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• W2597099053 abstract "The existence of males and females is a fundamental aspect of animal biology but the developmental mechanisms of sex determination and sexual differentiation exhibit surprising evolutionary diversity. Depending on the species, sex determination mechanisms range from genetic sex chromosome effects to environmental temperature effects and even to social cues that derive from local population structure. Many genes and molecules that play a role in sex determination biology have been identified, yet it has often remained unclear how these factors work together.In this thesis, developmental biology of sex determination is approached as a complex dynamic system. The scope is widened from animal biology to an examination of a general biological phenomenon, complexity of which is addressed directly. The method of investigation is a theoretical one relying mostly on heuristic problem solving methods and system identification procedures. Posing of novel questions enables formulation of alternative hypothesis about some fundamental aspects of sex determination biology. For instance, according to current view, two distinctly different developmental programs form ovaries and testes. Here, an integrating system description is provided where both testicular and ovarian development are derivatives of a common developmental scheme. Also, in this thesis sexual germ line development receives a much more prominent role than what is usually the case in sex determination studies. A premis is formed that the foundation of system properties of sex determination biology can be found in the developmental life cycle progression of the germ cell line. This enables formulation of testable prediction about the nature of the relationship between germ cell biology and developmental mechanisms of complex multicellularity.This work shows that a dynamical systems view can be applied to developmental biology and sex determination studies. Conceptual tools are provided for the attainment of a better understanding of genetic and molecular aspects of sex determination biology and sexually dimorphic development.; Sukupuolenmaaraytyminen, eli yksiloiden kehittyminen koiraiksi tai naaraiksi, on monitahoinen biologinen ilmio. Vaikka useat elainlajit selkeasti koostuvat koiras- ja naaraspuolisista yksiloista, voivat sukupuolta maaravat mekanismit olla hyvinkin erilaisia eri lajeilla. Esimerkkeina mainittakoot alkionkehityksen aikana vallitsevan lampotilan vaikutus (alligaattori), kromosomaaliset sukupuolierot (nisakkaat, linnut) ja jopa sosiaalisen populaatiorakenteen perusteella tapahtuva sukupuolenmaaraytyminen (eraat kalat).Vaikka biomolekulaarinen ja geneettinen tutkimus on paljastanut monia sukupuolenmaaraytymiseen osallistuvia tekijoita, useissa tapauksissa ei ole syntynyt selkeaa kokonaiskuvaa kyseisten tekijoiden valisista vuorovaikutuksista, tai niiden linkittymisesta varsinaisiin solu- ja kudostason kehitystapahtumiin. Tassa vaitoskirjassa sukupuolenmaaraytymisen kehitysbiologiaa lahestytaan kompleksien systeemien nakokulmasta. Tarkastelun…" @default.
• W2597099053 created "2017-03-23" @default.
• W2597099053 creator A5073280455 @default.
• W2597099053 date "2008-03-14" @default.
• W2597099053 modified "2023-09-25" @default.
• W2597099053 title "Developmental biology of sex determination : establishing a basis for systems approach" @default.
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