Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596906325> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2596906325 abstract "Rivaroxaban is an oral direct factor Xa inhibitor approved for the treatment of stroke and systemic thromboembolism in patients with non-valvular atrial fibrillation. Despite its efficacy, rivaroxaban therapy results in adverse effects and complications, such as bleeding. Angiotensin II (AngII) is implicated in many cardiovascular conditions, such as hypertension and heart failure. In this study, we investigate whether AngII influences anticoagulant effects of rivaroxaban by using an experimental mouse model with type 2 diabetes mellitus and advanced glycation end product (AGE)-exposed human umbilical vein endothelial cells (HUVECs). We found that AngII promoted the anticoagulant effects of rivaroxaban in KKAy mice. The combination of rivaroxaban and AngII enhanced in vivo tissue factor pathway inhibitor (TFPI) activity and induced TFPI expression and activity in AGE-exposed HUVECs. Angiotensin type 2 receptor (AT2R) and Mas antagonists attenuated the AngII-enhanced anticoagulant action of rivaroxaban in vivo, and abolished the increased endothelial TFPI expression and activity. However, angiotensin type 1 receptor (AT1R) antagonist exerted no effects. Additionally, combination of rivaroxaban and AngII induced aortic AT2R and Mas expression. Our data suggest that the anticoagulant effects of rivaroxaban are promoted by AngII via AT2R and Mas signaling. These findings are significant for the clinical administration of rivaroxaban." @default.
- W2596906325 created "2017-03-23" @default.
- W2596906325 creator A5014283519 @default.
- W2596906325 creator A5031528894 @default.
- W2596906325 creator A5037736384 @default.
- W2596906325 creator A5041167986 @default.
- W2596906325 creator A5050976890 @default.
- W2596906325 creator A5069464227 @default.
- W2596906325 date "2017-03-23" @default.
- W2596906325 modified "2023-10-05" @default.
- W2596906325 title "Angiotensin II promotes the anticoagulant effects of rivaroxaban via angiotensin type 2 receptor signaling in mice" @default.
- W2596906325 cites W195015772 @default.
- W2596906325 cites W1966442328 @default.
- W2596906325 cites W1980434555 @default.
- W2596906325 cites W1990048254 @default.
- W2596906325 cites W2000893896 @default.
- W2596906325 cites W2004380446 @default.
- W2596906325 cites W2007196951 @default.
- W2596906325 cites W2012833122 @default.
- W2596906325 cites W2018882645 @default.
- W2596906325 cites W2024142697 @default.
- W2596906325 cites W2046448349 @default.
- W2596906325 cites W2074232276 @default.
- W2596906325 cites W2115060813 @default.
- W2596906325 cites W2117714031 @default.
- W2596906325 cites W2125729240 @default.
- W2596906325 cites W2150986083 @default.
- W2596906325 cites W2158974240 @default.
- W2596906325 cites W2167553377 @default.
- W2596906325 cites W2209280676 @default.
- W2596906325 doi "https://doi.org/10.1038/s41598-017-00473-5" @default.
- W2596906325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5428434" @default.
- W2596906325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28337024" @default.
- W2596906325 hasPublicationYear "2017" @default.
- W2596906325 type Work @default.
- W2596906325 sameAs 2596906325 @default.
- W2596906325 citedByCount "7" @default.
- W2596906325 countsByYear W25969063252017 @default.
- W2596906325 countsByYear W25969063252018 @default.
- W2596906325 countsByYear W25969063252021 @default.
- W2596906325 countsByYear W25969063252023 @default.
- W2596906325 crossrefType "journal-article" @default.
- W2596906325 hasAuthorship W2596906325A5014283519 @default.
- W2596906325 hasAuthorship W2596906325A5031528894 @default.
- W2596906325 hasAuthorship W2596906325A5037736384 @default.
- W2596906325 hasAuthorship W2596906325A5041167986 @default.
- W2596906325 hasAuthorship W2596906325A5050976890 @default.
- W2596906325 hasAuthorship W2596906325A5069464227 @default.
- W2596906325 hasBestOaLocation W25969063251 @default.
- W2596906325 hasConcept C104849204 @default.
- W2596906325 hasConcept C126322002 @default.
- W2596906325 hasConcept C170493617 @default.
- W2596906325 hasConcept C186738567 @default.
- W2596906325 hasConcept C2776301958 @default.
- W2596906325 hasConcept C2777151630 @default.
- W2596906325 hasConcept C2778205648 @default.
- W2596906325 hasConcept C2778382381 @default.
- W2596906325 hasConcept C2778661090 @default.
- W2596906325 hasConcept C2779161974 @default.
- W2596906325 hasConcept C2780288358 @default.
- W2596906325 hasConcept C2908929049 @default.
- W2596906325 hasConcept C71924100 @default.
- W2596906325 hasConcept C98274493 @default.
- W2596906325 hasConceptScore W2596906325C104849204 @default.
- W2596906325 hasConceptScore W2596906325C126322002 @default.
- W2596906325 hasConceptScore W2596906325C170493617 @default.
- W2596906325 hasConceptScore W2596906325C186738567 @default.
- W2596906325 hasConceptScore W2596906325C2776301958 @default.
- W2596906325 hasConceptScore W2596906325C2777151630 @default.
- W2596906325 hasConceptScore W2596906325C2778205648 @default.
- W2596906325 hasConceptScore W2596906325C2778382381 @default.
- W2596906325 hasConceptScore W2596906325C2778661090 @default.
- W2596906325 hasConceptScore W2596906325C2779161974 @default.
- W2596906325 hasConceptScore W2596906325C2780288358 @default.
- W2596906325 hasConceptScore W2596906325C2908929049 @default.
- W2596906325 hasConceptScore W2596906325C71924100 @default.
- W2596906325 hasConceptScore W2596906325C98274493 @default.
- W2596906325 hasIssue "1" @default.
- W2596906325 hasLocation W25969063251 @default.
- W2596906325 hasLocation W25969063252 @default.
- W2596906325 hasLocation W25969063253 @default.
- W2596906325 hasLocation W25969063254 @default.
- W2596906325 hasLocation W25969063255 @default.
- W2596906325 hasOpenAccess W2596906325 @default.
- W2596906325 hasPrimaryLocation W25969063251 @default.
- W2596906325 hasRelatedWork W1991157605 @default.
- W2596906325 hasRelatedWork W1992363959 @default.
- W2596906325 hasRelatedWork W2011676580 @default.
- W2596906325 hasRelatedWork W2048260508 @default.
- W2596906325 hasRelatedWork W2090731568 @default.
- W2596906325 hasRelatedWork W2116796027 @default.
- W2596906325 hasRelatedWork W2296792352 @default.
- W2596906325 hasRelatedWork W2321919270 @default.
- W2596906325 hasRelatedWork W2404517290 @default.
- W2596906325 hasRelatedWork W2418445678 @default.
- W2596906325 hasVolume "7" @default.
- W2596906325 isParatext "false" @default.
- W2596906325 isRetracted "false" @default.
- W2596906325 magId "2596906325" @default.
- W2596906325 workType "article" @default.