FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2597327528> ?p ?o ?g. }

• W2597327528 endingPage "348" @default.
• W2597327528 startingPage "341" @default.
• W2597327528 abstract "The protein <i>β</i>-arrestin (<i>β</i>arr) 2 directly interacts with receptors and signaling pathways that mediate the behavioral effects of drugs of abuse, making it a prime candidate for therapeutic interventions. <i>β</i>arr2 drives desensitization and internalization of G protein–coupled receptors, including dopamine, opioid, and cannabinoid receptors, and it can also trigger G protein–independent intracellular signaling. <i>β</i>arr2 mediates several drug-induced behaviors, but the relationship is complex and dependent on the type of behavior (e.g., psychomotor versus reward), the class of drug (e.g., psychostimulant versus opioid), and the circuit being interrogated (e.g., brain region, cell type, and specific receptor ligand). Here we discuss the current state of research concerning the contribution of <i>β</i>arr2 to the psychomotor and rewarding effects of addictive drugs. Next we identify key knowledge gaps and suggest new tools and approaches needed to further elucidate the neuroanatomical substrates and neurobiological mechanisms to explain how <i>β</i>arr2 modulates behavioral responses to drugs of abuse, as well as its potential as a therapeutic target." @default.
• W2597327528 created "2017-03-23" @default.
• W2597327528 creator A5026164142 @default.
• W2597327528 creator A5090310054 @default.
• W2597327528 date "2017-03-16" @default.
• W2597327528 modified "2023-10-18" @default.
• W2597327528 title "Arresting the Development of Addiction: The Role of<i>β</i>-Arrestin 2 in Drug Abuse" @default.
• W2597327528 cites W1488100833 @default.
• W2597327528 cites W1534600986 @default.
• W2597327528 cites W1709672860 @default.
• W2597327528 cites W1909076506 @default.
• W2597327528 cites W1959936171 @default.
• W2597327528 cites W1967760715 @default.
• W2597327528 cites W1974968093 @default.
• W2597327528 cites W1975106280 @default.
• W2597327528 cites W1981952236 @default.
• W2597327528 cites W1987067051 @default.
• W2597327528 cites W1993717649 @default.
• W2597327528 cites W1994495174 @default.
• W2597327528 cites W1996214244 @default.
• W2597327528 cites W1998674360 @default.
• W2597327528 cites W2003596618 @default.
• W2597327528 cites W2003661073 @default.
• W2597327528 cites W2004120139 @default.
• W2597327528 cites W2008748109 @default.
• W2597327528 cites W2008935385 @default.
• W2597327528 cites W2015087988 @default.
• W2597327528 cites W2022633426 @default.
• W2597327528 cites W2023453933 @default.
• W2597327528 cites W2023637370 @default.
• W2597327528 cites W2023812185 @default.
• W2597327528 cites W2030205627 @default.
• W2597327528 cites W2030222651 @default.
• W2597327528 cites W2031363100 @default.
• W2597327528 cites W2036251618 @default.
• W2597327528 cites W2049253479 @default.
• W2597327528 cites W2051639699 @default.
• W2597327528 cites W2054421618 @default.
• W2597327528 cites W2056772835 @default.
• W2597327528 cites W2059628641 @default.
• W2597327528 cites W2064318896 @default.
• W2597327528 cites W2076100881 @default.
• W2597327528 cites W2079978216 @default.
• W2597327528 cites W2082956345 @default.
• W2597327528 cites W2085819418 @default.
• W2597327528 cites W2088134302 @default.
• W2597327528 cites W2089050079 @default.
• W2597327528 cites W2089056164 @default.
• W2597327528 cites W2091366475 @default.
• W2597327528 cites W2092099338 @default.
• W2597327528 cites W2097744565 @default.
• W2597327528 cites W2097994890 @default.
• W2597327528 cites W2103781325 @default.
• W2597327528 cites W2103882569 @default.
• W2597327528 cites W2108856429 @default.
• W2597327528 cites W2109083102 @default.
• W2597327528 cites W2110045591 @default.
• W2597327528 cites W2111578660 @default.
• W2597327528 cites W2117785206 @default.
• W2597327528 cites W2120387289 @default.
• W2597327528 cites W2124836310 @default.
• W2597327528 cites W2125708849 @default.
• W2597327528 cites W2127424619 @default.
• W2597327528 cites W2127480214 @default.
• W2597327528 cites W2130536801 @default.
• W2597327528 cites W2133402952 @default.
• W2597327528 cites W2134939120 @default.
• W2597327528 cites W2140864873 @default.
• W2597327528 cites W2151526347 @default.
• W2597327528 cites W2156480657 @default.
• W2597327528 cites W2156753857 @default.
• W2597327528 cites W2164915356 @default.
• W2597327528 cites W2165398609 @default.
• W2597327528 cites W2176163595 @default.
• W2597327528 cites W2275148408 @default.
• W2597327528 cites W2300047490 @default.
• W2597327528 cites W2303462194 @default.
• W2597327528 cites W2306894756 @default.
• W2597327528 cites W2341523955 @default.
• W2597327528 cites W2399759053 @default.
• W2597327528 cites W2413686208 @default.
• W2597327528 cites W2467643547 @default.
• W2597327528 cites W2491076684 @default.
• W2597327528 cites W2512819857 @default.
• W2597327528 cites W2532143627 @default.
• W2597327528 cites W2550530158 @default.
• W2597327528 cites W2559256288 @default.
• W2597327528 cites W2581696375 @default.
• W2597327528 cites W2581751720 @default.
• W2597327528 cites W4291166395 @default.
• W2597327528 cites W4296309414 @default.
• W2597327528 cites W580628991 @default.
• W2597327528 cites W78722479 @default.
• W2597327528 doi "https://doi.org/10.1124/jpet.117.240622" @default.
• W2597327528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5443318" @default.
• W2597327528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28302862" @default.
• W2597327528 hasPublicationYear "2017" @default.
• W2597327528 type Work @default.

• next