FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596950809> ?p ?o ?g. }

• W2596950809 abstract "10522 Background: BRM is a key subunit of the chromatin remodeling complex SWI/SNF and a putative tumor suppressor gene that is silenced in 15-20% of many solid tumors (PMID 15722796). Evidence suggests that it is epigenetically regulated, as two BRM promoter insertion variants (BRM-741 and BRM-1321) may lead to gene silencing by recruiting histone deacetylases. The presence of both homozygous BRM-741 and BRM-1321 highly correlate with loss of BRM expression and function in lung tumors, while increasing smoking-related lung cancer by two-fold (PMID 21478907). Also, the pharmacologic reversal of epigenetic changes of BRM offers a potential novel therapeutic approach (PMID 21478905). We assessed whether these BRM variants are associated with the risk of upper aerodigestive tract cancers, focusing on Stage I/II tumors that would most benefit from new screening and prevention strategies. Methods: BRM was genotyped by qPCR using TaqMan probes. 1,008 controls were matched to 595 cases by frequency distribution based on age, gender and smoking status. Multivariate logistic regression generated adjusted odds ratios (aOR). Results: The 595 cases were: 115 esophageal, 278 lung, and 202 head and neck cancers. 51% were adenocarcinomas; 60% were Stage I. The frequency of homozygozity was: BRM-741, 26%; BRM-1321, 23%; both variants, 15%. In the combined analysis, there was significant correlation between malignancy and homozygous BRM-741 (aOR 1.91 (95%CI 1.3-2.4); p=0.001) or BRM-1321 (aOR 1.94 (95%CI 1.4-2.7; p=3x10E-4). Being homozygous for both BRM variants carried an even greater risk (aOR 2.45 (95%CI 1.6-3.9); p=1x10E-5). This correlation was similar for adenocarcinomas (aOR 2.53 (95%CI 1.4-4.2); p=6x10E-4) and squamous cell carcinomas (aOR 2.33 (95%CI 1.3-4.4); p=8x10E-4). The increased cancer risk was also similar between these subgroups: head and neck, esophageal and lung cancers; Stage I and II patients; smokers and non-smokers. Conclusions: The two homozygous BRM variants increase the risk of early stage upper aerodigestive tumors by more than two-fold independent of smoking status. BRM promoter variants and their potential epigenetic effect may be early events in the evolution of these cancers." @default.
• W2596950809 created "2017-03-23" @default.
• W2596950809 creator A5012748795 @default.
• W2596950809 creator A5017825677 @default.
• W2596950809 creator A5023531951 @default.
• W2596950809 creator A5027583508 @default.
• W2596950809 creator A5031847465 @default.
• W2596950809 creator A5034148230 @default.
• W2596950809 creator A5037245212 @default.
• W2596950809 creator A5043131704 @default.
• W2596950809 creator A5050035970 @default.
• W2596950809 creator A5055325118 @default.
• W2596950809 creator A5056959902 @default.
• W2596950809 creator A5066370108 @default.
• W2596950809 creator A5067008822 @default.
• W2596950809 creator A5068644454 @default.
• W2596950809 creator A5075347427 @default.
• W2596950809 creator A5075467430 @default.
• W2596950809 creator A5077514596 @default.
• W2596950809 creator A5084167063 @default.
• W2596950809 creator A5084339717 @default.
• W2596950809 creator A5087205210 @default.
• W2596950809 date "2012-05-20" @default.
• W2596950809 modified "2023-09-27" @default.
• W2596950809 title "The effect of two BRM promoter variants on the risk of stage I/II upper aerodigestive tract cancers." @default.
• W2596950809 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.10522" @default.
• W2596950809 hasPublicationYear "2012" @default.
• W2596950809 type Work @default.
• W2596950809 sameAs 2596950809 @default.
• W2596950809 citedByCount "3" @default.
• W2596950809 countsByYear W25969508092015 @default.
• W2596950809 countsByYear W25969508092016 @default.
• W2596950809 countsByYear W25969508092017 @default.
• W2596950809 crossrefType "journal-article" @default.
• W2596950809 hasAuthorship W2596950809A5012748795 @default.
• W2596950809 hasAuthorship W2596950809A5017825677 @default.
