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- W2596865872 abstract "Low concentrations of hydroxyurea stimulated the growth of the blue-greeu alga Anabaena variabilis while high concentrations inhibited it. Treatment of cells with hydroxyurea resulted in a steep decline in the number of survivors during the first few minutes of treatment and this was followed by slower killing during further continued exposure. Administration of additional doses of hydroxyurea at different points along the growth curve produced in general an inhibitory effect on growth. The inhibition was stronger when the drug was added during or soon after lag-phase and it decreased with increase in the age of the culture up to the eighth day, after which there was no perceptible effect. A study of the relationship between age of inoculum and its lag in hydroxyurea medium revealed that exponentially growing cells showed least lag whereas cells in the lag phase or the stationary phase of growth grew after long lags. No adaptation to hydroxyurea concentrations higher than those tolerated by untreated alga occurred during the course of ten successive subcultures in media containing hydroxyurea." @default.
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- W2596865872 date "1968-01-01" @default.
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- W2596865872 title "Action of hydroxyurea on the blue-green alga Anabaena variabilis" @default.
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- W2596865872 doi "https://doi.org/10.1016/s0367-1836(17)30140-4" @default.
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