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- W2597151714 abstract "Background: Tuberous sclerosis complex (TSC) is an inherited syndrome in which affected individuals are at increased risk for developing benign tumors. Mutation of the TSC-2 gene encoding tuberin on chromo- some 16p13.3 give rise to the clinical disorder of tuberous sclerosis characterized by the development of hamartomas. Objectives: In the present study, I conducted to examine whether overexpression of TSC-2 can affect the growth of human oral squamous cell carcinoma (OSCC) which have different expression level of p27K'P'. Methods: I constructed an expression vector containing sense-oriented rat TSC-2 cDNA with pcDNA3.1 (Invitrogen), and transfected to oral squamous cell carcinoma (B88) to regulate the expression of TSC-2 gene in each transfectant. Western blot analysis was carried out to determine the protein level of TSC-2. Therefore, Tumor volume and body weight of nude mice was examined using tumorigenicity assay. Results: Overexpression of TSC-2 exerted the growth inhibitory effect of oral squamous cell carcinoma. Sense-oriented B88-TSC-2 cancer cells, have high expression of p27K'P1. Moreover, tumor induced by TSC2 up-regulated transfectans become much smaller than those of control cells. Conclusion: overexpression of TSC-2 may exert the antitumor effect on oral squamous cell carcinoma through p27K'P' induction. Key word : TSC-2 - transfection - oral squamous cell carcinoma - pcDNA3.1 - mutation." @default.
- W2597151714 created "2017-03-23" @default.
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- W2597151714 date "2015-11-18" @default.
- W2597151714 modified "2023-09-26" @default.
- W2597151714 title "In vivo gene therapy with plasmid DNA-Tuberous sclerosis complex-2 (TSC-2) in an oral squamous cell carcinoma" @default.
- W2597151714 hasPublicationYear "2015" @default.
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