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- W2596261485 startingPage "1" @default.
- W2596261485 abstract "Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate. This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and chemotherapy. Different epigenetic mechanisms such as histone modifications, DNA methylation, chromatin remodeling, and expression of noncoding RNAs drive the cell proliferation, invasion, metastasis, initiation, progression, and development of HCC. These epigenetic alterations because of potential reversibility open way towards the development of biomarkers and therapeutics. The contribution of these epigenetic changes to HCC development has not been thoroughly explored yet. Further research on HCC epigenetics is necessary to better understand novel molecular-targeted HCC treatment and prevention. This review highlights latest research progress and current updates regarding epigenetics of HCC, biomarker discovery, and future preventive and therapeutic strategies to combat the increasing risk of HCC." @default.
- W2596261485 created "2017-03-23" @default.
- W2596261485 creator A5004392631 @default.
- W2596261485 creator A5028663746 @default.
- W2596261485 creator A5070468083 @default.
- W2596261485 creator A5086078571 @default.
- W2596261485 date "2017-01-01" @default.
- W2596261485 modified "2023-09-30" @default.
- W2596261485 title "New Insights into the Epigenetics of Hepatocellular Carcinoma" @default.
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