FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597245513> ?p ?o ?g. }

• W2597245513 abstract "The cell surface receptor CD6 regulates T cell activation in both activating and inhibitory manners. The adaptor protein SLP-76 is recruited to the phosphorylated CD6 cytoplasmic Y662 residue during T cell activation, providing an activating signal to T cells. In this study, a biochemical approach identified the SH2 domain-containing adaptor protein GADS as the dominant interaction partner for the CD6 cytoplasmic Y629 residue. Functional experiments in human Jurkat and primary T cells showed that both mutations Y629F and Y662F abolished costimulation by CD6. In addition, a restraint on T cell activation by CD6 was revealed in primary T cells expressing CD6 mutated at Y629 and Y662. These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6." @default.
• W2597245513 created "2017-03-23" @default.
• W2597245513 creator A5041117721 @default.
• W2597245513 creator A5043240263 @default.
• W2597245513 date "2017-06-01" @default.
• W2597245513 modified "2023-10-15" @default.
• W2597245513 title "T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex" @default.
• W2597245513 cites W1538486657 @default.
• W2597245513 cites W1649473267 @default.
• W2597245513 cites W1967564974 @default.
• W2597245513 cites W1982116555 @default.
• W2597245513 cites W1993039821 @default.
• W2597245513 cites W1994047471 @default.
• W2597245513 cites W1997988662 @default.
• W2597245513 cites W2025969443 @default.
• W2597245513 cites W2035469701 @default.
• W2597245513 cites W2037199116 @default.
• W2597245513 cites W2040098705 @default.
• W2597245513 cites W2057024012 @default.
• W2597245513 cites W2071262787 @default.
• W2597245513 cites W2071483073 @default.
• W2597245513 cites W2078739544 @default.
• W2597245513 cites W2079543912 @default.
• W2597245513 cites W2096868811 @default.
• W2597245513 cites W2098882468 @default.
• W2597245513 cites W2107815927 @default.
• W2597245513 cites W2116063068 @default.
• W2597245513 cites W2120096061 @default.
• W2597245513 cites W2121653179 @default.
• W2597245513 cites W2141826840 @default.
• W2597245513 cites W2143600483 @default.
• W2597245513 cites W2147971828 @default.
• W2597245513 cites W2154972504 @default.
• W2597245513 cites W2158034523 @default.
• W2597245513 cites W2170645681 @default.
• W2597245513 cites W2171419502 @default.
• W2597245513 cites W2191096966 @default.
• W2597245513 cites W2322044836 @default.
• W2597245513 cites W2412861620 @default.
• W2597245513 cites W2474651904 @default.
• W2597245513 cites W2559464872 @default.
• W2597245513 doi "https://doi.org/10.1128/mcb.00071-17" @default.
• W2597245513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5440646" @default.
• W2597245513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28289074" @default.
• W2597245513 hasPublicationYear "2017" @default.
• W2597245513 type Work @default.
• W2597245513 sameAs 2597245513 @default.
• W2597245513 citedByCount "22" @default.
• W2597245513 countsByYear W25972455132017 @default.
• W2597245513 countsByYear W25972455132018 @default.
• W2597245513 countsByYear W25972455132019 @default.
• W2597245513 countsByYear W25972455132020 @default.
• W2597245513 countsByYear W25972455132021 @default.
• W2597245513 countsByYear W25972455132022 @default.
• W2597245513 countsByYear W25972455132023 @default.
• W2597245513 crossrefType "journal-article" @default.
• W2597245513 hasAuthorship W2597245513A5041117721 @default.
• W2597245513 hasAuthorship W2597245513A5043240263 @default.
• W2597245513 hasBestOaLocation W25972455131 @default.
• W2597245513 hasConcept C11960822 @default.
• W2597245513 hasConcept C1491633281 @default.
• W2597245513 hasConcept C153911025 @default.
• W2597245513 hasConcept C170493617 @default.
• W2597245513 hasConcept C178790620 @default.
• W2597245513 hasConcept C179464577 @default.
• W2597245513 hasConcept C183786373 @default.
• W2597245513 hasConcept C185592680 @default.
• W2597245513 hasConcept C190062978 @default.
• W2597245513 hasConcept C19317047 @default.
• W2597245513 hasConcept C2776090121 @default.
• W2597245513 hasConcept C2776620830 @default.
• W2597245513 hasConcept C54355233 @default.
• W2597245513 hasConcept C544153396 @default.
• W2597245513 hasConcept C55493867 @default.
• W2597245513 hasConcept C86803240 @default.
• W2597245513 hasConcept C8891405 @default.
• W2597245513 hasConcept C95444343 @default.
• W2597245513 hasConceptScore W2597245513C11960822 @default.
• W2597245513 hasConceptScore W2597245513C1491633281 @default.
• W2597245513 hasConceptScore W2597245513C153911025 @default.
• W2597245513 hasConceptScore W2597245513C170493617 @default.
• W2597245513 hasConceptScore W2597245513C178790620 @default.
• W2597245513 hasConceptScore W2597245513C179464577 @default.
• W2597245513 hasConceptScore W2597245513C183786373 @default.
• W2597245513 hasConceptScore W2597245513C185592680 @default.
• W2597245513 hasConceptScore W2597245513C190062978 @default.
• W2597245513 hasConceptScore W2597245513C19317047 @default.
• W2597245513 hasConceptScore W2597245513C2776090121 @default.
• W2597245513 hasConceptScore W2597245513C2776620830 @default.
• W2597245513 hasConceptScore W2597245513C54355233 @default.
• W2597245513 hasConceptScore W2597245513C544153396 @default.
• W2597245513 hasConceptScore W2597245513C55493867 @default.
• W2597245513 hasConceptScore W2597245513C86803240 @default.
• W2597245513 hasConceptScore W2597245513C8891405 @default.
• W2597245513 hasConceptScore W2597245513C95444343 @default.
• W2597245513 hasIssue "11" @default.
• W2597245513 hasLocation W25972455131 @default.
• W2597245513 hasLocation W25972455132 @default.
• W2597245513 hasLocation W25972455133 @default.
• W2597245513 hasLocation W25972455134 @default.

• next