Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596237462> ?p ?o ?g. }
- W2596237462 endingPage "60" @default.
- W2596237462 startingPage "646" @default.
- W2596237462 abstract "The heart of higher vertebrates is a structurally complicated multi-chambered pump that contracts synchronously. For its proper function a number of distinct integrated components have to be generated, including force-generating compartments, unidirectional valves, septa and a system in charge of the initiation and coordinated propagation of the depolarizing impulse over the heart. Not surprisingly, a large number of regulating factors are involved in these processes that act in complex and intertwined pathways to regulate the activity of target genes responsible for morphogenesis and function. The finding that mutations in T-box transcription factor-encoding genes in humans lead to congenital heart defects has focused attention on the importance of this family of regulators in heart development. Functional and genetic analyses in a variety of divergent species has demonstrated the critical roles of multiple T-box factor gene family members, including Tbx11, -2, -3, -5, -18 and -20, in the patterning, recruitment, specification, differentiation and growth processes underlying formation and integration of the heart components. Insight into the roles of T-box factors in these processes will enhance our understanding of heart formation and the underlying molecular regulatory pathways." @default.
- W2596237462 created "2017-03-23" @default.
- W2596237462 creator A5002005916 @default.
- W2596237462 creator A5004768958 @default.
- W2596237462 creator A5024997012 @default.
- W2596237462 creator A5073843586 @default.
- W2596237462 date "2007-03-01" @default.
- W2596237462 modified "2023-10-16" @default.
- W2596237462 title "T-box factors determine cardiac design." @default.
- W2596237462 cites W1501608538 @default.
- W2596237462 cites W1548932088 @default.
- W2596237462 cites W1602684793 @default.
- W2596237462 cites W1668449847 @default.
- W2596237462 cites W1768145300 @default.
- W2596237462 cites W1840001167 @default.
- W2596237462 cites W1955467086 @default.
- W2596237462 cites W1965159397 @default.
- W2596237462 cites W1966563415 @default.
- W2596237462 cites W1973431915 @default.
- W2596237462 cites W1974249466 @default.
- W2596237462 cites W1980110416 @default.
- W2596237462 cites W1982548006 @default.
- W2596237462 cites W1986820083 @default.
- W2596237462 cites W1988888035 @default.
- W2596237462 cites W1989003609 @default.
- W2596237462 cites W1989457690 @default.
- W2596237462 cites W1993827678 @default.
- W2596237462 cites W1994142299 @default.
- W2596237462 cites W1997808494 @default.
- W2596237462 cites W2000797432 @default.
- W2596237462 cites W2001277919 @default.
- W2596237462 cites W2002907359 @default.
- W2596237462 cites W2004454319 @default.
- W2596237462 cites W2010390017 @default.
- W2596237462 cites W2014193046 @default.
- W2596237462 cites W2016368778 @default.
- W2596237462 cites W2018078167 @default.
- W2596237462 cites W2018892038 @default.
- W2596237462 cites W2020126480 @default.
- W2596237462 cites W2022265743 @default.
- W2596237462 cites W2023081386 @default.
- W2596237462 cites W2036299862 @default.
- W2596237462 cites W2036768270 @default.
- W2596237462 cites W2040880342 @default.
- W2596237462 cites W2041399250 @default.
- W2596237462 cites W2045998016 @default.
- W2596237462 cites W2046026953 @default.
- W2596237462 cites W2047311303 @default.
- W2596237462 cites W2047838358 @default.
- W2596237462 cites W2050184933 @default.
- W2596237462 cites W2050880646 @default.
- W2596237462 cites W2053348556 @default.
- W2596237462 cites W2053503988 @default.
- W2596237462 cites W2054913890 @default.
- W2596237462 cites W2056546982 @default.
- W2596237462 cites W2060305085 @default.
- W2596237462 cites W2060418346 @default.
- W2596237462 cites W2062626279 @default.
- W2596237462 cites W2063177042 @default.
- W2596237462 cites W2066925075 @default.
- W2596237462 cites W2070175168 @default.
- W2596237462 cites W2073157874 @default.
- W2596237462 cites W2073615403 @default.
- W2596237462 cites W2074557542 @default.
- W2596237462 cites W2075401648 @default.
- W2596237462 cites W2076600697 @default.
- W2596237462 cites W2077103278 @default.
- W2596237462 cites W2078475439 @default.
- W2596237462 cites W2083248934 @default.
- W2596237462 cites W2084090304 @default.
- W2596237462 cites W2085221145 @default.
- W2596237462 cites W2085826645 @default.
- W2596237462 cites W2088906649 @default.
- W2596237462 cites W2094945602 @default.
- W2596237462 cites W2096751146 @default.
- W2596237462 cites W2096999174 @default.
- W2596237462 cites W2097836010 @default.
- W2596237462 cites W2099883675 @default.
- W2596237462 cites W2100633007 @default.
- W2596237462 cites W2102254218 @default.
- W2596237462 cites W2105985098 @default.
- W2596237462 cites W2108081173 @default.
- W2596237462 cites W2112991081 @default.
- W2596237462 cites W2114139217 @default.
- W2596237462 cites W2114919588 @default.
- W2596237462 cites W2115599237 @default.
- W2596237462 cites W2115606055 @default.
- W2596237462 cites W2115833670 @default.
- W2596237462 cites W2116419097 @default.
- W2596237462 cites W2121052817 @default.
- W2596237462 cites W2122457483 @default.
- W2596237462 cites W2124478777 @default.
- W2596237462 cites W2127387556 @default.
- W2596237462 cites W2129156306 @default.
- W2596237462 cites W2129389937 @default.
- W2596237462 cites W2130207795 @default.
- W2596237462 cites W2133607541 @default.
- W2596237462 cites W2137057749 @default.