Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596300099> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2596300099 endingPage "7083" @default.
- W2596300099 startingPage "7083" @default.
- W2596300099 abstract "7083 Background: Patients with Myelofibrosis (MF) suffer from significant fatigue, constitutional symptoms and splenomegaly (Mesa et. al. Cancer 2007) not improved by current therapy. The 6MWT measures functional status in cardio-pulmonary clinical trials. We undertook a prospective feasibility study of the 6MWT in MF patients for use in therapeutic clinical trials. Methods: MF patients (able to walk, normal vitals, not on a JAK2 inhibitor) were eligible. Baseline features and the MF symptom assessment form (MFSAF: Mesa et. al. Blood 2008) was administered. The 6MWT was administered in standardized fashion (American Thoracic Society: observed laps of a 30 - 35 meter long course, indoors, level, without encouragement), and then repeated for further validation. Results: Safety of the 6MWT: Fifty five MF patients were enrolled with only 2 patients (3%) stopping the 6MWT early secondary to fatigue. There were no adverse events attributable to undergoing the 6MWT in test subjects. Results of the 6MWT: Current results of our ongoing study demonstrate compared to age matched healthy volunteer controls, males with MF walk approximately 90 meters less and females with MF walk approximately 60 meters less (Table). Correlation of 6MWT Results to Patient Reported Symptoms (MFSAF): Results from the MFSAF demonstrated the fatigue (as assessed by the brief fatigue inventory (Medoza et. al. Cancer 1999) embedded in the MFSAF) showed patients with a higher BFI (i.e., more fatigued) had more impairment in the 6MWT than those with low BFI scores. Symptomatic burden as assessed by the MFSAF were typical for MF, correlation of individual symptom severity with 6MWT will require a larger trial for adequate power. Conclusions: The 6MWT can be safely performed in un-selected MF patients, and demonstrates a functional deficit compared to published controls. Validation of the ability of the 6MWT to measure functional improvements in MF patients as a response to novel therapy trials is planned. [Table: see text] No significant financial relationships to disclose." @default.
- W2596300099 created "2017-03-23" @default.
- W2596300099 creator A5016216479 @default.
- W2596300099 creator A5017875126 @default.
- W2596300099 creator A5024612499 @default.
- W2596300099 creator A5032370825 @default.
- W2596300099 creator A5038307470 @default.
- W2596300099 creator A5039057642 @default.
- W2596300099 creator A5055045706 @default.
- W2596300099 creator A5056358130 @default.
- W2596300099 creator A5077488440 @default.
- W2596300099 creator A5082890911 @default.
- W2596300099 creator A5089254242 @default.
- W2596300099 date "2009-05-20" @default.
- W2596300099 modified "2023-09-26" @default.
- W2596300099 title "Functional assessment of performance status in patients with myelofibrosis (MF): Utility and feasibility of the 6-minute walk test (6MWT)" @default.
- W2596300099 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.7083" @default.
- W2596300099 hasPublicationYear "2009" @default.
- W2596300099 type Work @default.
- W2596300099 sameAs 2596300099 @default.
- W2596300099 citedByCount "3" @default.
- W2596300099 countsByYear W25963000992012 @default.
- W2596300099 countsByYear W25963000992017 @default.
- W2596300099 countsByYear W25963000992019 @default.
- W2596300099 crossrefType "journal-article" @default.
- W2596300099 hasAuthorship W2596300099A5016216479 @default.
- W2596300099 hasAuthorship W2596300099A5017875126 @default.
- W2596300099 hasAuthorship W2596300099A5024612499 @default.
- W2596300099 hasAuthorship W2596300099A5032370825 @default.
- W2596300099 hasAuthorship W2596300099A5038307470 @default.
- W2596300099 hasAuthorship W2596300099A5039057642 @default.
- W2596300099 hasAuthorship W2596300099A5055045706 @default.
- W2596300099 hasAuthorship W2596300099A5056358130 @default.
- W2596300099 hasAuthorship W2596300099A5077488440 @default.
- W2596300099 hasAuthorship W2596300099A5082890911 @default.
- W2596300099 hasAuthorship W2596300099A5089254242 @default.
- W2596300099 hasConcept C126322002 @default.
- W2596300099 hasConcept C1862650 @default.
- W2596300099 hasConcept C188816634 @default.
- W2596300099 hasConcept C197934379 @default.
- W2596300099 hasConcept C2777753580 @default.
- W2596300099 hasConcept C2779134260 @default.
- W2596300099 hasConcept C2780007613 @default.
- W2596300099 hasConcept C2780076729 @default.
- W2596300099 hasConcept C535046627 @default.
- W2596300099 hasConcept C71924100 @default.
- W2596300099 hasConceptScore W2596300099C126322002 @default.
- W2596300099 hasConceptScore W2596300099C1862650 @default.
- W2596300099 hasConceptScore W2596300099C188816634 @default.
- W2596300099 hasConceptScore W2596300099C197934379 @default.
- W2596300099 hasConceptScore W2596300099C2777753580 @default.
- W2596300099 hasConceptScore W2596300099C2779134260 @default.
- W2596300099 hasConceptScore W2596300099C2780007613 @default.
- W2596300099 hasConceptScore W2596300099C2780076729 @default.
- W2596300099 hasConceptScore W2596300099C535046627 @default.
- W2596300099 hasConceptScore W2596300099C71924100 @default.
- W2596300099 hasIssue "15_suppl" @default.
- W2596300099 hasLocation W25963000991 @default.
- W2596300099 hasOpenAccess W2596300099 @default.
- W2596300099 hasPrimaryLocation W25963000991 @default.
- W2596300099 hasRelatedWork W2077076503 @default.
- W2596300099 hasRelatedWork W2257258247 @default.
- W2596300099 hasRelatedWork W2304558087 @default.
- W2596300099 hasRelatedWork W2810060832 @default.
- W2596300099 hasRelatedWork W2903749170 @default.
- W2596300099 hasRelatedWork W3001840506 @default.
- W2596300099 hasRelatedWork W4210709797 @default.
- W2596300099 hasRelatedWork W4224434039 @default.
- W2596300099 hasRelatedWork W4248511906 @default.
- W2596300099 hasRelatedWork W4312129460 @default.
- W2596300099 hasVolume "27" @default.
- W2596300099 isParatext "false" @default.
- W2596300099 isRetracted "false" @default.
- W2596300099 magId "2596300099" @default.
- W2596300099 workType "article" @default.