Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596558895> ?p ?o ?g. }
- W2596558895 endingPage "648" @default.
- W2596558895 startingPage "648" @default.
- W2596558895 abstract "The synthesis of two deoxygenated analogues of potent epothilones is reported in an effort to analyze the relative importance of molecular conformation and ligand–target interactions to biological activity. 7-deoxy-epothilone D and 7-deoxy-(S)-14-methoxy-epothilone D were prepared through total synthesis and shown to maintain the conformational preferences of their biologically active parent congeners through computer modeling and nuclear magnetic resonance (NMR) studies. The significant decrease in observed potency for each compound suggests that a hydrogen bond between the C7-hydroxyl group and the tubulin binding site plays a critical role in the energetics of binding in the epothilone class of polyketides." @default.
- W2596558895 created "2017-03-23" @default.
- W2596558895 creator A5009098444 @default.
- W2596558895 creator A5012789277 @default.
- W2596558895 creator A5025708608 @default.
- W2596558895 creator A5036657385 @default.
- W2596558895 creator A5087582978 @default.
- W2596558895 date "2017-03-17" @default.
- W2596558895 modified "2023-10-16" @default.
- W2596558895 title "Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues" @default.
- W2596558895 cites W1805944052 @default.
- W2596558895 cites W1958811049 @default.
- W2596558895 cites W1966307175 @default.
- W2596558895 cites W1970368199 @default.
- W2596558895 cites W1971579914 @default.
- W2596558895 cites W1972220601 @default.
- W2596558895 cites W1977360468 @default.
- W2596558895 cites W1980337077 @default.
- W2596558895 cites W1981224066 @default.
- W2596558895 cites W1982746572 @default.
- W2596558895 cites W1984050613 @default.
- W2596558895 cites W1985194484 @default.
- W2596558895 cites W1985607495 @default.
- W2596558895 cites W1985858069 @default.
- W2596558895 cites W1993577429 @default.
- W2596558895 cites W2005308681 @default.
- W2596558895 cites W2008336243 @default.
- W2596558895 cites W2013905807 @default.
- W2596558895 cites W2014587182 @default.
- W2596558895 cites W2014827824 @default.
- W2596558895 cites W2022412731 @default.
- W2596558895 cites W2025458379 @default.
- W2596558895 cites W2025589532 @default.
- W2596558895 cites W2028634057 @default.
- W2596558895 cites W2036601571 @default.
- W2596558895 cites W2039589572 @default.
- W2596558895 cites W2042100002 @default.
- W2596558895 cites W2048426133 @default.
- W2596558895 cites W2055785743 @default.
- W2596558895 cites W2059608328 @default.
- W2596558895 cites W2062582838 @default.
- W2596558895 cites W2085425240 @default.
- W2596558895 cites W2095871597 @default.
- W2596558895 cites W2107607807 @default.
- W2596558895 cites W2108035336 @default.
- W2596558895 cites W2140796459 @default.
- W2596558895 cites W2144087452 @default.
- W2596558895 cites W2151149788 @default.
- W2596558895 cites W2166343213 @default.
- W2596558895 cites W2314991324 @default.
- W2596558895 cites W2620176919 @default.
- W2596558895 cites W2950065526 @default.
- W2596558895 cites W4250956931 @default.
- W2596558895 doi "https://doi.org/10.3390/ijms18030648" @default.
- W2596558895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5372660" @default.
- W2596558895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28304361" @default.
- W2596558895 hasPublicationYear "2017" @default.
- W2596558895 type Work @default.
- W2596558895 sameAs 2596558895 @default.
- W2596558895 citedByCount "2" @default.
- W2596558895 countsByYear W25965588952018 @default.
- W2596558895 countsByYear W25965588952022 @default.
- W2596558895 crossrefType "journal-article" @default.
- W2596558895 hasAuthorship W2596558895A5009098444 @default.
- W2596558895 hasAuthorship W2596558895A5012789277 @default.
- W2596558895 hasAuthorship W2596558895A5025708608 @default.
- W2596558895 hasAuthorship W2596558895A5036657385 @default.
- W2596558895 hasAuthorship W2596558895A5087582978 @default.
- W2596558895 hasBestOaLocation W25965588951 @default.
- W2596558895 hasConcept C116073593 @default.
- W2596558895 hasConcept C116569031 @default.
- W2596558895 hasConcept C170493617 @default.
- W2596558895 hasConcept C178910836 @default.
- W2596558895 hasConcept C185592680 @default.
- W2596558895 hasConcept C202751555 @default.
- W2596558895 hasConcept C20418707 @default.
- W2596558895 hasConcept C2777526313 @default.
- W2596558895 hasConcept C2908737170 @default.
- W2596558895 hasConcept C55493867 @default.
- W2596558895 hasConcept C66974803 @default.
- W2596558895 hasConcept C71240020 @default.
- W2596558895 hasConcept C84425145 @default.
- W2596558895 hasConcept C86803240 @default.
- W2596558895 hasConcept C95444343 @default.
- W2596558895 hasConceptScore W2596558895C116073593 @default.
- W2596558895 hasConceptScore W2596558895C116569031 @default.
- W2596558895 hasConceptScore W2596558895C170493617 @default.
- W2596558895 hasConceptScore W2596558895C178910836 @default.
- W2596558895 hasConceptScore W2596558895C185592680 @default.
- W2596558895 hasConceptScore W2596558895C202751555 @default.
- W2596558895 hasConceptScore W2596558895C20418707 @default.
- W2596558895 hasConceptScore W2596558895C2777526313 @default.
- W2596558895 hasConceptScore W2596558895C2908737170 @default.
- W2596558895 hasConceptScore W2596558895C55493867 @default.
- W2596558895 hasConceptScore W2596558895C66974803 @default.
- W2596558895 hasConceptScore W2596558895C71240020 @default.
- W2596558895 hasConceptScore W2596558895C84425145 @default.
- W2596558895 hasConceptScore W2596558895C86803240 @default.