Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596178227> ?p ?o ?g. }
- W2596178227 endingPage "711" @default.
- W2596178227 startingPage "693" @default.
- W2596178227 abstract "Diabetic cardiomyopathy (DCM) was first recognized more than four decades ago and occurred independent of cardiovascular diseases or hypertension in both type 1 and type 2 diabetic patients. The exact mechanisms underlying this disease remain incompletely understood. Several pathophysiological bases responsible for DCM have been proposed, including the presence of hyperglycemia, nonenzymatic glycosylation of large molecules (e.g., proteins), energy metabolic disturbance, mitochondrial damage and dysfunction, impaired calcium handling, reactive oxygen species formation, inflammation, cardiac cell death, and cardiac hypertrophy and fibrosis, leading to impairment of cardiac contractile functions. Increasing evidence also indicates the phenomenon called metabolic memory for diabetes-induced cardiovascular complications, for which epigenetic modulation seemed to play an important role, suggesting that the aforementioned pathogenic bases may be regulated by epigenetic modification. Therefore, this review aims at briefly summarizing the current understanding of the pathophysiological bases for DCM. Although how epigenetic mechanisms play a role remains incompletely understood now, extensive clinical and experimental studies have implicated its importance in regulating the cardiac responses to diabetes, which are believed to shed insight into understanding of the pathophysiological and epigenetic mechanisms for the development of DCM and its possible prevention and/or therapy. © 2017 American Physiological Society. Compr Physiol 7:693-711, 2017." @default.
- W2596178227 created "2017-03-23" @default.
- W2596178227 creator A5017873319 @default.
- W2596178227 creator A5044898446 @default.
- W2596178227 creator A5058670046 @default.
- W2596178227 creator A5059015054 @default.
- W2596178227 creator A5060886735 @default.
- W2596178227 creator A5061035980 @default.
- W2596178227 date "2017-03-16" @default.
- W2596178227 modified "2023-10-13" @default.
- W2596178227 title "Pathophysiological Fundamentals of Diabetic Cardiomyopathy" @default.
- W2596178227 cites W1035140252 @default.
- W2596178227 cites W1526927233 @default.
- W2596178227 cites W1540651760 @default.
- W2596178227 cites W1595491423 @default.
- W2596178227 cites W1671465572 @default.
- W2596178227 cites W172609984 @default.
- W2596178227 cites W1752045965 @default.
- W2596178227 cites W1862799510 @default.
- W2596178227 cites W1908141864 @default.
- W2596178227 cites W1911836119 @default.
- W2596178227 cites W1963883680 @default.
- W2596178227 cites W1964979010 @default.
- W2596178227 cites W1968572097 @default.
- W2596178227 cites W1972670427 @default.
- W2596178227 cites W1972782439 @default.
- W2596178227 cites W1974581522 @default.
- W2596178227 cites W1975209874 @default.
- W2596178227 cites W1976119788 @default.
- W2596178227 cites W1976197221 @default.
- W2596178227 cites W1978139051 @default.
- W2596178227 cites W1980391873 @default.
- W2596178227 cites W1982079739 @default.
- W2596178227 cites W1983049049 @default.
- W2596178227 cites W1984193593 @default.
- W2596178227 cites W1985402074 @default.
- W2596178227 cites W1986276307 @default.
- W2596178227 cites W1986721569 @default.
- W2596178227 cites W1987940856 @default.
- W2596178227 cites W1989101440 @default.
- W2596178227 cites W1989454102 @default.
- W2596178227 cites W1990900148 @default.
- W2596178227 cites W1991430539 @default.
- W2596178227 cites W1991451322 @default.
- W2596178227 cites W1992564227 @default.
- W2596178227 cites W1992713540 @default.
- W2596178227 cites W1994127329 @default.
- W2596178227 cites W1995675654 @default.
- W2596178227 cites W1996376927 @default.
- W2596178227 cites W1996954632 @default.
- W2596178227 cites W1997433778 @default.
- W2596178227 cites W1998746878 @default.
- W2596178227 cites W1999273706 @default.
- W2596178227 cites W2000740288 @default.
- W2596178227 cites W2002257186 @default.
- W2596178227 cites W2002938395 @default.
- W2596178227 cites W2004172747 @default.
- W2596178227 cites W2004440478 @default.
- W2596178227 cites W2005033167 @default.
- W2596178227 cites W2005272368 @default.
- W2596178227 cites W2005859751 @default.
- W2596178227 cites W2006247039 @default.
- W2596178227 cites W2006499762 @default.
- W2596178227 cites W2006856548 @default.
- W2596178227 cites W2007248715 @default.
- W2596178227 cites W2007441754 @default.
- W2596178227 cites W2008749934 @default.
- W2596178227 cites W2010261601 @default.
- W2596178227 cites W2010946386 @default.
- W2596178227 cites W2011068925 @default.
- W2596178227 cites W2012070284 @default.
- W2596178227 cites W2012314430 @default.
- W2596178227 cites W2012506183 @default.
- W2596178227 cites W2012732674 @default.
- W2596178227 cites W2012937190 @default.
- W2596178227 cites W2014772837 @default.
- W2596178227 cites W2016523434 @default.
- W2596178227 cites W2016751278 @default.
- W2596178227 cites W2019987942 @default.
- W2596178227 cites W2021458745 @default.
- W2596178227 cites W2021968322 @default.
- W2596178227 cites W2024751299 @default.
- W2596178227 cites W2024943263 @default.
- W2596178227 cites W2025827803 @default.
- W2596178227 cites W2026071606 @default.
- W2596178227 cites W2026144205 @default.
- W2596178227 cites W2026514466 @default.
- W2596178227 cites W2026949272 @default.
- W2596178227 cites W2028712007 @default.
- W2596178227 cites W2028765929 @default.
- W2596178227 cites W2030549657 @default.
- W2596178227 cites W2031134755 @default.
- W2596178227 cites W2031363155 @default.
- W2596178227 cites W2031446306 @default.
- W2596178227 cites W2032413488 @default.
- W2596178227 cites W2037657244 @default.
- W2596178227 cites W2038976751 @default.
- W2596178227 cites W2039046531 @default.