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- W2597223890 abstract "Significance After breaks in animal epidermal barriers, repair genes are activated in the cells adjacent to wound sites that help regenerate the barrier. The fruit fly Drosophila melanogaster is a favorable genetic system to find molecular detection systems that sense wounds and activate repair genes. In this paper, we find that the Toll signaling pathway, including the extracellular ligand Spätzle, the Toll receptor, and the Dif transcription factor, form a detection system to sense broken epidermis and then activate regeneration genes. The Toll pathway thus is involved not only in the activation of genes involved in fighting microbial invasion after epidermal breaks, but also in the activation of genes that regenerate epidermal barrier function." @default.
- W2597223890 created "2017-03-23" @default.
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- W2597223890 date "2017-03-13" @default.
- W2597223890 modified "2023-09-24" @default.
- W2597223890 title "Toll pathway is required for wound-induced expression of barrier repair genes in the <i>Drosophila</i> epidermis" @default.
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- W2597223890 doi "https://doi.org/10.1073/pnas.1613917114" @default.
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