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- W2596399728 abstract "Abstract The nuclear factor I (NFI) family of transcription factors plays an important role in the development of the cerebral cortex in humans and mice. Disruption of nuclear factor IA (NFIA), nuclear factor IB (NFIB), or nuclear factor IX (NFIX) results in abnormal development of the corpus callosum, lateral ventricles, and hippocampus. However, the expression or function of these genes has not been examined in detail in the adult brain, and the cell type‐specific expression of NFIA, NFIB, and NFIX is currently unknown. Here, we demonstrate that the expression of each NFI protein shows a distinct laminar pattern in the adult mouse neocortex and that their cell type‐specific expression differs depending on the family member. NFIA expression was more frequently observed in astrocytes and oligodendroglia, whereas NFIB expression was predominantly localized to astrocytes and neurons. NFIX expression was most commonly observed in neurons. The NFI proteins were equally distributed within microglia, and the ependymal cells lining the ventricles of the brain expressed all three proteins. In the hippocampus, the NFI proteins were expressed during all stages of neural stem cell differentiation in the dentate gyrus, with higher expression intensity in neuroblast cells as compared to quiescent stem cells and mature granule neurons. These findings suggest that the NFI proteins may play distinct roles in cell lineage specification or maintenance, and establish the basis for further investigation of their function in the adult brain and their emerging role in disease." @default.
- W2596399728 created "2017-03-23" @default.
- W2596399728 creator A5024720316 @default.
- W2596399728 creator A5028690309 @default.
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- W2596399728 creator A5076967113 @default.
- W2596399728 creator A5086214764 @default.
- W2596399728 creator A5090328372 @default.
- W2596399728 date "2017-03-29" @default.
- W2596399728 modified "2023-10-17" @default.
- W2596399728 title "Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice" @default.
- W2596399728 cites W1501497312 @default.
- W2596399728 cites W155107415 @default.
- W2596399728 cites W1553965282 @default.
- W2596399728 cites W1834036377 @default.
- W2596399728 cites W1921704775 @default.
- W2596399728 cites W1963788090 @default.
- W2596399728 cites W1965921323 @default.
- W2596399728 cites W1967578054 @default.
- W2596399728 cites W1968759033 @default.
- W2596399728 cites W1971213127 @default.
- W2596399728 cites W1971912541 @default.
- W2596399728 cites W1974208182 @default.
- W2596399728 cites W1975972380 @default.
- W2596399728 cites W1978881816 @default.
- W2596399728 cites W1982105116 @default.
- W2596399728 cites W1996571763 @default.
- W2596399728 cites W2004773203 @default.
- W2596399728 cites W2007943561 @default.
- W2596399728 cites W2008713605 @default.
- W2596399728 cites W2009521014 @default.
- W2596399728 cites W2009999837 @default.
- W2596399728 cites W2013108229 @default.
- W2596399728 cites W2014888820 @default.
- W2596399728 cites W2015040450 @default.
- W2596399728 cites W2019231810 @default.
- W2596399728 cites W2021891225 @default.
- W2596399728 cites W2022722148 @default.
- W2596399728 cites W2029399940 @default.
- W2596399728 cites W2030800759 @default.
- W2596399728 cites W2032888368 @default.
- W2596399728 cites W2033273863 @default.
- W2596399728 cites W2036754144 @default.
- W2596399728 cites W2039452421 @default.
- W2596399728 cites W204348490 @default.
- W2596399728 cites W2044510301 @default.
- W2596399728 cites W2046095073 @default.
- W2596399728 cites W2046157151 @default.
- W2596399728 cites W2047678214 @default.
- W2596399728 cites W2048708798 @default.
- W2596399728 cites W2049087102 @default.
- W2596399728 cites W2051655214 @default.
- W2596399728 cites W2053176712 @default.
- W2596399728 cites W2054275187 @default.
- W2596399728 cites W2061293090 @default.
- W2596399728 cites W2062665585 @default.
- W2596399728 cites W2064741852 @default.
- W2596399728 cites W2088574511 @default.
- W2596399728 cites W2089394861 @default.
- W2596399728 cites W2089985797 @default.
- W2596399728 cites W2092041178 @default.
- W2596399728 cites W2095477656 @default.
- W2596399728 cites W2096500024 @default.
- W2596399728 cites W2097794137 @default.
- W2596399728 cites W2104141601 @default.
- W2596399728 cites W2105376114 @default.
- W2596399728 cites W2112282280 @default.
- W2596399728 cites W2114955073 @default.
- W2596399728 cites W2115155255 @default.
- W2596399728 cites W2117302968 @default.
- W2596399728 cites W2117344609 @default.
- W2596399728 cites W2119729549 @default.
- W2596399728 cites W2121399492 @default.
- W2596399728 cites W2121678464 @default.
- W2596399728 cites W2124940469 @default.
- W2596399728 cites W2128098926 @default.
- W2596399728 cites W2134112039 @default.
- W2596399728 cites W2137633946 @default.
- W2596399728 cites W2141351251 @default.
- W2596399728 cites W2141627956 @default.
- W2596399728 cites W2142932563 @default.
- W2596399728 cites W2150056436 @default.
- W2596399728 cites W2151381932 @default.
- W2596399728 cites W2153840519 @default.
- W2596399728 cites W2158496649 @default.
- W2596399728 cites W2158628437 @default.
- W2596399728 cites W2160799025 @default.
- W2596399728 cites W2163958669 @default.
- W2596399728 cites W2235944369 @default.
- W2596399728 cites W2290880820 @default.
- W2596399728 cites W2307322413 @default.
- W2596399728 cites W2326381346 @default.
- W2596399728 cites W2335791704 @default.
- W2596399728 cites W2341089549 @default.
- W2596399728 cites W921871570 @default.
- W2596399728 doi "https://doi.org/10.1002/cne.24206" @default.