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• W2597038088 abstract "5555 Background: Survivin plays a key role in apoptosis, proliferation and angiogenesis. It is overexpressed in 90% of epithelial OC making it an attractive target. Increases in expression have been correlated with progression and drug resistance. DPX-Survivac is a vaccine containing a mix of survivin HLA class I peptides designed to evoke a cytotoxic T cell response against survivin. This Phase I/Ib de-escalation study reports the safety and immune potency of DPX-Survivac in combination with metronomic low dose oral cyclophosphamide (CPA) in OC. Methods: 30 Stage IIc-IV advanced or recurrent OC patients (pts) with no evidence of disease progression post chemotherapy were enrolled. Dose limiting toxicities (DLT) were defined as ≥gd3 AEs, ≥gd2 allergic or autoimmune reactions by CTCAE v4.03. Immune correlates (MDSCs; T regs; B cells) and vaccine induced T cell immunity (ELISpot; tetramer analysis; multi-parametric intracellular cytokine staining) were assessed in purified PBMC and blood. Clinical response ..." @default.
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• W2597038088 date "2014-05-20" @default.
• W2597038088 modified "2023-09-26" @default.
• W2597038088 title "Phase I/Ib clinical and immunologic assessment of immunotherapeutic vaccine, DPX-Survivac in women with ovarian, Fallopian tube, or peritoneal cancer (OC)." @default.
• W2597038088 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.5555" @default.
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