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- W2596753368 abstract "The aim of the study was to purify and characterize a bioactive compound from Aspergillus nidulans strain KZR‐132 and its biological evaluation. A bioactive extolite was purified from A. nidulans strain KZR‐132, and its chemical structure was elucidated as 3‐hydroxylbenzyl alcohol (3‐HBA) based on 1H and 13C NMR, FT‐IR and mass spectroscopic analysis. The antimicrobial efficacy of 3‐HBA was established against Gram‐positive, Gram‐negative bacteria and different Candida strains. It also showed promising antibiofilm activity against various tested microbial strains. Reactive oxygen species induced by 3‐HBA treatment on different Candida strains killed most of the cells and showed necrotic effect. It also exhibited dose‐dependent antioxidant and anti‐inflammatory activities. This bioactive extrolite produced by A. nidulans isolated from a niche habitat was demonstrated to possess significant biotechnological and pharmacological potential since it exhibited broad‐spectrum antimicrobial and antibiofilm activities which are reported for the first time. The overall study demonstrates that 3‐HBA produced by A. nidulansKZR‐132 is a promising bioactive metabolite and possibly can function as a pharmacologically suitable broad‐spectrum antimicrobial drug candidate against various dreaded human‐related bacterial and fungal pathogens." @default.
- W2596753368 created "2017-03-23" @default.
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- W2596753368 date "2017-05-08" @default.
- W2596753368 modified "2023-09-26" @default.
- W2596753368 title "Biological evaluation of 3-hydroxybenzyl alcohol, an extrolite produced by<i>Aspergillus nidulans</i>strain KZR-132" @default.
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- W2596753368 doi "https://doi.org/10.1111/jam.13450" @default.
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