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- W2596669968 abstract "Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR). Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR. Interestingly, while tianeptine also produces many opiate-like behavioral effects such as analgesia and reward, it does not lead to tolerance or withdrawal. Furthermore, the primary metabolite of tianeptine (MC5), which has a longer half-life, mimics the behavioral effects of tianeptine in a MOR-dependent fashion. These results point to the possibility that MOR and its downstream signaling cascades may be novel targets for antidepressant drug development." @default.
- W2596669968 created "2017-03-23" @default.
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- W2596669968 date "2017-03-17" @default.
- W2596669968 modified "2023-10-17" @default.
- W2596669968 title "The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor" @default.
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- W2596669968 doi "https://doi.org/10.1038/npp.2017.60" @default.
- W2596669968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5561344" @default.
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- W2596669968 hasPublicationYear "2017" @default.
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