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• W2597102649 abstract "Metastatic lymph node ratio (MLNR) is a known significant predictor of disease-free survival in differentiated thyroid cancer. The authors investigated the ability of preoperative fluorine-18 fluorodeoxyglucose (F-FDG) PET/CT to predict recurrence after surgery with radioactive iodine therapy considering MLNR.A total of 274 patients who underwent preoperative PET/CT and surgery with radioactive iodine therapy were enrolled. The tumor-to-liver uptake ratio on PET/CT was calculated by dividing the maximum standardized uptake value of a primary lesion by the mean standardized uptake value of the normal liver. High F-FDG uptake was defined as tumor-to-liver uptake ratio more than the median cutoff value (2.1). MLNR was calculated by dividing the number of metastatic lymph nodes (LNs) by the number of cervical LNs removed. A high MLNR was also defined as one more than a threshold value (0.4), identified by plotting Kaplan-Meier survival curves and comparing them using the log-rank test. The prognostic significances of clinicopathologic variables were analyzed.Fifteen (5.5%) patients developed recurrence in the thyroid bed or in cervical LNs. Cox regression analysis showed that a high MLNR was significantly associated with a worse disease-free survival (odds ratio 6.95; 95% confidence interval: 2.36-20.47; P<0.001). A subgroup analysis of 70 patients with a high MLNR showed that only high F-FDG uptake was significantly associated with a worse disease-free survival (odds ratio 5.77; 95% confidence interval: 1.22-27.16; P=0.027).High F-FDG uptake of primary lesion on preoperative PET/CT has selective prognostic value according to the extent of metastatic LNs (MLNR>0.4)." @default.
• W2597102649 created "2017-03-23" @default.
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• W2597102649 date "2017-05-01" @default.
• W2597102649 modified "2023-09-28" @default.
• W2597102649 title "Prognostic value of preoperative 18F-FDG PET/CT in papillary thyroid cancer patients with a high metastatic lymph node ratio" @default.
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• W2597102649 doi "https://doi.org/10.1097/mnm.0000000000000657" @default.
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