• W2596950809 hasAuthorship W2596950809A5023531951 @default.
• W2596950809 hasAuthorship W2596950809A5027583508 @default.
• W2596950809 hasAuthorship W2596950809A5031847465 @default.
• W2596950809 hasAuthorship W2596950809A5034148230 @default.
• W2596950809 hasAuthorship W2596950809A5037245212 @default.
• W2596950809 hasAuthorship W2596950809A5043131704 @default.
• W2596950809 hasAuthorship W2596950809A5050035970 @default.
• W2596950809 hasAuthorship W2596950809A5055325118 @default.
• W2596950809 hasAuthorship W2596950809A5056959902 @default.
• W2596950809 hasAuthorship W2596950809A5066370108 @default.
• W2596950809 hasAuthorship W2596950809A5067008822 @default.
• W2596950809 hasAuthorship W2596950809A5068644454 @default.
• W2596950809 hasAuthorship W2596950809A5075347427 @default.
• W2596950809 hasAuthorship W2596950809A5075467430 @default.
• W2596950809 hasAuthorship W2596950809A5077514596 @default.
• W2596950809 hasAuthorship W2596950809A5084167063 @default.
• W2596950809 hasAuthorship W2596950809A5084339717 @default.
• W2596950809 hasAuthorship W2596950809A5087205210 @default.
• W2596950809 hasConcept C104317684 @default.
• W2596950809 hasConcept C121608353 @default.
• W2596950809 hasConcept C126322002 @default.
• W2596950809 hasConcept C143998085 @default.
• W2596950809 hasConcept C167227067 @default.
• W2596950809 hasConcept C179185449 @default.
• W2596950809 hasConcept C502942594 @default.
• W2596950809 hasConcept C54355233 @default.
• W2596950809 hasConcept C71924100 @default.
• W2596950809 hasConcept C83640560 @default.
• W2596950809 hasConcept C86803240 @default.
• W2596950809 hasConceptScore W2596950809C104317684 @default.
• W2596950809 hasConceptScore W2596950809C121608353 @default.
• W2596950809 hasConceptScore W2596950809C126322002 @default.
• W2596950809 hasConceptScore W2596950809C143998085 @default.
• W2596950809 hasConceptScore W2596950809C167227067 @default.
• W2596950809 hasConceptScore W2596950809C179185449 @default.
• W2596950809 hasConceptScore W2596950809C502942594 @default.
• W2596950809 hasConceptScore W2596950809C54355233 @default.
• W2596950809 hasConceptScore W2596950809C71924100 @default.
• W2596950809 hasConceptScore W2596950809C83640560 @default.
• W2596950809 hasConceptScore W2596950809C86803240 @default.
• W2596950809 hasLocation W25969508091 @default.
• W2596950809 hasOpenAccess W2596950809 @default.
• W2596950809 hasPrimaryLocation W25969508091 @default.
• W2596950809 hasRelatedWork W1211733072 @default.
• W2596950809 hasRelatedWork W1920450187 @default.
• W2596950809 hasRelatedWork W1987108325 @default.
• W2596950809 hasRelatedWork W1996240653 @default.
• W2596950809 hasRelatedWork W2013974230 @default.
• W2596950809 hasRelatedWork W2016116714 @default.
• W2596950809 hasRelatedWork W2019930406 @default.
• W2596950809 hasRelatedWork W2088985926 @default.
• W2596950809 hasRelatedWork W2125729230 @default.
• W2596950809 hasRelatedWork W2159547683 @default.
• W2596950809 hasRelatedWork W2263627581 @default.
• W2596950809 hasRelatedWork W2329404060 @default.
• W2596950809 hasRelatedWork W2397384107 @default.
• W2596950809 hasRelatedWork W2408361803 @default.
• W2596950809 hasRelatedWork W2498447980 @default.
• W2596950809 hasRelatedWork W2887592686 @default.
• W2596950809 hasRelatedWork W3016766734 @default.
• W2596950809 hasRelatedWork W3171594956 @default.
• W2596950809 hasRelatedWork W3197088910 @default.
• W2596950809 hasRelatedWork W605883157 @default.
• W2596950809 isParatext "false" @default.

• next