FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596733215> ?p ?o ?g. }

• W2596733215 endingPage "E333" @default.
• W2596733215 startingPage "E332" @default.
• W2596733215 abstract "Purpose/Objective(s)Malnutrition is a common problem for head and neck cancer patients. Loss of skeletal muscle mass, or sarcopenia, has been associated with malnutrition, poor tolerance of cancer therapy, and poorer outcomes in a number of malignancies. At our institution, we initiated a nutritional program where patients treated with definitive radiation therapy (RT) are evaluated and closely followed by a registered oncologic dietitian. In this report, we analyze nutritional factors and compliance with dietary recommendations for associations with overall survival (OS) and progression-free survival (PFS) in patients receiving definitive RT for laryngeal and oropharyngeal cancers.Materials/MethodsWe identified 352 patients with non-metastatic oropharyngeal (146) and laryngeal (206) cancer who were treated with definitive RT between 2004 and 2013. Disease and patient characteristics, treatment information, compliance with nutritional program, and clinical outcomes data were tabulated. Adherence to the nutritional program was scored weekly and patients were deemed non-compliant with nutritional program if they cancelled >25% of their appointments with the dietitian, refused nutritional counseling or did not follow recommendations. Of the 352 patients, 158 patients had a pretreatment CT including the abdomen within 30 days of RT start date to assess sarcopenia. Sarcopenia was defined based on muscle areas at the level of L3 using cutoffs established by Prado et al. Descriptive statistics, Kaplan Meier survival analysis, and log rank tests were performed, and Cox regression models were used to examine predictors of OS and PFS.ResultsThe median follow-up for the entire cohort was 22.86 (0.56-116) months. The actuarial rates for OS were 91%, 86% and 73% at years 1, 2, and 5, respectively. 70.9% (112/158) of patient with abdominal CT prior to starting RT were sarcopenic with a median muscle mass index of 48.2 (range: 30.4-70.9) for males and 35.9 (range: 24.6-53.2) for females. 85.8% (302/352) of patients met with a dietitian during their course of RT and 62.5% of patients who met with dietitian were compliant with the nutritional program. Compliance with the nutritional program resulted in 27% (HR: 0.73, 95% CI: 0.43, 1.26) and 31% (HR: 0.69, 95% CI: 0.50, 0.94) protection from death and disease progression. Lower pretreatment BMI was associated with a higher risk for death (HR: 0.94, 95%CI: 0.90, 0.99) and disease progression (HR: 0.96, 95% CI: 0.93, 0.99). Sarcopenia was not independently predictive for increased risk for overall death and disease progression.ConclusionLaryngeal and oropharyngeal cancer patients treated with definitive RT who are compliant with an aggressive nutritional program appear to have improved outcomes. Sarcopenia is very common in this patient population and further studies exploring ways to increase compliance with nutritional programs are warranted. Purpose/Objective(s)Malnutrition is a common problem for head and neck cancer patients. Loss of skeletal muscle mass, or sarcopenia, has been associated with malnutrition, poor tolerance of cancer therapy, and poorer outcomes in a number of malignancies. At our institution, we initiated a nutritional program where patients treated with definitive radiation therapy (RT) are evaluated and closely followed by a registered oncologic dietitian. In this report, we analyze nutritional factors and compliance with dietary recommendations for associations with overall survival (OS) and progression-free survival (PFS) in patients receiving definitive RT for laryngeal and oropharyngeal cancers. Malnutrition is a common problem for head and neck cancer patients. Loss of skeletal muscle mass, or sarcopenia, has been associated with malnutrition, poor tolerance of cancer therapy, and poorer outcomes in a number of malignancies. At our institution, we initiated a nutritional program where patients treated with definitive radiation therapy (RT) are evaluated and closely followed by a registered oncologic dietitian. In this report, we analyze nutritional factors and compliance with dietary recommendations for associations with overall survival (OS) and progression-free survival (PFS) in patients receiving definitive RT for laryngeal and oropharyngeal cancers. Materials/MethodsWe identified 352 patients with non-metastatic oropharyngeal (146) and laryngeal (206) cancer who were treated with definitive RT between 2004 and 2013. Disease and patient characteristics, treatment information, compliance with nutritional program, and clinical outcomes data were tabulated. Adherence to the nutritional program was scored weekly and patients were deemed non-compliant with nutritional program if they cancelled >25% of their appointments with the dietitian, refused nutritional counseling or did not follow recommendations. Of the 352 