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- W2596576656 abstract "863 Background: Vinorelbine and mitoxantrone have both been demonstrated to have significant antitumor activity in patients with breast cancer. The aim of this study was to evaluate the efficacy and safety of the combination as second or third line treatment in patients with advanced breast cancer (ABC). Patients and Methods: Fifty-one previously treated patients with ABC were enrolled from October 2001 to May 2004 and 47 were eligible for treatment. Median age was 59 years (range 33–82) and ECOG performance status was <3. Distant sites of metastasis were as follows: liver 64%, bones 49%, lung 36%, lymph nodes 6%, skin 4%, brain 2% and other sites 6%. Locoregional lymph node metastasis was present in 17% of the patients. All patients received mitoxantrone 10mg/m2, D1 and vinorelbine 20mg/m2, D1+8 every 21 days for 6 cycles. A total of 204 cycles were delivered. The relative dose intensity of mitoxantrone and vinorelbine was 78% and 77%, respectively. Result: All eligible patients were analyzed for toxicit..." @default.
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- W2596576656 date "2005-06-01" @default.
- W2596576656 modified "2023-09-25" @default.
- W2596576656 title "Mitoxantrone plus vinorelbine in pretreated patients with advanced breast cancer" @default.
- W2596576656 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.863" @default.
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