FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596227622> ?p ?o ?g. }

• W2596227622 endingPage "940" @default.
• W2596227622 startingPage "936" @default.
• W2596227622 abstract "Inflammatory bowel disease (IBD) is a refractory illness with remarkably increasing incidence rate all over the world. However, no desirable treatment scheme is available. Therefore, research and development of new drugs for treating IBD are urgently needed. Histone deacetylase 6 (HDAC6) is considered to be a pro-inflammatory factor, thus the inhibitors specifically-targeting HDAC6 may find their way in IBD treatment. In this study, we evaluated the anti-inflammatory activity of a novel potent and selective HDAC6 inhibitor, LTB2, in dextran sulfate sodium (DSS)-induced colitis mouse model. It was found that LTB2 treatment significantly alleviated DSS-induced colitis in mice, as evidenced by body weight, colon length, histological examination, and the disease activity index (DAI) scores of rectal bleeding and diarrhea. More importantly, it showed a better protective effect on the DSS-induced colitis mice than the commonly used mesalazine in the clinic. Our results demonstrated that selective HDAC6 inhibitors may have a good prospect for IBD treatment." @default.
• W2596227622 created "2017-03-23" @default.
• W2596227622 creator A5002092115 @default.
• W2596227622 creator A5010678518 @default.
• W2596227622 creator A5019279469 @default.
• W2596227622 creator A5023674368 @default.
• W2596227622 creator A5063089557 @default.
• W2596227622 date "2017-01-01" @default.
• W2596227622 modified "2023-10-02" @default.
• W2596227622 title "A Highly Potent and Selective Histone Deacetylase 6 Inhibitor Prevents DSS-Induced Colitis in Mice" @default.
• W2596227622 cites W1855226200 @default.
• W2596227622 cites W1910848366 @default.
• W2596227622 cites W1982283880 @default.
• W2596227622 cites W1997671473 @default.
• W2596227622 cites W2001507899 @default.
• W2596227622 cites W2005722172 @default.
• W2596227622 cites W2006588622 @default.
• W2596227622 cites W2028861852 @default.
• W2596227622 cites W2029148944 @default.
• W2596227622 cites W2047559139 @default.
• W2596227622 cites W2048547607 @default.
• W2596227622 cites W2050176313 @default.
• W2596227622 cites W2052368458 @default.
• W2596227622 cites W2063078660 @default.
• W2596227622 cites W2074558856 @default.
• W2596227622 cites W2076081852 @default.
• W2596227622 cites W2086718224 @default.
• W2596227622 cites W2088651611 @default.
• W2596227622 cites W2101663014 @default.
• W2596227622 cites W2102489631 @default.
• W2596227622 cites W2107733280 @default.
• W2596227622 cites W2109305602 @default.
• W2596227622 cites W2119133472 @default.
• W2596227622 cites W2123324115 @default.
• W2596227622 cites W2131455671 @default.
• W2596227622 cites W2141265087 @default.
• W2596227622 cites W2146955123 @default.
• W2596227622 cites W2147174530 @default.
• W2596227622 cites W2150267627 @default.
• W2596227622 cites W2162787110 @default.
• W2596227622 cites W2164893242 @default.
• W2596227622 cites W2182578492 @default.
• W2596227622 cites W2280342507 @default.
• W2596227622 cites W2400393709 @default.
• W2596227622 cites W2554912119 @default.
• W2596227622 doi "https://doi.org/10.1248/bpb.b16-01023" @default.
• W2596227622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28321036" @default.
• W2596227622 hasPublicationYear "2017" @default.
• W2596227622 type Work @default.
• W2596227622 sameAs 2596227622 @default.
• W2596227622 citedByCount "13" @default.
• W2596227622 countsByYear W25962276222018 @default.
• W2596227622 countsByYear W25962276222019 @default.
• W2596227622 countsByYear W25962276222020 @default.
• W2596227622 countsByYear W25962276222021 @default.
• W2596227622 countsByYear W25962276222022 @default.
• W2596227622 countsByYear W25962276222023 @default.
• W2596227622 crossrefType "journal-article" @default.
• W2596227622 hasAuthorship W2596227622A5002092115 @default.
• W2596227622 hasAuthorship W2596227622A5010678518 @default.
• W2596227622 hasAuthorship W2596227622A5019279469 @default.
• W2596227622 hasAuthorship W2596227622A5023674368 @default.
• W2596227622 hasAuthorship W2596227622A5063089557 @default.
• W2596227622 hasBestOaLocation W25962276221 @default.
• W2596227622 hasConcept C104317684 @default.
• W2596227622 hasConcept C126322002 @default.
• W2596227622 hasConcept C185592680 @default.
• W2596227622 hasConcept C203014093 @default.
• W2596227622 hasConcept C23681527 @default.
• W2596227622 hasConcept C2775862500 @default.
• W2596227622 hasConcept C2776202225 @default.
• W2596227622 hasConcept C2778260677 @default.
• W2596227622 hasConcept C2778305200 @default.
• W2596227622 hasConcept C2779134260 @default.
• W2596227622 hasConcept C2779174533 @default.
• W2596227622 hasConcept C2779802037 @default.
• W2596227622 hasConcept C55493867 @default.
• W2596227622 hasConcept C64927066 @default.
• W2596227622 hasConcept C71924100 @default.
• W2596227622 hasConcept C90924648 @default.
• W2596227622 hasConcept C98274493 @default.
• W2596227622 hasConceptScore W2596227622C104317684 @default.
• W2596227622 hasConceptScore W2596227622C126322002 @default.
• W2596227622 hasConceptScore W2596227622C185592680 @default.
• W2596227622 hasConceptScore W2596227622C203014093 @default.
• W2596227622 hasConceptScore W2596227622C23681527 @default.
• W2596227622 hasConceptScore W2596227622C2775862500 @default.
• W2596227622 hasConceptScore W2596227622C2776202225 @default.
• W2596227622 hasConceptScore W2596227622C2778260677 @default.
• W2596227622 hasConceptScore W2596227622C2778305200 @default.
• W2596227622 hasConceptScore W2596227622C2779134260 @default.
• W2596227622 hasConceptScore W2596227622C2779174533 @default.
• W2596227622 hasConceptScore W2596227622C2779802037 @default.
• W2596227622 hasConceptScore W2596227622C55493867 @default.
• W2596227622 hasConceptScore W2596227622C64927066 @default.
• W2596227622 hasConceptScore W2596227622C71924100 @default.
• W2596227622 hasConceptScore W2596227622C90924648 @default.
• W2596227622 hasConceptScore W2596227622C98274493 @default.

• next