patients, 158 patients had a pretreatment CT including the abdomen within 30 days of RT start date to assess sarcopenia. Sarcopenia was defined based on muscle areas at the level of L3 using cutoffs established by Prado et al. Descriptive statistics, Kaplan Meier survival analysis, and log rank tests were performed, and Cox regression models were used to examine predictors of OS and PFS. We identified 352 patients with non-metastatic oropharyngeal (146) and laryngeal (206) cancer who were treated with definitive RT between 2004 and 2013. Disease and patient characteristics, treatment information, compliance with nutritional program, and clinical outcomes data were tabulated. Adherence to the nutritional program was scored weekly and patients were deemed non-compliant with nutritional program if they cancelled >25% of their appointments with the dietitian, refused nutritional counseling or did not follow recommendations. Of the 352 patients, 158 patients had a pretreatment CT including the abdomen within 30 days of RT start date to assess sarcopenia. Sarcopenia was defined based on muscle areas at the level of L3 using cutoffs established by Prado et al. Descriptive statistics, Kaplan Meier survival analysis, and log rank tests were performed, and Cox regression models were used to examine predictors of OS and PFS. ResultsThe median follow-up for the entire cohort was 22.86 (0.56-116) months. The actuarial rates for OS were 91%, 86% and 73% at years 1, 2, and 5, respectively. 70.9% (112/158) of patient with abdominal CT prior to starting RT were sarcopenic with a median muscle mass index of 48.2 (range: 30.4-70.9) for males and 35.9 (range: 24.6-53.2) for females. 85.8% (302/352) of patients met with a dietitian during their course of RT and 62.5% of patients who met with dietitian were compliant with the nutritional program. Compliance with the nutritional program resulted in 27% (HR: 0.73, 95% CI: 0.43, 1.26) and 31% (HR: 0.69, 95% CI: 0.50, 0.94) protection from death and disease progression. Lower pretreatment BMI was associated with a higher risk for death (HR: 0.94, 95%CI: 0.90, 0.99) and disease progression (HR: 0.96, 95% CI: 0.93, 0.99). Sarcopenia was not independently predictive for increased risk for overall death and disease progression. The median follow-up for the entire cohort was 22.86 (0.56-116) months. The actuarial rates for OS were 91%, 86% and 73% at years 1, 2, and 5, respectively. 70.9% (112/158) of patient with abdominal CT prior to starting RT were sarcopenic with a median muscle mass index of 48.2 (range: 30.4-70.9) for males and 35.9 (range: 24.6-53.2) for females. 85.8% (302/352) of patients met with a dietitian during their course of RT and 62.5% of patients who met with dietitian were compliant with the nutritional program. Compliance with the nutritional program resulted in 27% (HR: 0.73, 95% CI: 0.43, 1.26) and 31% (HR: 0.69, 95% CI: 0.50, 0.94) protection from death and disease progression. Lower pretreatment BMI was associated with a higher risk for death (HR: 0.94, 95%CI: 0.90, 0.99) and disease progression (HR: 0.96, 95% CI: 0.93, 0.99). Sarcopenia was not independently predictive for increased risk for overall death and disease progression. ConclusionLaryngeal and oropharyngeal cancer patients treated with definitive RT who are compliant with an aggressive nutritional program appear to have improved outcomes. Sarcopenia is very common in this patient population and further studies exploring ways to increase compliance with nutritional programs are warranted. Laryngeal and oropharyngeal cancer patients treated with definitive RT who are compliant with an aggressive nutritional program appear to have improved outcomes. Sarcopenia is very common in this patient population and further studies exploring ways to increase compliance with nutritional programs are warranted." @default.
• W2596733215 created "2017-03-23" @default.
• W2596733215 creator A5001361169 @default.
• W2596733215 creator A5006672154 @default.
• W2596733215 creator A5010037295 @default.
• W2596733215 creator A5012613982 @default.
• W2596733215 creator A5033564940 @default.
• W2596733215 creator A5039303398 @default.
• W2596733215 creator A5043898607 @default.
• W2596733215 creator A5045385836 @default.
• W2596733215 creator A5047234096 @default.
• W2596733215 creator A5054172281 @default.
• W2596733215 creator A5055510159 @default.
• W2596733215 creator A5056657513 @default.
• W2596733215 creator A5056971744 @default.
• W2596733215 creator A5073730409 @default.
• W2596733215 creator A5075702962 @default.
• W2596733215 creator A5084119820 @default.
• W2596733215 creator A5087238419 @default.
• W2596733215 creator A5087939653 @default.
• W2596733215 creator A5090586786 @default.
• W2596733215 creator A5091845742 @default.
• W2596733215 date "2015-11-01" @default.
• W2596733215 modified "2023-09-30" @default.
• W2596733215 title "The Impact of Dietary Regimen Compliance and Sarcopenia in Head and Neck Cancer Patients Treated With Definitive Radiation Therapy" @default.
