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- W2596906932 abstract "Chronic alcohol consumption is now recognized as a factor that enhancessusceptibility to cardiovascular diseases through mechanisms that still are not completely cleared. Thepurpose of the present study was to investigate the effect of ginger extract on 8-hydroxy-2' -deoxyguanosine (8-OHdG) changes and as well as heart muscle cell proliferation induced by ethanol inthe heart of rat.Materials & Methods: Twenty-four male Wistar rats were regimented to three equal sized groups: 1.Control, 2. ethanol (4.5 gr/kg BW by gavaj), 3. Ginger extract treated ethanolic groups (4.5 gr/kg ethanolalong 50 mg of ginger extract). After 42 days, 8-OHdG and cell proliferation in heart tissue weremeasured.Results: The results showed a significant increasing in 8-OHdG amounts and heart muscle cellproliferation in ethanol group compared to the control group. Ginger extract administration alongethanol, reduced significantly 8-OHdG amounts and heart muscle cell proliferation compared to theethanol group.Conclusion: These findings indicate that ginger extract significantly improves heart structuralabnormality in ethanolic rats and that these effects can be associated with antioxidant and antiinflammatory properties of ginger extract." @default.
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- W2596906932 date "2016-03-15" @default.
- W2596906932 modified "2023-09-24" @default.
- W2596906932 title "EVALUATION THE EFFECT OF GINGER HYDRO-ALCOHOLIC EXTRACT ON THE HEART DYSFUNCTIONS INDUCED BY ALCHOHOL IN RAT" @default.
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