FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596475650> ?p ?o ?g. }

• W2596475650 endingPage "389" @default.
• W2596475650 startingPage "378" @default.
• W2596475650 abstract "Tendon and ligament injuries are a persistent orthopedic challenge given their poor innate healing capacity. Nonwoven electrospun nanofibrous scaffolds composed of polyesters have been used to mimic the mechanics and topographical cues of native tendons and ligaments. However, nonwoven nanofibers have several limitations that prevent broader clinical application, including poor cell infiltration, as well as tensile and suture-retention strengths that are inferior to native tissues. In this study, multilayered scaffolds of aligned electrospun nanofibers of two designs–stacked or braided–were fabricated. Mechanical properties, including structural and mechanical properties and suture-retention strength, were determined using acellular scaffolds. Human bone marrow-derived mesenchymal stem cells (MSCs) were seeded on scaffolds for up to 28 days, and assays for tenogenic differentiation, histology, and biochemical composition were performed. Braided scaffolds exhibited improved tensile and suture-retention strengths, but reduced moduli. Both scaffold designs supported expression of tenogenic markers, although the effect was greater on braided scaffolds. Conversely, cell infiltration was superior in stacked constructs, resulting in enhanced cell number, total collagen content, and total sulfated glycosaminoglycan content. However, when normalized against cell number, both designs modulated extracellular matrix protein deposition to a similar degree. Taken together, this study demonstrates that multilayered scaffolds of aligned electrospun nanofibers supported tenogenic differentiation of seeded MSCs, but the macroarchitecture is an important consideration for applications of tendon and ligament tissue engineering." @default.
• W2596475650 created "2017-03-23" @default.
• W2596475650 creator A5039120856 @default.
• W2596475650 creator A5042070675 @default.
• W2596475650 creator A5054255291 @default.
• W2596475650 creator A5057499766 @default.
• W2596475650 creator A5058613373 @default.
• W2596475650 creator A5075821351 @default.
• W2596475650 date "2017-05-01" @default.
• W2596475650 modified "2023-10-16" @default.
• W2596475650 title "Braided and Stacked Electrospun Nanofibrous Scaffolds for Tendon and Ligament Tissue Engineering" @default.
• W2596475650 cites W1190271312 @default.
• W2596475650 cites W1446069030 @default.
• W2596475650 cites W1537102419 @default.
• W2596475650 cites W1586736369 @default.
• W2596475650 cites W1605158933 @default.
• W2596475650 cites W1696666441 @default.
• W2596475650 cites W1909152361 @default.
• W2596475650 cites W1916501302 @default.
• W2596475650 cites W1964313111 @default.
• W2596475650 cites W1964805122 @default.
• W2596475650 cites W1968580293 @default.
• W2596475650 cites W1972921941 @default.
• W2596475650 cites W1983595994 @default.
• W2596475650 cites W1984394011 @default.
• W2596475650 cites W1988846466 @default.
• W2596475650 cites W1990020414 @default.
• W2596475650 cites W1990851605 @default.
• W2596475650 cites W2002150738 @default.
• W2596475650 cites W2006808373 @default.
• W2596475650 cites W2007849025 @default.
• W2596475650 cites W2008029193 @default.
• W2596475650 cites W2012358527 @default.
• W2596475650 cites W2020280797 @default.
• W2596475650 cites W2020627692 @default.
• W2596475650 cites W2023190215 @default.
• W2596475650 cites W2029224784 @default.
• W2596475650 cites W2029661630 @default.
• W2596475650 cites W2030865793 @default.
• W2596475650 cites W2031098212 @default.
• W2596475650 cites W2036612479 @default.
• W2596475650 cites W2040336921 @default.
• W2596475650 cites W2043799833 @default.
• W2596475650 cites W2048750629 @default.
• W2596475650 cites W2052082578 @default.
• W2596475650 cites W2052744783 @default.
• W2596475650 cites W2055630021 @default.
• W2596475650 cites W2057896846 @default.
• W2596475650 cites W2062420045 @default.
• W2596475650 cites W2074416297 @default.
• W2596475650 cites W2080603184 @default.
• W2596475650 cites W2083875299 @default.
• W2596475650 cites W2089273131 @default.
• W2596475650 cites W2098003904 @default.
• W2596475650 cites W2100001398 @default.
• W2596475650 cites W2102981308 @default.
• W2596475650 cites W2105415546 @default.
• W2596475650 cites W2117890515 @default.
• W2596475650 cites W2118461131 @default.
• W2596475650 cites W2135466817 @default.
• W2596475650 cites W2141110565 @default.
• W2596475650 cites W2144776261 @default.
• W2596475650 cites W2153042507 @default.
• W2596475650 cites W2154864006 @default.
• W2596475650 cites W2156951480 @default.
• W2596475650 cites W2157929811 @default.
• W2596475650 cites W2160376341 @default.
• W2596475650 cites W2160539362 @default.
• W2596475650 cites W2166912059 @default.
• W2596475650 cites W2217037651 @default.
• W2596475650 cites W2284564527 @default.
• W2596475650 cites W2316423387 @default.
• W2596475650 cites W2415564049 @default.
• W2596475650 cites W610316706 @default.
• W2596475650 doi "https://doi.org/10.1089/ten.tea.2016.0319" @default.
• W2596475650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5444507" @default.
• W2596475650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28071988" @default.
• W2596475650 hasPublicationYear "2017" @default.
• W2596475650 type Work @default.
• W2596475650 sameAs 2596475650 @default.
• W2596475650 citedByCount "83" @default.
• W2596475650 countsByYear W25964756502017 @default.
• W2596475650 countsByYear W25964756502018 @default.
• W2596475650 countsByYear W25964756502019 @default.
• W2596475650 countsByYear W25964756502020 @default.
• W2596475650 countsByYear W25964756502021 @default.
• W2596475650 countsByYear W25964756502022 @default.
• W2596475650 countsByYear W25964756502023 @default.
• W2596475650 crossrefType "journal-article" @default.
• W2596475650 hasAuthorship W2596475650A5039120856 @default.
• W2596475650 hasAuthorship W2596475650A5042070675 @default.
• W2596475650 hasAuthorship W2596475650A5054255291 @default.
• W2596475650 hasAuthorship W2596475650A5057499766 @default.
• W2596475650 hasAuthorship W2596475650A5058613373 @default.
• W2596475650 hasAuthorship W2596475650A5075821351 @default.
• W2596475650 hasBestOaLocation W25964756502 @default.
• W2596475650 hasConcept C105702510 @default.
• W2596475650 hasConcept C112950240 @default.

• next