• W2596733215 doi "https://doi.org/10.1016/j.ijrobp.2015.07.1395" @default.
• W2596733215 hasPublicationYear "2015" @default.
• W2596733215 type Work @default.
• W2596733215 sameAs 2596733215 @default.
• W2596733215 citedByCount "3" @default.
• W2596733215 countsByYear W25967332152019 @default.
• W2596733215 countsByYear W25967332152020 @default.
• W2596733215 crossrefType "journal-article" @default.
• W2596733215 hasAuthorship W2596733215A5001361169 @default.
• W2596733215 hasAuthorship W2596733215A5006672154 @default.
• W2596733215 hasAuthorship W2596733215A5010037295 @default.
• W2596733215 hasAuthorship W2596733215A5012613982 @default.
• W2596733215 hasAuthorship W2596733215A5033564940 @default.
• W2596733215 hasAuthorship W2596733215A5039303398 @default.
• W2596733215 hasAuthorship W2596733215A5043898607 @default.
• W2596733215 hasAuthorship W2596733215A5045385836 @default.
• W2596733215 hasAuthorship W2596733215A5047234096 @default.
• W2596733215 hasAuthorship W2596733215A5054172281 @default.
• W2596733215 hasAuthorship W2596733215A5055510159 @default.
• W2596733215 hasAuthorship W2596733215A5056657513 @default.
• W2596733215 hasAuthorship W2596733215A5056971744 @default.
• W2596733215 hasAuthorship W2596733215A5073730409 @default.
• W2596733215 hasAuthorship W2596733215A5075702962 @default.
• W2596733215 hasAuthorship W2596733215A5084119820 @default.
• W2596733215 hasAuthorship W2596733215A5087238419 @default.
• W2596733215 hasAuthorship W2596733215A5087939653 @default.
• W2596733215 hasAuthorship W2596733215A5090586786 @default.
• W2596733215 hasAuthorship W2596733215A5091845742 @default.
• W2596733215 hasConcept C126322002 @default.
• W2596733215 hasConcept C141071460 @default.
• W2596733215 hasConcept C143998085 @default.
• W2596733215 hasConcept C15744967 @default.
• W2596733215 hasConcept C1862650 @default.
• W2596733215 hasConcept C2776214593 @default.
• W2596733215 hasConcept C2776530083 @default.
• W2596733215 hasConcept C2781413609 @default.
• W2596733215 hasConcept C2781460075 @default.
• W2596733215 hasConcept C3018411727 @default.
• W2596733215 hasConcept C509974204 @default.
• W2596733215 hasConcept C71924100 @default.
• W2596733215 hasConcept C77805123 @default.
• W2596733215 hasConceptScore W2596733215C126322002 @default.
• W2596733215 hasConceptScore W2596733215C141071460 @default.
• W2596733215 hasConceptScore W2596733215C143998085 @default.
• W2596733215 hasConceptScore W2596733215C15744967 @default.
• W2596733215 hasConceptScore W2596733215C1862650 @default.
• W2596733215 hasConceptScore W2596733215C2776214593 @default.
• W2596733215 hasConceptScore W2596733215C2776530083 @default.
• W2596733215 hasConceptScore W2596733215C2781413609 @default.
• W2596733215 hasConceptScore W2596733215C2781460075 @default.
• W2596733215 hasConceptScore W2596733215C3018411727 @default.
• W2596733215 hasConceptScore W2596733215C509974204 @default.
• W2596733215 hasConceptScore W2596733215C71924100 @default.
• W2596733215 hasConceptScore W2596733215C77805123 @default.
• W2596733215 hasIssue "3" @default.
• W2596733215 hasLocation W25967332151 @default.
• W2596733215 hasOpenAccess W2596733215 @default.
• W2596733215 hasPrimaryLocation W25967332151 @default.
• W2596733215 hasRelatedWork W1993267564 @default.
• W2596733215 hasRelatedWork W2007176132 @default.
• W2596733215 hasRelatedWork W2092390197 @default.
• W2596733215 hasRelatedWork W2318228201 @default.
• W2596733215 hasRelatedWork W2410190481 @default.
• W2596733215 hasRelatedWork W2529376761 @default.
• W2596733215 hasRelatedWork W2539438258 @default.
• W2596733215 hasRelatedWork W2601224035 @default.
• W2596733215 hasRelatedWork W3133449565 @default.
• W2596733215 hasRelatedWork W2782093815 @default.
• W2596733215 hasVolume "93" @default.
• W2596733215 isParatext "false" @default.
• W2596733215 isRetracted "false" @default.
• W2596733215 magId "2596733215" @default.
• W2596733215 workType "article" @default.