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- W2596620906 abstract "In the last few decades, a number of probabilistic modelsfor drug delivery have been developed. Of particularinterest are those that model controlled release systemsto provide targeted dose delivery. Controlled releaseis achieved by using polymers with dierent dissolutioncharacteristics. We present here a model basedon Monte Carlo and Cellular Automata approaches, forsimulating drug release from coated microspheres in thegastro-intestinal tract. Controlled release is obtained using ethylcellulose as the coating polymer. Modelling features, such as the drug and coating dissolution are nontrivial, since material is non-homogenously dispersedand the dissolution exhibits complex behaviour. Importantunderlying mechanisms of the process, such aserosion, are described here." @default.
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- W2596620906 date "2010-10-22" @default.
- W2596620906 modified "2023-09-24" @default.
- W2596620906 title "Probabilistic models for dissolution of ethylcellulose coated microspheres" @default.
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