Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597194746> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2597194746 abstract "Background: The study was designed to investigate theassociations among polymorphisms TNF-b NcoI and TNF-a -308G/A,plasma TNF-a levels and metabolic and anthropometric parametersrelated to insulin sensitivity in a set of 113 Caucasiansubjects undergoing oral glucose tolerance test (oGTT).Methods: Genotypes were detected by PCR; BMI, WHR, glycemiaduring oGTT, fasting immunoreactive insulin, fasting C-peptide,HbA1c, total cholesterol, triglycerides, HDL, LDL and plasmaTNF-a levels were measured in each subject. Results: Type 2diabetes was diagnosed in 10 subjects, impaired glucosetolerance (IGT) in 41, normal glucose tolerance (NGT) in 62.Significant differences among genotypes of the TNF-b NcoI wereobserved for FPG (P=0.0063), LDL (P=0.0179) and marginally fortotal cholesterol (P=0.0763) in NGT group. After theclassification of NGT subjects into obese and non-obeseaccording to BMI, associations of TNF-b NcoI with FPG, LDL andcholesterol were proved in non-obese subgroup only. TNF-a-308G/A polymorphism was not associated with any of theparameters studied. TNF-a levels did not revealed differenceamong NGT, IGT and DM groups or genotype-dependent differences.Conclusions: Our results indicate significant association ofthe TNF-b NcoI polymorphism with FPG, LDL and total cholesterolin normoglycemic non-obese Caucasian subjects. Thispolymorphism could be involved in genetic modulation of glucoseand lipid homeostasis and regulation of insulin sensitivityalready in healthy state. Disturbances of this regulation couldbe component of pathogenesis of type 2 diabetes mellitus." @default.
- W2597194746 created "2017-03-23" @default.
- W2597194746 creator A5027994902 @default.
- W2597194746 creator A5038317007 @default.
- W2597194746 creator A5038951792 @default.
- W2597194746 creator A5058394398 @default.
- W2597194746 creator A5076516552 @default.
- W2597194746 creator A5088183009 @default.
- W2597194746 date "2002-01-01" @default.
- W2597194746 modified "2023-10-04" @default.
- W2597194746 title "Polymorphism NcoI in tumor necrosis factor b is associated withfasting glycemia and lipid parameters in healthy non-obeseCaucasian subjects: Preliminary report" @default.
- W2597194746 hasPublicationYear "2002" @default.
- W2597194746 type Work @default.
- W2597194746 sameAs 2597194746 @default.
- W2597194746 citedByCount "0" @default.
- W2597194746 crossrefType "journal-article" @default.
- W2597194746 hasAuthorship W2597194746A5027994902 @default.
- W2597194746 hasAuthorship W2597194746A5038317007 @default.
- W2597194746 hasAuthorship W2597194746A5038951792 @default.
- W2597194746 hasAuthorship W2597194746A5058394398 @default.
- W2597194746 hasAuthorship W2597194746A5076516552 @default.
- W2597194746 hasAuthorship W2597194746A5088183009 @default.
- W2597194746 hasConcept C104317684 @default.
- W2597194746 hasConcept C126322002 @default.
- W2597194746 hasConcept C134018914 @default.
- W2597194746 hasConcept C135763542 @default.
- W2597194746 hasConcept C2777180221 @default.
- W2597194746 hasConcept C2777391703 @default.
- W2597194746 hasConcept C2778163477 @default.
- W2597194746 hasConcept C2779306644 @default.
- W2597194746 hasConcept C2780609358 @default.
- W2597194746 hasConcept C2780833929 @default.
- W2597194746 hasConcept C2780942790 @default.
- W2597194746 hasConcept C2910068830 @default.
- W2597194746 hasConcept C511355011 @default.
- W2597194746 hasConcept C54355233 @default.
- W2597194746 hasConcept C555293320 @default.
- W2597194746 hasConcept C71924100 @default.
- W2597194746 hasConcept C86803240 @default.
- W2597194746 hasConceptScore W2597194746C104317684 @default.
- W2597194746 hasConceptScore W2597194746C126322002 @default.
- W2597194746 hasConceptScore W2597194746C134018914 @default.
- W2597194746 hasConceptScore W2597194746C135763542 @default.
- W2597194746 hasConceptScore W2597194746C2777180221 @default.
- W2597194746 hasConceptScore W2597194746C2777391703 @default.
- W2597194746 hasConceptScore W2597194746C2778163477 @default.
- W2597194746 hasConceptScore W2597194746C2779306644 @default.
- W2597194746 hasConceptScore W2597194746C2780609358 @default.
- W2597194746 hasConceptScore W2597194746C2780833929 @default.
- W2597194746 hasConceptScore W2597194746C2780942790 @default.
- W2597194746 hasConceptScore W2597194746C2910068830 @default.
- W2597194746 hasConceptScore W2597194746C511355011 @default.
- W2597194746 hasConceptScore W2597194746C54355233 @default.
- W2597194746 hasConceptScore W2597194746C555293320 @default.
- W2597194746 hasConceptScore W2597194746C71924100 @default.
- W2597194746 hasConceptScore W2597194746C86803240 @default.
- W2597194746 hasIssue "3" @default.
- W2597194746 hasLocation W25971947461 @default.
- W2597194746 hasOpenAccess W2597194746 @default.
- W2597194746 hasPrimaryLocation W25971947461 @default.
- W2597194746 hasRelatedWork W1473131367 @default.
- W2597194746 hasRelatedWork W1991064195 @default.
- W2597194746 hasRelatedWork W2018183977 @default.
- W2597194746 hasRelatedWork W2059829758 @default.
- W2597194746 hasRelatedWork W2164297051 @default.
- W2597194746 hasRelatedWork W2164646777 @default.
- W2597194746 hasRelatedWork W2172164505 @default.
- W2597194746 hasRelatedWork W2312493650 @default.
- W2597194746 hasRelatedWork W2362706110 @default.
- W2597194746 hasRelatedWork W2364839536 @default.
- W2597194746 hasRelatedWork W2369647099 @default.
- W2597194746 hasRelatedWork W2392010420 @default.
- W2597194746 hasRelatedWork W2402455524 @default.
- W2597194746 hasRelatedWork W2438837356 @default.
- W2597194746 hasRelatedWork W2591640566 @default.
- W2597194746 hasRelatedWork W276690516 @default.
- W2597194746 hasRelatedWork W3032314285 @default.
- W2597194746 hasRelatedWork W3153347842 @default.
- W2597194746 hasRelatedWork W3202399953 @default.
- W2597194746 hasRelatedWork W2181693623 @default.
- W2597194746 hasVolume "28" @default.
- W2597194746 isParatext "false" @default.
- W2597194746 isRetracted "false" @default.
- W2597194746 magId "2597194746" @default.
- W2597194746 workType "article" @default.