites W2029705820 @default.
- W2596103622 cites W2032661113 @default.
- W2596103622 cites W2052714671 @default.
- W2596103622 cites W2060185417 @default.
- W2596103622 cites W2068126966 @default.
- W2596103622 cites W2071496192 @default.
- W2596103622 cites W2077590888 @default.
- W2596103622 cites W2085284704 @default.
- W2596103622 cites W2092083061 @default.
- W2596103622 cites W2095151808 @default.
- W2596103622 cites W2097515723 @default.
- W2596103622 cites W2097875133 @default.
- W2596103622 cites W2099266276 @default.
- W2596103622 cites W2121722333 @default.
- W2596103622 cites W2122459017 @default.
- W2596103622 cites W2128444087 @default.
- W2596103622 cites W2138801049 @default.
- W2596103622 cites W2144275312 @default.
- W2596103622 cites W2144709035 @default.
- W2596103622 cites W2147140120 @default.
- W2596103622 cites W2150781849 @default.
- W2596103622 cites W2152885278 @default.
- W2596103622 cites W2161332823 @default.
- W2596103622 cites W2161533969 @default.
- W2596103622 cites W2165279431 @default.
- W2596103622 cites W2167927725 @default.
- W2596103622 cites W2169978950 @default.
- W2596103622 cites W2174316710 @default.
- W2596103622 cites W2294126626 @default.
- W2596103622 cites W2484230073 @default.
- W2596103622 cites W2534977774 @default.
- W2596103622 cites W268488872 @default.
- W2596103622 cites W2995380442 @default.
- W2596103622 doi "https://doi.org/10.1038/ni.3690" @default.
- W2596103622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5395345" @default.
- W2596103622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29044233" @default.
- W2596103622 hasPublicationYear "2017" @default.
- W2596103622 type Work @default.
- W2596103622 sameAs 2596103622 @default.
- W2596103622 citedByCount "199" @default.
- W2596103622 countsByYear W25961036222017 @default.
- W2596103622 countsByYear W25961036222018 @default.
- W2596103622 countsByYear W25961036222019 @default.
- W2596103622 countsByYear W25961036222020 @default.
- W2596103622 countsByYear W25961036222021 @default.
- W2596103622 countsByYear W25961036222022 @default.
- W2596103622 countsByYear W25961036222023 @default.
- W2596103622 crossrefType "journal-article" @default.
- W2596103622 hasAuthorship W2596103622A5018851197 @default.
- W2596103622 hasAuthorship W2596103622A5031730435 @default.
- W2596103622 hasAuthorship W2596103622A5040446707 @default.
- W2596103622 hasAuthorship W2596103622A5049294221 @default.
- W2596103622 hasAuthorship W2596103622A5049586381 @default.
- W2596103622 hasAuthorship W2596103622A5049638009 @default.
- W2596103622 hasAuthorship W2596103622A5061095526 @default.
- W2596103622 hasAuthorship W2596103622A5062608685 @default.
- W2596103622 hasAuthorship W2596103622A5074209018 @default.
- W2596103622 hasAuthorship W2596103622A5074446092 @default.
- W2596103622 hasAuthorship W2596103622A5078183836 @default.
- W2596103622 hasAuthorship W2596103622A5079252184 @default.
- W2596103622 hasAuthorship W2596103622A5079488262 @default.