Matches in SemOpenAlex for { <https://semopenalex.org/work/W25967098> ?p ?o ?g. }
- W25967098 endingPage "729" @default.
- W25967098 startingPage "723" @default.
- W25967098 abstract "A nuclear histone deacetylase from yeast was partially purified and some of its characteristics were studied. Histone deacetylase activity was stimulated in vitro by high-mobility-group nonhistone chromatin proteins 1 and 2 and ubiquitin and inhibited by spermine and spermidine, whereas n-butyrate had no significant inhibitory effect. Like the mammalian enzyme, partially purified histone deacetylase from yeast was strongly inhibited by trichostatin A. However, in crude extract preparations the yeast enzyme was not inhibited and treatment with trichostatin in vivo did not show any effect, either on the histone acetylation level or on cell viability. At low ionic strength, the enzyme can be isolated as a complex of high molecular mass that is much less inhibited by trichostatin A than is partially purified histone deacetylase activity. Furthermore, radiolabelled oligonucleosomes were more efficiently deacetylated by the complex than by the low-molecular-mass form of the enzyme. The histone deacetylase activity was separated from a polyamine deacetylase activity and its specificity studied. Using h.p.l.c.-purified core histone species as substrate, histone deacetylase from yeast is able to deacetylate all core histones with a slight preference for H3. Our results support the idea that the yeast histone deacetylase may act as a high-molecular-mass complex in vivo." @default.
- W25967098 created "2016-06-24" @default.
- W25967098 creator A5001801164 @default.
- W25967098 creator A5032556078 @default.
- W25967098 creator A5076207614 @default.
- W25967098 creator A5085886667 @default.
- W25967098 date "1994-11-01" @default.
- W25967098 modified "2023-10-03" @default.
- W25967098 title "Properties of the yeast nuclear histone deacetylase" @default.
- W25967098 cites W138633729 @default.
- W25967098 cites W1480703691 @default.
- W25967098 cites W1489315177 @default.
- W25967098 cites W1501349652 @default.
- W25967098 cites W1505269918 @default.
- W25967098 cites W1520738155 @default.
- W25967098 cites W1561209638 @default.
- W25967098 cites W1563624749 @default.
- W25967098 cites W1567042039 @default.
- W25967098 cites W1592806571 @default.
- W25967098 cites W1599990654 @default.
- W25967098 cites W1601888542 @default.
- W25967098 cites W1605878810 @default.
- W25967098 cites W1703243841 @default.
- W25967098 cites W1966792552 @default.
- W25967098 cites W1976025880 @default.
- W25967098 cites W1978504375 @default.
- W25967098 cites W1982486198 @default.
- W25967098 cites W1987524074 @default.
- W25967098 cites W1998006710 @default.
- W25967098 cites W2009155883 @default.
- W25967098 cites W2012161435 @default.
- W25967098 cites W2016761355 @default.
- W25967098 cites W2017525366 @default.
- W25967098 cites W2018663197 @default.
- W25967098 cites W2021734352 @default.
- W25967098 cites W2035492563 @default.
- W25967098 cites W2036965748 @default.
- W25967098 cites W2044118676 @default.
- W25967098 cites W2045527855 @default.
- W25967098 cites W2045765423 @default.
- W25967098 cites W2049366853 @default.
- W25967098 cites W2052259420 @default.
- W25967098 cites W2059902390 @default.
- W25967098 cites W2060135719 @default.
- W25967098 cites W2063798479 @default.
- W25967098 cites W2069179692 @default.
- W25967098 cites W2071364732 @default.
- W25967098 cites W2081333309 @default.
- W25967098 cites W2082944633 @default.
- W25967098 cites W2088256939 @default.
- W25967098 cites W2091980405 @default.
- W25967098 cites W2107270084 @default.
- W25967098 cites W2128240046 @default.
- W25967098 cites W2158382328 @default.
- W25967098 cites W2172212006 @default.
- W25967098 cites W2343852160 @default.
- W25967098 cites W69776591 @default.
- W25967098 doi "https://doi.org/10.1042/bj3030723" @default.
- W25967098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1137606" @default.
- W25967098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7980438" @default.
- W25967098 hasPublicationYear "1994" @default.
- W25967098 type Work @default.
- W25967098 sameAs 25967098 @default.
- W25967098 citedByCount "19" @default.
- W25967098 countsByYear W259670982015 @default.
- W25967098 countsByYear W259670982018 @default.
- W25967098 crossrefType "journal-article" @default.
- W25967098 hasAuthorship W25967098A5001801164 @default.
- W25967098 hasAuthorship W25967098A5032556078 @default.
- W25967098 hasAuthorship W25967098A5076207614 @default.
- W25967098 hasAuthorship W25967098A5085886667 @default.
- W25967098 hasBestOaLocation W259670982 @default.
- W25967098 hasConcept C142354902 @default.
- W25967098 hasConcept C153911025 @default.
- W25967098 hasConcept C185592680 @default.
- W25967098 hasConcept C27253355 @default.
- W25967098 hasConcept C2777865847 @default.
- W25967098 hasConcept C2778305200 @default.
- W25967098 hasConcept C4951695 @default.
- W25967098 hasConcept C552990157 @default.
- W25967098 hasConcept C55493867 @default.
- W25967098 hasConcept C64927066 @default.
- W25967098 hasConcept C71723506 @default.
- W25967098 hasConcept C86803240 @default.
- W25967098 hasConceptScore W25967098C142354902 @default.
- W25967098 hasConceptScore W25967098C153911025 @default.
- W25967098 hasConceptScore W25967098C185592680 @default.
- W25967098 hasConceptScore W25967098C27253355 @default.
- W25967098 hasConceptScore W25967098C2777865847 @default.
- W25967098 hasConceptScore W25967098C2778305200 @default.
- W25967098 hasConceptScore W25967098C4951695 @default.
- W25967098 hasConceptScore W25967098C552990157 @default.
- W25967098 hasConceptScore W25967098C55493867 @default.
- W25967098 hasConceptScore W25967098C64927066 @default.
- W25967098 hasConceptScore W25967098C71723506 @default.
- W25967098 hasConceptScore W25967098C86803240 @default.
- W25967098 hasIssue "3" @default.
- W25967098 hasLocation W259670981 @default.