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- W2596208416 abstract "For thousands of years humans have attempted to reduce complex phenomena—including thoughts, feelings, and behavior—to more simplistic, manageable explanations. Arguments have long existed about the relative importance of nature versus nurture—are a patient’s difficulties primarily the result of the genes he or she was born with or the impact of his or her early experiences? It is clear, at this point, that the answer is usually both: a complicated interplay of genes and environment that develops over time. Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and MiceBiological PsychiatryVol. 81Issue 8PreviewAdverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum. Full-Text PDF" @default.
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- W2596208416 date "2017-04-01" @default.
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- W2596208416 title "The Nature of Nurture: How Developmental Experiences Program Adult Stress Circuitry" @default.
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- W2596208416 doi "https://doi.org/10.1016/j.biopsych.2017.02.004" @default.
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