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- W2597173631 abstract "Mouse oocytes are predicted to contain more than 30 G-proteincoupled receptor (GPCR) mRNAs and of these a large number are orphan GPCRs with unknown function. GPR149 is an orphan G-protein coupled receptor previously reported to be expressed in chicken embryo dorsal root ganglion and gonads. By in silico subtraction and microarray analysis, we identified Gpr149 as an oocyte-enriched transcript in the mouse, and by sequence analysis, we found that it is evolutionarily conserved from amphibians to mammals. The importance of orphan GPCRs in oocyte physiology was recently highlighted by studies demonstrating premature resumption of meiosis in oocytes from Gpr3 null female mice. We hypothesize that GPR149 also plays important roles in oocyte growth and maturation. By multi-tissue RT-PCR analysis, we found that Gpr149 is highly expressed in the ovary, and also in the digestive tract and brain at low levels. Gpr149 levels are low in newborn ovaries but they increase throughout folliculogenesis. In the ovary, we found that granulosa cells did not express Gpr149, whereas germinal vesicle (GV) and meiosis II stage oocytes showed high levels of Gpr149 expression. After fertilization, Gpr149 expression declined, becoming undetectable by the two-cell stage. We are performing functional analysis studies to determine roles of GPR149 in oocyte physiology. This work is supported by National Institutes of Health (NIH) Grant HD42500 and NIH/National Institute of General Medical Sciences Medical Scientist Training Program Grant T32 GM07730. (poster)" @default.
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- W2597173631 date "2007-07-01" @default.
- W2597173631 modified "2023-09-25" @default.
- W2597173631 title "FUNCTIONAL STUDIES OF A NOVEL OOCYTE-SPECIFIC GENE, GPR149" @default.
- W2597173631 doi "https://doi.org/10.1093/biolreprod/77.s1.92a" @default.
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