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- W2596817102 abstract "Topical drug delivery systems of Fluconazole, antifungal drug in the form of gels were formulated using polymers like HPMC, Carbopol 934, Methylcellulose and Sodium alginate. The gels were evaluated for various physicochemical parameters like pH, viscosity, rheology, drug content , spreadibilit y and skin irritation test. In addition, in vitro drug release by diffusion using cellophane membrane and permeation through hairless rat skin using modified Kiesery Chien Diffusion cell was performed. The rheological behaviour and apparent viscosity values for different gel bases were measured before and after storage under freezing condition at 2-8 0C and were taken as measure for stability of gel network structure. Also accelerated stability testing at 45±2 0C and 75%±5% R.H for 3 months were performed. Among the four formulat ions, gel prepared using HPMC shows desired propert ies and exhibit bet ter release pat tern when compared with other formulations prepared with Carbopol, Sodium alginate and Methylcellulose" @default.
- W2596817102 created "2017-03-23" @default.
- W2596817102 creator A5011423268 @default.
- W2596817102 date "2016-09-09" @default.
- W2596817102 modified "2023-09-25" @default.
- W2596817102 title "FORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASESFORMULATION DEVELOPMENT AND EVALUATION OF FLUCONAZOLE GEL IN VARIOUS POLYMER BASES" @default.
- W2596817102 doi "https://doi.org/10.22377/ajp.v1i1.742" @default.
- W2596817102 hasPublicationYear "2016" @default.
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