Matches in SemOpenAlex for { <https://semopenalex.org/work/W2596985281> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2596985281 endingPage "391" @default.
- W2596985281 startingPage "381" @default.
- W2596985281 abstract "The leukocyte Ig-like receptor B4 (LILRB4) is an inhibitory cell surface receptor, primarily expressed on mono-myeloid cells. It contains 2 C-type Ig-like extracellular domains and a long cytoplasmic domain that contains three intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Data suggest that LILRB4 suppresses Fc receptor-dependent monocyte functions via its ITIMs, but relative contributions of the three ITIMs are not characterised. To address this, tyrosine (Tyr) residues at positions 337, 389 and 419 were single, double or triple mutated to phenylalanine and stably transfected into a human monocytic cell line, THP-1. Intact Tyr 389 was sufficient to maximally inhibit FcγRI-mediated TNF-α production in THP-1 cells, but, paradoxically, Tyr 337 significantly enhanced TNF-α production. In contrast, bactericidal activity was significantly enhanced in mutants containing Tyr 419 , while Tyr 337 markedly inhibited bacteria killing. Taken together, these results indicate that LILRB4 might have dual inhibitory and activating functions, depending on the position of the functional tyrosine residues in its ITIMs and/or the nature of the stimuli." @default.
- W2596985281 created "2017-03-23" @default.
- W2596985281 creator A5012249897 @default.
- W2596985281 creator A5024247143 @default.
- W2596985281 creator A5067395273 @default.
- W2596985281 creator A5068474273 @default.
- W2596985281 creator A5079394170 @default.
- W2596985281 creator A5087723135 @default.
- W2596985281 date "2017-03-16" @default.
- W2596985281 modified "2023-10-12" @default.
- W2596985281 title "A dual positive and negative regulation of monocyte activation by leukocyte Ig-like receptor B4 depends on the position of the tyrosine residues in its ITIMs" @default.
- W2596985281 cites W1571964124 @default.
- W2596985281 cites W1775356736 @default.
- W2596985281 cites W1913862483 @default.
- W2596985281 cites W1966930760 @default.
- W2596985281 cites W1974670739 @default.
- W2596985281 cites W1985057592 @default.
- W2596985281 cites W1989702671 @default.
- W2596985281 cites W1997153240 @default.
- W2596985281 cites W2011444435 @default.
- W2596985281 cites W2028672566 @default.
- W2596985281 cites W2032770293 @default.
- W2596985281 cites W2040198458 @default.
- W2596985281 cites W2044670364 @default.
- W2596985281 cites W2045979079 @default.
- W2596985281 cites W2059688685 @default.
- W2596985281 cites W2065059034 @default.
- W2596985281 cites W2069358370 @default.
- W2596985281 cites W2070672259 @default.
- W2596985281 cites W2075175318 @default.
- W2596985281 cites W2076421143 @default.
- W2596985281 cites W2077112895 @default.
- W2596985281 cites W2082680509 @default.
- W2596985281 cites W2082721489 @default.
- W2596985281 cites W2086217063 @default.
- W2596985281 cites W2088569914 @default.
- W2596985281 cites W2097234404 @default.
- W2596985281 cites W2108282128 @default.
- W2596985281 cites W2130506153 @default.
- W2596985281 cites W2133613945 @default.
- W2596985281 cites W2137238554 @default.
- W2596985281 cites W2145094503 @default.
- W2596985281 cites W2151797745 @default.
- W2596985281 cites W2157118802 @default.
- W2596985281 cites W2157569416 @default.
- W2596985281 cites W4248990922 @default.
- W2596985281 doi "https://doi.org/10.1177/1753425917699465" @default.
- W2596985281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28409541" @default.
- W2596985281 hasPublicationYear "2017" @default.
- W2596985281 type Work @default.
- W2596985281 sameAs 2596985281 @default.
- W2596985281 citedByCount "13" @default.
- W2596985281 countsByYear W25969852812019 @default.
- W2596985281 countsByYear W25969852812020 @default.
- W2596985281 countsByYear W25969852812021 @default.
- W2596985281 countsByYear W25969852812022 @default.
- W2596985281 countsByYear W25969852812023 @default.
- W2596985281 crossrefType "journal-article" @default.
- W2596985281 hasAuthorship W2596985281A5012249897 @default.
- W2596985281 hasAuthorship W2596985281A5024247143 @default.
- W2596985281 hasAuthorship W2596985281A5067395273 @default.
- W2596985281 hasAuthorship W2596985281A5068474273 @default.
- W2596985281 hasAuthorship W2596985281A5079394170 @default.
- W2596985281 hasAuthorship W2596985281A5087723135 @default.
- W2596985281 hasBestOaLocation W25969852811 @default.
- W2596985281 hasConcept C153911025 @default.
- W2596985281 hasConcept C170493617 @default.
- W2596985281 hasConcept C2776165026 @default.
- W2596985281 hasConcept C55493867 @default.
- W2596985281 hasConcept C86803240 @default.
- W2596985281 hasConcept C95444343 @default.
- W2596985281 hasConceptScore W2596985281C153911025 @default.
- W2596985281 hasConceptScore W2596985281C170493617 @default.
- W2596985281 hasConceptScore W2596985281C2776165026 @default.
- W2596985281 hasConceptScore W2596985281C55493867 @default.
- W2596985281 hasConceptScore W2596985281C86803240 @default.
- W2596985281 hasConceptScore W2596985281C95444343 @default.
- W2596985281 hasIssue "4" @default.
- W2596985281 hasLocation W25969852811 @default.
- W2596985281 hasLocation W25969852812 @default.
- W2596985281 hasOpenAccess W2596985281 @default.
- W2596985281 hasPrimaryLocation W25969852811 @default.
- W2596985281 hasRelatedWork W1515173683 @default.
- W2596985281 hasRelatedWork W1878018588 @default.
- W2596985281 hasRelatedWork W1942554446 @default.
- W2596985281 hasRelatedWork W1965107562 @default.
- W2596985281 hasRelatedWork W1999543479 @default.
- W2596985281 hasRelatedWork W2012488971 @default.
- W2596985281 hasRelatedWork W2020061999 @default.
- W2596985281 hasRelatedWork W2039633449 @default.
- W2596985281 hasRelatedWork W2067532186 @default.
- W2596985281 hasRelatedWork W351849447 @default.
- W2596985281 hasVolume "23" @default.
- W2596985281 isParatext "false" @default.
- W2596985281 isRetracted "false" @default.
- W2596985281 magId "2596985281" @default.
- W2596985281 workType "article" @default.