FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W25963204> ?p ?o ?g. }

• W25963204 endingPage "26" @default.
• W25963204 startingPage "217" @default.
• W25963204 abstract "We have evaluated the immunological abnormalities present in a 6 year old patient with primary intestinal and generalized lymphangiectasia confirmed by intestinal, lung and lymph node biopsies. Lymphocyte loss through the gut was confirmed by the detection of lymphocytes in her stool. An increased enteric protein loss was suggested by hypoproteinaemia, peripheral oedema, and a very short half-life for i.v. immune serum globulin (3 days). Lymphocyte subpopulation analysis revealed a selective loss of T lymphocytes, with a proportionally increased loss of the OKT4 positive helper/inducer subpopulation. Functionally, there was a decrease in proliferative responses to some mitogens and to allogeneic cells, and a lack of T cell help for in vitro B lymphocyte differentiation into immunoglobulin secreting cells. Natural killer function was normal. In this patient, a concomitant thymic deficiency was documented by failure to identify thymic tissue on a thymus biopsy and by an absence or decrease of the serum thymic factor (thymulin) and thymosin alpha 1. No compensatory lymphopoiesis was detected in the bone marrow. In an attempt to increase T lymphocyte development, the patient was treated with thymosin fraction 5. Daily treatment with this preparation resulted in a transient clinical improvement which could not be sustained on a weekly thymosin treatment schedule. However, lymphocyte numbers did not increase during this treatment. The findings in this patient support the notion that T lymphocytes are needed to stimulate thymic epithelium. In situations of excessive loss of long lived T lymphocytes a secondary thymic atrophy may occur and further contribute to the development of a deficiency in cell-mediated immunity." @default.
• W25963204 created "2016-06-24" @default.
• W25963204 creator A5020333390 @default.
• W25963204 creator A5022287195 @default.
• W25963204 creator A5024387362 @default.
• W25963204 creator A5025234530 @default.
• W25963204 creator A5042148345 @default.
• W25963204 creator A5054052790 @default.
• W25963204 creator A5068761013 @default.
• W25963204 date "1985-01-01" @default.
• W25963204 modified "2023-09-23" @default.
• W25963204 title "Intestinal lymphangiectasia and thymic hypoplasia." @default.
• W25963204 cites W145871740 @default.
• W25963204 cites W1550167335 @default.
• W25963204 cites W1627956077 @default.
• W25963204 cites W1804793262 @default.
• W25963204 cites W1965050022 @default.
• W25963204 cites W1993064155 @default.
• W25963204 cites W2001438510 @default.
• W25963204 cites W2015075399 @default.
• W25963204 cites W2020360024 @default.
• W25963204 cites W2035212228 @default.
• W25963204 cites W2035227976 @default.
• W25963204 cites W2037696837 @default.
• W25963204 cites W2043472897 @default.
• W25963204 cites W2057192805 @default.
• W25963204 cites W2061863401 @default.
• W25963204 cites W2076445404 @default.
• W25963204 cites W2082013662 @default.
• W25963204 cites W2169875375 @default.
• W25963204 cites W224752508 @default.
• W25963204 cites W2261805383 @default.
• W25963204 cites W2268293285 @default.
• W25963204 cites W2342123488 @default.
• W25963204 cites W2396700132 @default.
• W25963204 cites W2411541441 @default.
• W25963204 cites W2411555694 @default.
• W25963204 cites W2413547543 @default.
• W25963204 cites W2413869820 @default.
• W25963204 cites W2460513595 @default.
• W25963204 cites W1467621712 @default.
• W25963204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1577180" @default.
• W25963204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3971596" @default.
• W25963204 hasPublicationYear "1985" @default.
• W25963204 type Work @default.
• W25963204 sameAs 25963204 @default.
• W25963204 citedByCount "7" @default.
• W25963204 countsByYear W259632042021 @default.
• W25963204 crossrefType "journal-article" @default.
• W25963204 hasAuthorship W25963204A5020333390 @default.
• W25963204 hasAuthorship W25963204A5022287195 @default.
• W25963204 hasAuthorship W25963204A5024387362 @default.
• W25963204 hasAuthorship W25963204A5025234530 @default.
• W25963204 hasAuthorship W25963204A5042148345 @default.
• W25963204 hasAuthorship W25963204A5054052790 @default.
• W25963204 hasAuthorship W25963204A5068761013 @default.
• W25963204 hasConcept C109159458 @default.
• W25963204 hasConcept C126322002 @default.
• W25963204 hasConcept C134018914 @default.
• W25963204 hasConcept C159654299 @default.
• W25963204 hasConcept C181152851 @default.
• W25963204 hasConcept C203014093 @default.
• W25963204 hasConcept C2776451592 @default.
• W25963204 hasConcept C2777761686 @default.
• W25963204 hasConcept C2777805810 @default.
• W25963204 hasConcept C2778105408 @default.
• W25963204 hasConcept C2779615886 @default.
• W25963204 hasConcept C28328180 @default.
• W25963204 hasConcept C54355233 @default.
• W25963204 hasConcept C71924100 @default.
• W25963204 hasConcept C79904392 @default.
• W25963204 hasConcept C86803240 @default.
• W25963204 hasConcept C8891405 @default.
• W25963204 hasConceptScore W25963204C109159458 @default.
• W25963204 hasConceptScore W25963204C126322002 @default.
• W25963204 hasConceptScore W25963204C134018914 @default.
• W25963204 hasConceptScore W25963204C159654299 @default.
• W25963204 hasConceptScore W25963204C181152851 @default.
• W25963204 hasConceptScore W25963204C203014093 @default.
• W25963204 hasConceptScore W25963204C2776451592 @default.
• W25963204 hasConceptScore W25963204C2777761686 @default.
• W25963204 hasConceptScore W25963204C2777805810 @default.
• W25963204 hasConceptScore W25963204C2778105408 @default.
• W25963204 hasConceptScore W25963204C2779615886 @default.
• W25963204 hasConceptScore W25963204C28328180 @default.
• W25963204 hasConceptScore W25963204C54355233 @default.
• W25963204 hasConceptScore W25963204C71924100 @default.
• W25963204 hasConceptScore W25963204C79904392 @default.
• W25963204 hasConceptScore W25963204C86803240 @default.
• W25963204 hasConceptScore W25963204C8891405 @default.
• W25963204 hasIssue "1" @default.
• W25963204 hasLocation W259632041 @default.
• W25963204 hasOpenAccess W25963204 @default.
• W25963204 hasPrimaryLocation W259632041 @default.
• W25963204 hasRelatedWork W1430533758 @default.
• W25963204 hasRelatedWork W1981998182 @default.
• W25963204 hasRelatedWork W2022583443 @default.
• W25963204 hasRelatedWork W2032405347 @default.

• next