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- W2597234098 abstract "Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. Taken together, these results reveal a feedback loop between miRNAs and TFs. This feedback loop comprises miR-124, iASPP, STAT1, miR-155, TAp63 and ΔNp63, which are essential for CRC growth. Moreover, this feedback loop is perturbed in human colon carcinomas, which suggests that the manipulation of this microRNA-TF feedback loop has therapeutic potential for CRC." @default.
- W2597234098 created "2017-03-23" @default.
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- W2597234098 date "2017-03-16" @default.
- W2597234098 modified "2023-10-15" @default.
- W2597234098 title "The miR-124-p63 feedback loop modulates colorectal cancer growth" @default.
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- W2597234098 doi "https://doi.org/10.18632/oncotarget.16248" @default.
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