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• W2596607430 endingPage "425" @default.
• W2596607430 startingPage "418" @default.
• W2596607430 abstract "The introduction of bariatric surgery into clinical practice in the 1980s was followed by a relatively long watch-and-wait period before the very rapid accumulation of scientific literature, over the past decade, concerning its clinical effectiveness and safety and its mechanisms of action in the treatment of obesity. These surgical procedures now emerge as the most effective therapeutic modality to induce long-term remission of type 2 diabetes. Recent research has shed light on the potential mechanisms leading to the profound improvement of glucose homeostasis following most bariatric surgery procedures. These mechanisms can be classified as weight loss dependent and independent, both playing sequential and then synergistic antidiabetes roles. Many groups, including our own, have contributed to our understanding of the relative roles of these mechanisms at differing time periods following these procedures. Here we summarize what we currently know about the mechanisms underlying the very rapid, weight loss-independent improvement in glucose homeostasis after bariatric surgery. Beyond its impact in the field of bariatric surgery, this new knowledge about the very rapid in vivo “reverse engineering” of type 2 diabetes actually provides unique insights into the intricate and complex mechanisms linking nutrition and obesity with the development of this disease." @default.
• W2596607430 created "2017-03-23" @default.
• W2596607430 creator A5014659365 @default.
• W2596607430 creator A5043659026 @default.
• W2596607430 creator A5049861022 @default.
• W2596607430 date "2017-08-01" @default.
• W2596607430 modified "2023-09-26" @default.
• W2596607430 title "Early Metabolic Improvement After Bariatric Surgery: The First Steps Toward Remission of Type 2 Diabetes" @default.
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