FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597025862> ?p ?o ?g. }

• W2597025862 endingPage "383" @default.
• W2597025862 startingPage "374" @default.
• W2597025862 abstract "Co-administration of beta-lactam antibiotics and beta-lactamase inhibitors has been a favored treatment strategy against beta-lactamase-mediated bacterial antibiotic resistance, but the emergence of beta-lactamases resistant to current inhibitors necessitates the discovery of novel non-beta-lactam inhibitors. Peptides derived from the Ala46-Tyr51 region of the beta-lactamase inhibitor protein are considered as potent inhibitors of beta-lactamase; unfortunately, peptide delivery into the cell limits their potential. The properties of cell-penetrating peptides could guide the design of beta-lactamase inhibitory peptides. Here, our goal is to modify the peptide with the sequence RRGHYY that possesses beta-lactamase inhibitory activity under in vitro conditions. Inspired by the work on the cell-penetrating peptide pVEC, our approach involved the addition of the N-terminal hydrophobic residues, LLIIL, from pVEC to the inhibitor peptide to build a chimera. These residues have been reported to be critical in the uptake of pVEC. We tested the potential of RRGHYY and its chimeric derivative as a beta-lactamase inhibitory peptide on Escherichia coli cells and compared the results with the action of the antimicrobial peptide melittin, the beta-lactam antibiotic ampicillin, and the beta-lactamase inhibitor potassium clavulanate to get mechanistic details on their action. Our results show that the addition of LLIIL to the N-terminus of the beta-lactamase inhibitory peptide RRGHYY increases its membrane permeabilizing potential. Interestingly, the addition of this short stretch of hydrophobic residues also modified the inhibitory peptide such that it acquired antimicrobial property. We propose that addition of the hydrophobic LLIIL residues to the peptide N-terminus offers a promising strategy to design novel antimicrobial peptides in the battle against antibiotic resistance. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd." @default.
• W2597025862 created "2017-03-23" @default.
• W2597025862 creator A5002264469 @default.
• W2597025862 creator A5013237196 @default.
• W2597025862 creator A5025680089 @default.
• W2597025862 creator A5061247461 @default.
• W2597025862 date "2017-03-16" @default.
• W2597025862 modified "2023-09-26" @default.
• W2597025862 title "The effect of a beta-lactamase inhibitor peptide on bacterial membrane structure and integrity: a comparative study" @default.
• W2597025862 cites W1504486349 @default.
• W2597025862 cites W1508714775 @default.
• W2597025862 cites W1525948721 @default.
• W2597025862 cites W1535318109 @default.
• W2597025862 cites W1540438931 @default.
• W2597025862 cites W1571439495 @default.
• W2597025862 cites W1574601702 @default.
• W2597025862 cites W1584683177 @default.
• W2597025862 cites W1968821048 @default.
• W2597025862 cites W1970743383 @default.
• W2597025862 cites W1972528428 @default.
• W2597025862 cites W1978285695 @default.
• W2597025862 cites W1980460653 @default.
• W2597025862 cites W1980598017 @default.
• W2597025862 cites W1981312603 @default.
• W2597025862 cites W1989998611 @default.
• W2597025862 cites W1990733397 @default.
• W2597025862 cites W1995089537 @default.
• W2597025862 cites W1995116917 @default.
• W2597025862 cites W1995318118 @default.
• W2597025862 cites W1995762174 @default.
• W2597025862 cites W2000238072 @default.
• W2597025862 cites W2001642143 @default.
• W2597025862 cites W2009640317 @default.
• W2597025862 cites W2011532009 @default.
• W2597025862 cites W2015547235 @default.
• W2597025862 cites W2016877036 @default.
• W2597025862 cites W2021506214 @default.
• W2597025862 cites W2037305018 @default.
• W2597025862 cites W2042143995 @default.
• W2597025862 cites W2043108748 @default.
• W2597025862 cites W2044897724 @default.
• W2597025862 cites W2050748316 @default.
• W2597025862 cites W2054744155 @default.
• W2597025862 cites W2056013343 @default.
• W2597025862 cites W2056169996 @default.
• W2597025862 cites W2057870351 @default.
• W2597025862 cites W2068813747 @default.
• W2597025862 cites W2075252142 @default.
• W2597025862 cites W2077360598 @default.
• W2597025862 cites W2078169364 @default.
• W2597025862 cites W2078681344 @default.
• W2597025862 cites W2079798756 @default.
• W2597025862 cites W2088021352 @default.
• W2597025862 cites W2092000721 @default.
• W2597025862 cites W2102208951 @default.
• W2597025862 cites W2105668301 @default.
• W2597025862 cites W2107216251 @default.
• W2597025862 cites W2109241181 @default.
• W2597025862 cites W2111690190 @default.
• W2597025862 cites W2112689110 @default.
• W2597025862 cites W2114442012 @default.
• W2597025862 cites W2116959367 @default.
• W2597025862 cites W2127593402 @default.
• W2597025862 cites W2138860557 @default.
• W2597025862 cites W2139720036 @default.
• W2597025862 cites W2153594105 @default.
• W2597025862 cites W2161288893 @default.
• W2597025862 cites W2410090799 @default.
• W2597025862 cites W2536200613 @default.
• W2597025862 cites W4245676270 @default.
• W2597025862 cites W4247333866 @default.
• W2597025862 cites W4292320109 @default.
• W2597025862 doi "https://doi.org/10.1002/psc.2986" @default.
• W2597025862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28299853" @default.
• W2597025862 hasPublicationYear "2017" @default.
• W2597025862 type Work @default.
• W2597025862 sameAs 2597025862 @default.
• W2597025862 citedByCount "7" @default.
• W2597025862 countsByYear W25970258622018 @default.
• W2597025862 countsByYear W25970258622019 @default.
• W2597025862 countsByYear W25970258622021 @default.
• W2597025862 countsByYear W25970258622022 @default.
• W2597025862 crossrefType "journal-article" @default.
• W2597025862 hasAuthorship W2597025862A5002264469 @default.
• W2597025862 hasAuthorship W2597025862A5013237196 @default.
• W2597025862 hasAuthorship W2597025862A5025680089 @default.
• W2597025862 hasAuthorship W2597025862A5061247461 @default.
• W2597025862 hasConcept C104317684 @default.
• W2597025862 hasConcept C167625842 @default.
• W2597025862 hasConcept C185592680 @default.
• W2597025862 hasConcept C2778001312 @default.
• W2597025862 hasConcept C2779281246 @default.
• W2597025862 hasConcept C2910641391 @default.
• W2597025862 hasConcept C4937899 @default.
• W2597025862 hasConcept C501593827 @default.
• W2597025862 hasConcept C540938839 @default.
• W2597025862 hasConcept C547475151 @default.
• W2597025862 hasConcept C55493867 @default.

• next