FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596711208> ?p ?o ?g. }

• W2596711208 abstract "The ring finger protein PCGF6 (polycomb group ring finger 6) interacts with RING1A/B and E2F6 associated factors to form a non-canonical PRC1 (polycomb repressive complex 1) known as PCGF6-PRC1. Here, we demonstrate that PCGF6-PRC1 plays a role in repressing a subset of PRC1 target genes by recruiting RING1B and mediating downstream mono-ubiquitination of histone H2A. PCGF6-PRC1 bound loci are highly enriched for promoters of germ cell-related genes in mouse embryonic stem cells (ESCs). Conditional ablation of Pcgf6 in ESCs leads to robust de-repression of such germ cell-related genes, in turn affecting cell growth and viability. We also find a role for PCGF6 in pre- and peri-implantation mouse embryonic development. We further show that a heterodimer of the transcription factors MAX and MGA recruits PCGF6 to target loci. PCGF6 thus links sequence specific target recognition by the MAX/MGA complex to PRC1-dependent transcriptional silencing of germ cell-specific genes in pluripotent stem cells." @default.
• W2596711208 created "2017-03-23" @default.
• W2596711208 creator A5002573873 @default.
• W2596711208 creator A5006354960 @default.
• W2596711208 creator A5011658917 @default.
• W2596711208 creator A5015700472 @default.
• W2596711208 creator A5018219367 @default.
• W2596711208 creator A5018417608 @default.
• W2596711208 creator A5021594754 @default.
• W2596711208 creator A5022066306 @default.
• W2596711208 creator A5023962511 @default.
• W2596711208 creator A5048657878 @default.
• W2596711208 creator A5054636847 @default.
• W2596711208 creator A5060928906 @default.
• W2596711208 creator A5066057500 @default.
• W2596711208 creator A5072711950 @default.
• W2596711208 creator A5073071237 @default.
• W2596711208 creator A5075465763 @default.
• W2596711208 creator A5084355577 @default.
• W2596711208 creator A5087988071 @default.
• W2596711208 creator A5088383642 @default.
• W2596711208 date "2017-03-17" @default.
• W2596711208 modified "2023-10-09" @default.
• W2596711208 title "PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes" @default.
• W2596711208 cites W1571013355 @default.
• W2596711208 cites W1897886851 @default.
• W2596711208 cites W1975702835 @default.
• W2596711208 cites W1976963325 @default.
• W2596711208 cites W1996947994 @default.
• W2596711208 cites W2002915865 @default.
• W2596711208 cites W2009166526 @default.
• W2596711208 cites W2011753829 @default.
• W2596711208 cites W2012598468 @default.
• W2596711208 cites W2015132841 @default.
• W2596711208 cites W2018865924 @default.
• W2596711208 cites W2025553576 @default.
• W2596711208 cites W2028003321 @default.
• W2596711208 cites W2033162835 @default.
• W2596711208 cites W2033533217 @default.
• W2596711208 cites W2048916800 @default.
• W2596711208 cites W2060870400 @default.
• W2596711208 cites W2063687663 @default.
• W2596711208 cites W2068802700 @default.
• W2596711208 cites W2072466432 @default.
• W2596711208 cites W2075087486 @default.
• W2596711208 cites W2077561581 @default.
• W2596711208 cites W2084495183 @default.
• W2596711208 cites W2087172939 @default.
• W2596711208 cites W2093800333 @default.
• W2596711208 cites W2095111355 @default.
• W2596711208 cites W2118240383 @default.
• W2596711208 cites W2121437390 @default.
• W2596711208 cites W2122910069 @default.
• W2596711208 cites W2125037869 @default.
• W2596711208 cites W2126139450 @default.
• W2596711208 cites W2127455821 @default.
• W2596711208 cites W2143597290 @default.
• W2596711208 cites W2146497742 @default.
• W2596711208 cites W2148121673 @default.
• W2596711208 cites W2154284135 @default.
• W2596711208 cites W2157182132 @default.
• W2596711208 cites W2161604785 @default.
• W2596711208 cites W2162938913 @default.
• W2596711208 cites W2165894156 @default.
• W2596711208 cites W2167979016 @default.
• W2596711208 cites W2170079272 @default.
• W2596711208 cites W2171260083 @default.
• W2596711208 cites W2179299562 @default.
• W2596711208 cites W2312522248 @default.
• W2596711208 cites W2338782656 @default.
• W2596711208 cites W2412491965 @default.
• W2596711208 cites W2414116397 @default.
• W2596711208 cites W2419074032 @default.
• W2596711208 cites W2529260723 @default.
• W2596711208 cites W4236512674 @default.
• W2596711208 cites W2012767028 @default.
• W2596711208 doi "https://doi.org/10.7554/elife.21064" @default.
• W2596711208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5375644" @default.
• W2596711208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28304275" @default.
• W2596711208 hasPublicationYear "2017" @default.
• W2596711208 type Work @default.
• W2596711208 sameAs 2596711208 @default.
• W2596711208 citedByCount "88" @default.
• W2596711208 countsByYear W25967112082017 @default.
• W2596711208 countsByYear W25967112082018 @default.
• W2596711208 countsByYear W25967112082019 @default.
• W2596711208 countsByYear W25967112082020 @default.
• W2596711208 countsByYear W25967112082021 @default.
• W2596711208 countsByYear W25967112082022 @default.
• W2596711208 countsByYear W25967112082023 @default.
• W2596711208 crossrefType "journal-article" @default.
• W2596711208 hasAuthorship W2596711208A5002573873 @default.
• W2596711208 hasAuthorship W2596711208A5006354960 @default.
• W2596711208 hasAuthorship W2596711208A5011658917 @default.
• W2596711208 hasAuthorship W2596711208A5015700472 @default.
• W2596711208 hasAuthorship W2596711208A5018219367 @default.
• W2596711208 hasAuthorship W2596711208A5018417608 @default.
• W2596711208 hasAuthorship W2596711208A5021594754 @default.
• W2596711208 hasAuthorship W2596711208A5022066306 @default.
• W2596711208 hasAuthorship W2596711208A5023962511 @default.

• next