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- W2597286978 abstract "Significance Symptoms of benign prostatic hyperplasia (BPH) affect many older men, but the etiology of the disease is largely unknown. We show that male mice develop prostatic stromal hyperplasia accompanied by lower urinary tract symptoms that appear similar to BPH with conditional homozygous deletion of the tumor suppressor gene, Stk11 (serine threonine kinase 11), in the Müllerian duct mesenchyme (MDM), which regresses in males during early fetal development. Cell lineage tracing studies confirmed that cells from the caudal MDM contribute to the stromal cell population of the dorsal periurethral area, which has been compared with the transition zone of the human prostate. These studies show that some of the stromal cells of the prostate are MD-derived, and that their mutation can lead to BPH." @default.
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- W2597286978 date "2017-03-13" @default.
- W2597286978 modified "2023-10-18" @default.
- W2597286978 title "Specific deletion of LKB1/ <i>Stk11</i> in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice" @default.
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- W2597286978 doi "https://doi.org/10.1073/pnas.1612284114" @default.
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